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Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase beta

Summary

UniProt ID: Q8I6Z7
Gene Symbol: PDEbeta PDE2 PF3D7_1321500.1
Gene ID: 813666
Organism: Plasmodium falciparum 3D7

External Links

Re-Glyco: Q8I6Z7

Annotation

Keyword: Cell membrane Endoplasmic reticulum Glycoprotein Hydrolase Metal-binding Reference proteome Transmembrane helix cAMP cGMP

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	Reference
cAMP catabolic process	IEA	GO_REF
signal transduction	ISS	PMID
signal transduction	IEA	GO_REF
obsolete negative regulation of cAMP-mediated signaling
cGMP catabolic process	IDA	PMID

GO Hierarchy

biological process

cellular process [inference]

signal transduction

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

cGMP metabolic process [inference]

cGMP catabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

cGMP metabolic process [inference]

cGMP catabolic process

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cyclic nucleotide catabolic process [inference]

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cyclic nucleotide metabolic process [inference]

cyclic nucleotide catabolic process [inference]

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

cGMP metabolic process [inference]

cGMP catabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

cGMP metabolic process [inference]

cGMP catabolic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cyclic nucleotide catabolic process [inference]

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

cGMP metabolic process [inference]

cGMP catabolic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

cGMP metabolic process [inference]

cGMP catabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

cGMP metabolic process [inference]

cGMP catabolic process

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cyclic nucleotide catabolic process [inference]

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cyclic nucleotide metabolic process [inference]

cyclic nucleotide catabolic process [inference]

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

cGMP metabolic process [inference]

cGMP catabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

cGMP metabolic process [inference]

cGMP catabolic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cyclic nucleotide catabolic process [inference]

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

cGMP metabolic process [inference]

cGMP catabolic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cyclic nucleotide catabolic process [inference]

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cyclic nucleotide catabolic process [inference]

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cyclic nucleotide catabolic process [inference]

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

purine-containing compound catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

carbohydrate derivative catabolic process [inference]

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cyclic nucleotide catabolic process [inference]

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

cGMP metabolic process [inference]

cGMP catabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

cGMP metabolic process [inference]

cGMP catabolic process

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cyclic nucleotide catabolic process [inference]

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cyclic nucleotide metabolic process [inference]

cyclic nucleotide catabolic process [inference]

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

cGMP metabolic process [inference]

cGMP catabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

cGMP metabolic process [inference]

cGMP catabolic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cyclic nucleotide catabolic process [inference]

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

cGMP metabolic process [inference]

cGMP catabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

cGMP metabolic process [inference]

cGMP catabolic process

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cyclic nucleotide catabolic process [inference]

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cyclic nucleotide metabolic process [inference]

cyclic nucleotide catabolic process [inference]

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

cGMP metabolic process [inference]

cGMP catabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

cGMP metabolic process [inference]

cGMP catabolic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cyclic nucleotide catabolic process [inference]

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

cGMP metabolic process [inference]

cGMP catabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

cGMP metabolic process [inference]

cGMP catabolic process

purine-containing compound catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

carbohydrate derivative metabolic process [inference]

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

cGMP metabolic process [inference]

cGMP catabolic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

carbohydrate derivative catabolic process [inference]

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

regulation of intracellular signal transduction [inference]

regulation of cAMP/PKA signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

regulation of intracellular signal transduction [inference]

regulation of cAMP/PKA signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

regulation of intracellular signal transduction [inference]

regulation of cAMP/PKA signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

Displaying **all 4** entries
GO Term	Evidence Code	Reference
endoplasmic reticulum membrane	IDA	PMID
endoplasmic reticulum membrane	IEA	GO_REF
plasma membrane	IDA	PMID
plasma membrane	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	Reference
3',5'-cyclic-AMP phosphodiesterase activity	IDA	PMID
3',5'-cyclic-AMP phosphodiesterase activity	IBA	GO_REF
3',5'-cyclic-AMP phosphodiesterase activity	IEA	GO_REF
calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity	ISS	PMID
metal ion binding

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

cyclic-nucleotide phosphodiesterase activity [inference]

3',5'-cyclic-nucleotide phosphodiesterase activity [inference]

3',5'-cyclic-AMP phosphodiesterase activity

calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity

3',5'-cyclic-GMP phosphodiesterase activity

calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGKVEDFEEHNKNSNQDIEKNVGNRRRSNSNTINDQNENINKNKAIVTKKSFIMNLLRNKEKTKVEQNDDNIVENMNERKNSLKDMSLISDNVEKDNKVKKKNSYLKNLNILGKTKSIEFSFPSNILNNARKNIQEIDEESPLTSNSLRTYKEGISEDNRQNQRNADNNSLNWSTSNINTECNSEFSNIEVKVLKTEKSNSVKLKDNIIDIPNDKNKKELQEINIKNTNKDSYKNLYLKVRNSISFNDNIKIDDENKNDKNNIIDNYNNYDDINSSNEITIDGLNHDDNIKKIDNINNFDNKHDDNLQDHHQNHVHHTFRSSRKSLGNIKSNNTNIKLNNDKNFDTNINKRSILEKYFYDIWKRNITIKKEIYSLSSKNPPNPLKSTFADACQNESSEKELLKKIPLKFNDDSIESLYVLNLNNWISSRMIIIGIVMLILSFIIWPLTTWSLKTSTWGRETYIIILFHTLMAINTLILIFFIIIGSTELCKYSECMSYVLFSLMVALWGLWNIAIGLTLEYNPNLSEMPTTTYELEMIYVLTYIYGFLPLVIIDIFFPSRTKYNWIIHLIFIFLNSSSIILVGSAKPDFVPEIYVVFRILAYTTLCIFLYIGSYTSELQIRYVFYNLLVAGYKLDKIESDMKNKTSNKKISTGIEDLINMLKECTKVILELENETDTNFNVHTKTSYCSNILEQCLSTLTKSDNLYNIDYNVLENPENKKFIEAYVSKSKSNFAGEEVPKGVDFKLNKSFSNNDCISTDKVDLDKKQIKKFLKQINISQLTKMIQFIDNKLLSDWDFNCLTYFDESEYPFFDINLSLICTIDHNIPINIIINFLCFVEKQYNNVPYHNTIHATMVTQKFFCLAKKLGIYDDLEYKIKLVMFISGICHDIGHPGYNNLFFVNSLHPLSIIYNDISVLENYHASITFKILQLNQCNILKNFSEKDFRMMRSYIIELILSTDMKHHFEIISKFRIRRENEDFDYIKNSDDLLILTKMIIKSADISHGSVSWSEHYCWCQRVLSEFYTQGDEELKNKMPLSPLCDRTKHNEVCKSQITFLKFVVMPLFEELSHIDNNKFIKSFCLKRLNSNCIMWDTLMKEEKTIEVYDPAAVKLKDKKKKKVDKKKKSYIDLTLFFIKNVSD

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
524	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
G alpha (s) signalling events	Plasmodium falciparum
PDE3B signalling	Plasmodium falciparum
Smooth Muscle Contraction	Plasmodium falciparum
cGMP effects	Plasmodium falciparum

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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