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Mitochondrial inner membrane m-AAA protease component AFG3L2

Summary

UniProt ID: Q8JZQ2
Gene Symbol: Afg3l2
Gene ID: 69597
Organism: Mus musculus (house mouse)

External Links

GlyGen: Q8JZQ2
PubChem: Q8JZQ2
O-GlcNAcAtlas: Q8JZQ2
Re-Glyco: Q8JZQ2

Annotation

Keyword: ATP-binding Direct protein sequencing Disease variant Metal-binding Metalloprotease Mitochondrion inner membrane Reference proteome Transit peptide Transmembrane helix Zinc

Gene Ontology (GO)

Displaying entries **1 - 5** of 48 in total

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GO Term	Evidence Code	Reference
proteolysis	ISO	GO_REF
proteolysis	IEA	GO_REF GO_REF
mitochondrion organization	IGI	PMID
axonogenesis	ISS	GO_REF
axonogenesis	ISO	GO_REF

GO Hierarchy

biological process

cellular process [inference]

ensheathment of neurons [inference]

axon ensheathment [inference]

myelination

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein quality control for misfolded or incompletely synthesized proteins [inference]

mitochondrial protein quality control

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein quality control for misfolded or incompletely synthesized proteins [inference]

mitochondrial protein quality control

protein metabolic process [inference]

proteolysis

protein processing

membrane protein proteolysis

protein catabolic process

protein quality control for misfolded or incompletely synthesized proteins [inference]

mitochondrial protein quality control

protein maturation

protein processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

membrane protein proteolysis

protein catabolic process

protein quality control for misfolded or incompletely synthesized proteins [inference]

mitochondrial protein quality control

protein maturation

protein processing

intercellular transport [inference]

cellular developmental process [inference]

cell development [inference]

muscle cell development

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to glutathione

cellular response to oxygen-containing compound [inference]

cellular response to glutathione

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

oligopeptide transmembrane transport [inference]

tripeptide transmembrane transport [inference]

glutathione transmembrane transport [inference]

glutathione import into mitochondrion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

mitochondrial membrane organization [inference]

inner mitochondrial membrane organization [inference]

cristae formation

mitochondrial fusion

organelle fusion [inference]

mitochondrial fusion

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

cell junction organization [inference]

synapse organization [inference]

neuromuscular junction development

membrane organization [inference]

mitochondrial membrane organization [inference]

inner mitochondrial membrane organization [inference]

cristae formation

developmental process [inference]

anatomical structure morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

anatomical structure development [inference]

cell development [inference]

muscle cell development

animal gross anatomical part developmental process [inference]

nerve development

cellular developmental process [inference]

cell development [inference]

muscle cell development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

mitochondrial calcium ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

mitochondrial calcium ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

mitochondrial calcium ion homeostasis

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

mitochondrial calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

mitochondrial calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

mitochondrial calcium ion homeostasis

response to stimulus [inference]

response to external stimulus [inference]

reflex [inference]

righting reflex

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to glutathione

cellular response to oxygen-containing compound [inference]

cellular response to glutathione

response to nitrogen compound [inference]

response to glutathione [inference]

cellular response to glutathione

cellular response to nitrogen compound [inference]

cellular response to glutathione

response to oxygen-containing compound [inference]

response to glutathione [inference]

cellular response to glutathione

cellular response to oxygen-containing compound [inference]

cellular response to glutathione

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to glutathione

cellular response to oxygen-containing compound [inference]

cellular response to glutathione

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

intercellular transport [inference]

peptide transport [inference]

oligopeptide transport [inference]

oligopeptide transmembrane transport [inference]

tripeptide transmembrane transport [inference]

glutathione transmembrane transport [inference]

glutathione import into mitochondrion

tripeptide transport [inference]

glutathione transport [inference]

glutathione transmembrane transport [inference]

glutathione import into mitochondrion

tripeptide transmembrane transport [inference]

glutathione transmembrane transport [inference]

glutathione import into mitochondrion

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

oligopeptide transmembrane transport [inference]

tripeptide transmembrane transport [inference]

glutathione transmembrane transport [inference]

glutathione import into mitochondrion

nitrogen compound transport [inference]

oligopeptide transport [inference]

oligopeptide transmembrane transport [inference]

tripeptide transmembrane transport [inference]

glutathione transmembrane transport [inference]

glutathione import into mitochondrion

tripeptide transport [inference]

glutathione transport [inference]

glutathione transmembrane transport [inference]

glutathione import into mitochondrion

tripeptide transmembrane transport [inference]

glutathione transmembrane transport [inference]

glutathione import into mitochondrion

modified amino acid transport [inference]

glutathione transport [inference]

glutathione transmembrane transport [inference]

glutathione import into mitochondrion

sulfur compound transport [inference]

glutathione transport [inference]

glutathione transmembrane transport [inference]

glutathione import into mitochondrion

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of calcium import into the mitochondrion

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of calcium import into the mitochondrion

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of calcium import into the mitochondrion

regulation of growth [inference]

regulation of developmental growth [inference]

regulation of multicellular organism growth

regulation of developmental process [inference]

regulation of developmental growth [inference]

regulation of multicellular organism growth

regulation of cellular process [inference]

regulation of transmembrane transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of calcium import into the mitochondrion

regulation of multicellular organismal process [inference]

regulation of multicellular organism growth

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GO Term	Evidence Code	Reference
mitochondrion	ISO	GO_REF
mitochondrion	IEA	GO_REF
mitochondrion	HDA	PMID
mitochondrial inner membrane	ISO	GO_REF
mitochondrial inner membrane	EXP	PMID

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

inner mitochondrial membrane protein complex [inference]

m-AAA complex

mitochondrial protein-containing complex [inference]

inner mitochondrial membrane protein complex [inference]

m-AAA complex

catalytic complex [inference]

peptidase complex [inference]

m-AAA complex

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	Reference
ATP-dependent peptidase activity	IEA	GO_REF
metalloendopeptidase activity	ISS	GO_REF
metalloendopeptidase activity	ISO	GO_REF
metalloendopeptidase activity	IBA	GO_REF
metalloendopeptidase activity	IEA	GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

ATP-dependent peptidase activity

metallopeptidase activity

metalloendopeptidase activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

ATP-dependent peptidase activity

metallopeptidase activity

metalloendopeptidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular carrier activity [inference]

protein carrier activity [inference]

membrane protein dislocase activity

ATP-dependent activity [inference]

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MAHRCLLLWSRGGCRRGLPPLLVPRGCLGPDRRPCLRTLYQYATVQTASSRRSLLRDVIAAYQRFCSRPPKGFEKYFPNGKNGKKASEPKEAVGEKKEPQPSGPQPSGGAGGGGGKRRGKKEDSHWWSRFQKGDFPWDDKDFRMYFLWTALFWGGVMIYFVFKSSGREITWKDFVNNYLSKGVVDRLEVVNKRFVRVTFTPGKTPVDGQYVWFNIGSVDTFERNLETLQQELGIEGENRVPVVYIAESDGSFLLSMLPTVLIIAFLLYTIRRGPAGIGRTGRGMGGLFSVGETTAKVLKDEIDVKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKRGRGNFGGQSEQENTLNQLLVEMDGFNTTTNVVILAGTNRPDILDPALLRPGRFDRQIFIGPPDIKGRASIFKVHLRPLKLDSALEKDKLARKLASLTPGFSGADVANVCNEAALIAARHLSDAINEKHFEQAIERVIGGLEKKTQVLQPEEKKTVAYHEAGHAVAGWYLEHADPLLKVSIIPRGKGLGYAQYLPKEQYLYTKEQLLDRMCMTLGGRVSEEIFFGRITTGAQDDLRKVTQSAYAQIVQFGMNEKVGQISFDLPRQGDMVLEKPYSEATARMIDDEVRILISDAYRRTVALLTEKKADVEKVALLLLEKEVLDKNDMVQLLGPRPFTEKSTYEEFVEGTGSLDEDTSLPEGLQDWNKEREKEEKKEKEKEEPLNEKVVS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
346			G49108TO	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Mitochondrial protein degradation	Mus musculus
Processing of SMDT1	Mus musculus

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050977	spinocerebellar ataxia 28	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

International Collaboration

Acknowledgements