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Sodium-coupled neutral amino acid symporter 1

Summary

UniProt ID: Q8K2P7
Gene Symbol: Nat2 Slc38a1 Snat1
Gene ID: 105727
Organism: Mus musculus (house mouse)

External Links

GlyGen: Q8K2P7
PubChem: Q8K2P7
Re-Glyco: Q8K2P7

Annotation

Keyword: Alternative splicing Amino-acid transport Cell membrane Disulfide bond Glycoprotein Phosphoprotein Reference proteome Sodium transport Symport Transmembrane helix

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
amino acid transmembrane transport	IBA	GO_REF
L-glutamine transport	IDA	PMID PMID
L-glutamine transport	IBA	GO_REF
female pregnancy	IEA	GO_REF
GABA biosynthetic process

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

amino acid biosynthetic process [inference]

GABA biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

non-proteinogenic amino acid biosynthetic process [inference]

GABA biosynthetic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

GABA biosynthetic process

non-proteinogenic amino acid metabolic process [inference]

GABA metabolic process [inference]

GABA biosynthetic process

non-proteinogenic amino acid biosynthetic process [inference]

GABA biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

non-proteinogenic amino acid biosynthetic process [inference]

GABA biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

GABA metabolic process [inference]

GABA biosynthetic process

carboxylic acid biosynthetic process [inference]

non-proteinogenic amino acid biosynthetic process [inference]

GABA biosynthetic process

non-proteinogenic amino acid metabolic process [inference]

GABA metabolic process [inference]

GABA biosynthetic process

non-proteinogenic amino acid biosynthetic process [inference]

GABA biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

non-proteinogenic amino acid biosynthetic process [inference]

GABA biosynthetic process

transmembrane transport [inference]

amino acid transmembrane transport

amino acid import across plasma membrane [inference]

L-glutamine import across plasma membrane

L-alpha-amino acid transmembrane transport

L-glutamine import across plasma membrane

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

L-glutamine import across plasma membrane

carboxylic acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport

L-glutamine import across plasma membrane

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

multi-multicellular organism process [inference]

female pregnancy

localization [inference]

establishment of localization [inference]

transport [inference]

amino acid transport [inference]

amino acid transmembrane transport

amino acid import across plasma membrane [inference]

L-glutamine import across plasma membrane

L-alpha-amino acid transmembrane transport

L-glutamine import across plasma membrane

neutral amino acid transport

L-glutamine transport

L-glutamine import across plasma membrane

L-amino acid transport [inference]

L-glutamine transport

L-glutamine import across plasma membrane

L-alpha-amino acid transmembrane transport

L-glutamine import across plasma membrane

amino acid import

organic cation transport [inference]

L-glutamine transport

L-glutamine import across plasma membrane

organic anion transport [inference]

carboxylic acid transport [inference]

L-amino acid transport [inference]

L-glutamine transport

L-glutamine import across plasma membrane

L-alpha-amino acid transmembrane transport

L-glutamine import across plasma membrane

carboxylic acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport

L-glutamine import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

L-amino acid transport [inference]

L-glutamine transport

L-glutamine import across plasma membrane

L-alpha-amino acid transmembrane transport

L-glutamine import across plasma membrane

carboxylic acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport

L-glutamine import across plasma membrane

transmembrane transport [inference]

amino acid transmembrane transport

amino acid import across plasma membrane [inference]

L-glutamine import across plasma membrane

L-alpha-amino acid transmembrane transport

L-glutamine import across plasma membrane

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

L-glutamine import across plasma membrane

carboxylic acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport

L-glutamine import across plasma membrane

nitrogen compound transport [inference]

L-amino acid transport [inference]

L-glutamine transport

L-glutamine import across plasma membrane

L-alpha-amino acid transmembrane transport

L-glutamine import across plasma membrane

import into cell [inference]

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

L-glutamine import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of biological quality [inference]

regulation of synaptic plasticity

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
plasma membrane	ISO	GO_REF GO_REF
plasma membrane	EXP	PMID
plasma membrane	IDA	PMID
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

plasma membrane region [inference]

basolateral plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

cell body [inference]

neuronal cell body

side of membrane [inference]

external side of plasma membrane [inference]

external side of apical plasma membrane

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	Reference
amino acid:sodium symporter activity	ISS	GO_REF
amino acid:sodium symporter activity	ISO	GO_REF
amino acid:sodium symporter activity	IEA	GO_REF
neutral L-amino acid:sodium symporter activity	ISS	GO_REF
neutral L-amino acid:sodium symporter activity	ISO	GO_REF

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity

neutral L-amino acid:sodium symporter activity

glycine:sodium symporter activity

solute:sodium symporter activity [inference]

amino acid:sodium symporter activity

neutral L-amino acid:sodium symporter activity

glycine:sodium symporter activity

organic acid:sodium symporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

amino acid:sodium symporter activity

neutral L-amino acid:sodium symporter activity

glycine:sodium symporter activity

organic acid:sodium symporter activity [inference]

amino acid transmembrane transporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity

neutral L-amino acid:sodium symporter activity

glycine:sodium symporter activity

neutral L-amino acid transmembrane transporter activity [inference]

neutral L-amino acid:sodium symporter activity

glycine:sodium symporter activity

L-glutamine transmembrane transporter activity

glycine transmembrane transporter activity [inference]

glycine:sodium symporter activity

alanine transmembrane transporter activity [inference]

alanine:sodium symporter activity

L-amino acid transmembrane transporter activity

L-glutamine transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity

neutral L-amino acid:sodium symporter activity

glycine:sodium symporter activity

solute:sodium symporter activity [inference]

amino acid:sodium symporter activity

neutral L-amino acid:sodium symporter activity

glycine:sodium symporter activity

organic acid:sodium symporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

proline:sodium symporter activity

L-amino acid transmembrane transporter activity

L-glutamine transmembrane transporter activity

glycine transmembrane transporter activity [inference]

glycine:sodium symporter activity

alanine transmembrane transporter activity [inference]

alanine:sodium symporter activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MMHFKSGLELTELQNMTVPEDDNVSNDSNDFTEVENGQINSKFISDRESRRSLTNSHLEKRKCDEYIPGTTSLGMSVFNLSNAIMGSGILGLAFALANTGILLFLILLTSVTLLSIYSINLLLICSKETGCMVYEKLGEQVFGTTGKLVIFGATSLQNTGAMLSYLFIVKNELPSAIKSLMGEEDAFSAWYVDGRVLVVMVTFGIILPLCLLKNLGYLGYTSGFSLSCMMFFLIVVIYKKFQTPCMSVEQNSTVSANVTDACTPKYVTFNSKTVYALPTIAFAFVCHPSVLPIYSELKDRSQKKMQMVSNISFFAMFVMYFLTAIFGYLTFYEKVQSDLLHKYQSTGDILILTVRLAVIVAVILTVPVLFFTVRSSLFELAKKTKFHLCRHVLVTIILLIIINLLVIFIPSMKDIFGVVGVTSANMLIFILPSSLYLKITNQDGDKGTQRIWAALFLGLGVLFSLISIPLVIYDWACSSGTDEGH

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites