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Tumor necrosis factor family member eiger

Summary

UniProt ID: Q8MUJ1
Gene Symbol: egr CG12919 Darth
Gene ID: 36054
Organism: Drosophila melanogaster (fruit fly)

External Links

PubChem: Q8MUJ1
Re-Glyco: Q8MUJ1

Annotation

Keyword: 3D-structure Alternative splicing Apoptosis Cell membrane Coiled coil Cytokine Cytoplasmic vesicle Direct protein sequencing Disulfide bond Glycoprotein Innate immunity Reference proteome Secreted Signal-anchor Transmembrane helix Tumor suppressor

Gene Ontology (GO)

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	Reference
response to tumor cell	IMP	PMID
apoptotic process	IDA	PMID
apoptotic process	IMP	PMID PMID
immune response	IMP	PMID
immune response	IBA	GO_REF

GO Hierarchy

biological process

immune system process [inference]

immune response

innate immune response

melanization defense response

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

tumor necrosis factor-mediated signaling pathway

metabolic process [inference]

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanization defense response

secondary metabolic process [inference]

melanin metabolic process [inference]

melanization defense response

pigment metabolic process [inference]

melanin metabolic process [inference]

melanization defense response

cell death [inference]

programmed cell death [inference]

apoptotic process

cell population proliferation [inference]

glial cell proliferation

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

membrane invagination [inference]

plasma membrane invagination [inference]

phagocytosis, engulfment [inference]

engulfment of apoptotic cell

homeostatic process [inference]

cellular homeostasis [inference]

neuron cellular homeostasis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

melanization defense response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

melanization defense response

response to wounding [inference]

wound healing

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

response to amino acid starvation [inference]

cellular response to amino acid starvation

immune response

innate immune response

melanization defense response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

melanization defense response

response to biotic stimulus [inference]

response to tumor cell

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

melanization defense response

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

response to amino acid starvation [inference]

cellular response to amino acid starvation

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade [inference]

positive regulation of JNK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

negative regulation of neuromuscular synaptic transmission

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

negative regulation of synaptic transmission [inference]

negative regulation of neuromuscular synaptic transmission

regulation of neuromuscular synaptic transmission [inference]

negative regulation of neuromuscular synaptic transmission

regulation of growth [inference]

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

regulation of developmental growth [inference]

regulation of multicellular organism growth [inference]

negative regulation of multicellular organism growth

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of programmed cell death

positive regulation of apoptotic process

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell maturation [inference]

positive regulation of neuron maturation [inference]

positive regulation of neuron remodeling

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell maturation [inference]

positive regulation of neuron maturation [inference]

positive regulation of neuron remodeling

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system process [inference]

positive regulation of sensory perception of pain

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

negative regulation of neuromuscular synaptic transmission

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of neuromuscular synaptic transmission

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

negative regulation of multicellular organismal process [inference]

negative regulation of multicellular organism growth

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade [inference]

positive regulation of JNK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell maturation [inference]

positive regulation of neuron maturation [inference]

positive regulation of neuron remodeling

regulation of neuron differentiation [inference]

regulation of neuron maturation [inference]

positive regulation of neuron maturation [inference]

positive regulation of neuron remodeling

regulation of neuron remodeling [inference]

positive regulation of neuron remodeling

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of cell maturation [inference]

positive regulation of neuron maturation [inference]

positive regulation of neuron remodeling

regulation of cell maturation [inference]

regulation of neuron maturation [inference]

positive regulation of neuron maturation [inference]

positive regulation of neuron remodeling

regulation of neuron remodeling [inference]

positive regulation of neuron remodeling

positive regulation of cell maturation [inference]

positive regulation of neuron maturation [inference]

positive regulation of neuron remodeling

regulation of developmental growth [inference]

regulation of multicellular organism growth [inference]

negative regulation of multicellular organism growth

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell maturation [inference]

positive regulation of neuron maturation [inference]

positive regulation of neuron remodeling

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

tumor necrosis factor-mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade [inference]

positive regulation of JNK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of neuromuscular synaptic transmission

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

negative regulation of synaptic transmission [inference]

negative regulation of neuromuscular synaptic transmission

regulation of neuromuscular synaptic transmission [inference]

negative regulation of neuromuscular synaptic transmission

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of reactive oxygen species biosynthetic process

regulation of reactive oxygen species biosynthetic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of reactive oxygen species biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

regulation of reactive oxygen species metabolic process [inference]

regulation of reactive oxygen species biosynthetic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of reactive oxygen species biosynthetic process

positive regulation of reactive oxygen species metabolic process

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death

positive regulation of apoptotic process

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell maturation [inference]

positive regulation of neuron maturation [inference]

positive regulation of neuron remodeling

regulation of neuron differentiation [inference]

regulation of neuron maturation [inference]

positive regulation of neuron maturation [inference]

positive regulation of neuron remodeling

regulation of neuron remodeling [inference]

positive regulation of neuron remodeling

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of cell maturation [inference]

positive regulation of neuron maturation [inference]

positive regulation of neuron remodeling

regulation of cell maturation [inference]

regulation of neuron maturation [inference]

positive regulation of neuron maturation [inference]

positive regulation of neuron remodeling

regulation of neuron remodeling [inference]

positive regulation of neuron remodeling

positive regulation of cell maturation [inference]

positive regulation of neuron maturation [inference]

positive regulation of neuron remodeling

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of programmed cell death

positive regulation of apoptotic process

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell maturation [inference]

positive regulation of neuron maturation [inference]

positive regulation of neuron remodeling

positive regulation of cell motility [inference]

positive regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of neuromuscular synaptic transmission

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of multicellular organismal process [inference]

regulation of multicellular organism growth [inference]

negative regulation of multicellular organism growth

regulation of system process [inference]

regulation of nervous system process [inference]

positive regulation of nervous system process [inference]

positive regulation of sensory perception of pain

regulation of sensory perception [inference]

regulation of sensory perception of pain [inference]

positive regulation of sensory perception of pain

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system process [inference]

positive regulation of sensory perception of pain

negative regulation of multicellular organismal process [inference]

negative regulation of multicellular organism growth

Displaying **all 5** entries
GO Term	Evidence Code	Reference
obsolete extracellular space
plasma membrane	IDA	PMID PMID PMID PMID
plasma membrane	IEA	GO_REF
cytoplasmic vesicle	EXP	PMID
cytoplasmic vesicle	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
signaling receptor binding	IDA	PMID
cytokine activity	IBA	GO_REF
tumor necrosis factor receptor binding	IEA	GO_REF
tumor necrosis factor receptor superfamily binding	ISS	PMID
tumor necrosis factor receptor superfamily binding	IDA	PMID

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding

cytokine receptor binding [inference]

tumor necrosis factor receptor superfamily binding

tumor necrosis factor receptor binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

cytokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

cytokine activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MTAETLKPFITPTSANDDGFPAKATSTATAQRRTRQLIPLVLGFIGLGLVVAILALTIWQTTRVSHLDKELKSLKRVVDNLQQRLGINYLDEFDEFQKEYENALIDYPKKVDGLTDEEDDDDGDGLDSIADDEDDDVSYSSVDDVGADYEDYTDMLNKLNNAHTGTTPTSETTAEGEGETDSASSASNDDNVFDDFTSYNAHKKKQERKSRSIADVRNEEQNIQGNHTELQEKSSNEATSKESPAPLHHRRRMHSRHRHLLVRKGESLLSARSEDSRPAAHFHLSSRRRHQGSMGYHGDMYIGNDNERNSYQGHFQTRDGVLTVTNTGLYYVYAQICYNNSHDQNGFIVFQGDTPFLQCLNTVPTNMPHKVHTCHTSGLIHLERNERIHLKDIHNDRNAVLREGNNRSYFGIFKV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	Source
226	N-linked (GlcNAc...) asparagine	UniProt
339	N-linked (GlcNAc...) asparagine	UniProt
406	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
HuR (ELAVL1) binds and stabilizes mRNA	Drosophila melanogaster

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:305	carcinoma	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

International Collaboration

Acknowledgements