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Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

Summary

UniProt ID

Q8NAT1

Gene Symbol

AGO61
C3orf39
EOGTL
GTDC2
POMGNT2

Gene ID

[84892]

Organism

Homo sapiens (human)

External Links

GlyGen: Q8NAT1
PubChem: Q8NAT1
The Human Metabolome Database: HMDBP11759
The O-GlcNAc Database: Q8NAT1
O-GlcNAcAtlas: Q8NAT1
Re-Glyco: Q8NAT1

Annotation

Keyword: 3D-structure Congenital muscular dystrophy Disease variant Dystroglycanopathy Endoplasmic reticulum Glycoprotein Glycosyltransferase Limb-girdle muscular dystrophy Lissencephaly Proteomics identification Reference proteome Signal-anchor Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
neuron migration	ISS	GO_REF
neuron migration	IEA	GO_REF
protein O-linked glycosylation	TAS	Reactome
protein O-linked glycosylation	IDA	PMID
protein O-linked glycosylation	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via mannose

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via mannose

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via mannose

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via mannose

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via mannose

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via mannose

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via mannose

cell motility [inference]

cell migration [inference]

neuron migration

Displaying **all 5** entries
GO Term	Evidence Code	Reference
endoplasmic reticulum	IDA	PMID PMID
endoplasmic reticulum	IBA	GO_REF
endoplasmic reticulum membrane	EXP	PMID PMID
endoplasmic reticulum membrane	TAS	Reactome
endoplasmic reticulum membrane	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
acetylglucosaminyltransferase activity	IDA	PMID
acetylglucosaminyltransferase activity	IEA	GO_REF
protein O-acetylglucosaminyltransferase activity	TAS	Reactome
protein O-acetylglucosaminyltransferase activity	IDA	PMID
protein O-acetylglucosaminyltransferase activity	IMP	PMID

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity

protein O-acetylglucosaminyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity

protein O-acetylglucosaminyltransferase activity

catalytic activity, acting on a protein [inference]

protein O-acetylglucosaminyltransferase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MHLSAVFNALLVSVLAAVLWKHVRLREHAATLEEELALSRQATEPAPALRIDYPKALQILMEGGTHMVCTGRTHTDRICRFKWLCYSNEAEEFIFFHGNTSVMLPNLGSRRFQPALLDLSTVEDHNTQYFNFVELPAAALRFMPKPVFVPDVALIANRFNPDNLMHVFHDDLLPLFYTLRQFPGLAHEARLFFMEGWGEGAHFDLYKLLSPKQPLLRAQLKTLGRLLCFSHAFVGLSKITTWYQYGFVQPQGPKANILVSGNEIRQFARFMTEKLNVSHTGVPLGEEYILVFSRTQNRLILNEAELLLALAQEFQMKTVTVSLEDHTFADVVRLVSNASMLVSMHGAQLVTTLFLPRGATVVELFPYAVNPDHYTPYKTLAMLPGMDLQYVAWRNMMPENTVTHPERPWDQGGITHLDRAEQARILQSREVPRHLCCRNPEWLFRIYQDTKVDIPSLIQTIRRVVKGRPGPRKQKWTVGLYPGKVREARCQASVHGASEARLTVSWQIPWNLKYLKVREVKYEVWLQEQGENTYVPYILALQNHTFTENIKPFTTYLVWVRCIFNKILLGPFADVLVCNT

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
39		23584533	G57321FI	GlyGen
41		23584533	G57321FI	GlyGen
43		23584533 35289036	G49108TO G57321FI	GlyGen The O-GlcNAc Database
99	N-linked (GlcNAc...) asparagine			UniProt GlyGen
276	N-linked (GlcNAc...) asparagine	24190977 37074911	G62765YT G31852PQ G41247ZX	UniProt GlyGen
337		37074911	G40926MX G40574BA G80920RR	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
DAG1 core M3 glycosylations	Homo sapiens

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0112382	muscular dystrophy-dystroglycanopathy type C8	Alliance of Genome Resources
DOID:0111231	congenital muscular dystrophy-dystroglycanopathy type A8	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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External Links

Annotation

International Collaboration

Acknowledgements