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Neuropilin-1a

Summary

UniProt ID

Q8QFX6

Gene Symbol

np-1
nrp1
nrp1a

Gene ID

[""]

Organism

Danio rerio (zebrafish)

External Links

PubChem: Q8QFX6
Re-Glyco: Q8QFX6

Annotation

Keyword: Angiogenesis Calcium Developmental protein Differentiation Disulfide bond Heparan sulfate Heparin-binding Metal-binding Neurogenesis Receptor Reference proteome Repeat Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 30 in total

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GO Term	Evidence Code	Reference
angiogenesis	IEA	GO_REF
vasculogenesis	IBA	GO_REF
response to hypoxia
neural crest cell migration	IBA	GO_REF
cell activation

GO Hierarchy

biological process

cellular process [inference]

cell activation

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

vascular endothelial growth factor receptor signaling pathway

cell recognition [inference]

neuron recognition [inference]

axonal fasciculation

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

mesenchymal cell migration [inference]

neural crest cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

neuron projection fasciculation [inference]

axonal fasciculation

multicellular organismal process [inference]

cell activation

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

forebrain development

animal organ development [inference]

heart development [inference]

larval heart development

hematopoietic or lymphoid organ development [inference]

thymus development

gland development [inference]

thymus development

cartilage development

system development [inference]

vasculature development

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

developmental growth involved in morphogenesis [inference]

neuron projection extension [inference]

axon extension

response to stimulus [inference]

response to stress [inference]

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of vascular endothelial growth factor receptor signaling pathway

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of blood vessel endothelial cell migration [inference]

positive regulation of cell migration involved in sprouting angiogenesis

regulation of chemotaxis [inference]

regulation of axon guidance [inference]

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of blood vessel endothelial cell migration [inference]

positive regulation of cell migration involved in sprouting angiogenesis

regulation of blood vessel endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration [inference]

positive regulation of cell migration involved in sprouting angiogenesis

regulation of cell migration involved in sprouting angiogenesis [inference]

positive regulation of cell migration involved in sprouting angiogenesis

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of blood vessel endothelial cell migration [inference]

positive regulation of cell migration involved in sprouting angiogenesis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of blood vessel endothelial cell migration [inference]

positive regulation of cell migration involved in sprouting angiogenesis

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of blood vessel endothelial cell migration [inference]

positive regulation of cell migration involved in sprouting angiogenesis

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of blood vessel endothelial cell migration [inference]

positive regulation of cell migration involved in sprouting angiogenesis

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of vascular endothelial growth factor receptor signaling pathway

regulation of response to external stimulus [inference]

regulation of chemotaxis [inference]

regulation of axon guidance [inference]

regulation of cellular response to growth factor stimulus [inference]

regulation of vascular endothelial growth factor receptor signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

vascular endothelial growth factor receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of vascular endothelial growth factor receptor signaling pathway

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of filopodium assembly [inference]

positive regulation of filopodium assembly

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of blood vessel endothelial cell migration [inference]

positive regulation of cell migration involved in sprouting angiogenesis

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of filopodium assembly [inference]

positive regulation of filopodium assembly

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of axonogenesis

regulation of axon guidance [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of filopodium assembly [inference]

positive regulation of filopodium assembly

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of blood vessel endothelial cell migration [inference]

positive regulation of cell migration involved in sprouting angiogenesis

regulation of blood vessel endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration [inference]

positive regulation of cell migration involved in sprouting angiogenesis

regulation of cell migration involved in sprouting angiogenesis [inference]

positive regulation of cell migration involved in sprouting angiogenesis

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of blood vessel endothelial cell migration [inference]

positive regulation of cell migration involved in sprouting angiogenesis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of blood vessel endothelial cell migration [inference]

positive regulation of cell migration involved in sprouting angiogenesis

regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis

Displaying **all 3** entries
GO Term	Evidence Code	Reference
plasma membrane	IBA	GO_REF
focal adhesion	IBA	GO_REF
axon	IBA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
vascular endothelial growth factor receptor activity	IDA	PMID
vascular endothelial growth factor receptor activity	IBA	GO_REF
vascular endothelial growth factor receptor activity	IEA	GO_REF
heparin binding
semaphorin receptor activity	IBA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

vascular endothelial growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

vascular endothelial growth factor receptor activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

vascular endothelial growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

vascular endothelial growth factor receptor activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

vascular endothelial growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

vascular endothelial growth factor receptor activity

binding [inference]

protein binding [inference]

growth factor binding [inference]

vascular endothelial growth factor binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

semaphorin receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

vascular endothelial growth factor receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MHCGLVLILFTGIFLIVSALKNDKCGDNIRITSANYLTSPGYPVSYYPSQKCIWVITAPGPNQRILINFNPHFDLEDRECKYDYVEVRDGVDENGQLVGKYCGKIAPSPVVSSGNQLFIKFVSDYETHGAGFSIRYEIFKTGPECSRNFTSSSGVIKSPGFPEKYPNNLDCTFMIFAPKMSEIVLEFESFELEPDTQPPAGVFCRYDRLEIWDGFPGVGPYIGRYCGQNTPGRIISYTGTLAMTINTDSAIAKEGFSANFTVLERTVPDDFDCTEPLGMETGEIHSDQIMASSQYSNSWSAERSRLNNPENGWTPLKDTNKEWIQVDLGFLRFVSAIGTQGAISQETKKKYYVKEYKVDVSSNGEDWITIKDGPKQKLFQGNTNPTDVVKAKFPKPTLTRYLRIRPINWETGIALRFEVYGCKISEYPCSGMLGMVSGLITDSQITVSSHIERTWVSENARLLTSRSGWMLLPQSQPYADEWLQIDLAEEKLVKGLIIQGGKHRDNKVFMKKFRLGYSNNGSDWKLVMDATGNKPKIFEGNLNYDTPALRTMEPVLTRFVRIYPDRGTPAGMGLRLELLGCEMEVPTVPPTTPAASTTPSDECDDDQANCHSGTGDGYDQTGGTTATETIREMSTIPAFLWFACDFGWANDPSFCGWISEDSGFRWQIQSSGTPTLNTGPNMDHTGGSGNFIYTLATGAQETEVARLVSPSVSGQDSDLCLSFWYHMFGSHIGTLHIKQRRETSQGSADVLLWTVSGHQGNRWREGRVLIPHSNKPYQVIIESVVERKSWGDIAVDDIKILDNVNMADCKDPDVPAEPIQPEDNFNEIMVDITDFPDIVENPDIGGAGNMLKTLDPILITIIAMSALGVFLGAICGVVLYCACSHSGMSDRNLSALENYNFELVDGVKLKKDKLNSQNSYSEA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	Source
148	N-linked (GlcNAc...) asparagine	UniProt
259	N-linked (GlcNAc...) asparagine	UniProt
520	N-linked (GlcNAc...) asparagine	UniProt
612	O-linked (Xyl...) (chondroitin sulfate) serine; alternate O-linked (Xyl...) (heparan sulfate) serine; alternate	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
CRMPs in Sema3A signaling	Danio rerio
Neuropilin interactions with VEGF and VEGFR	Danio rerio
Sema3A PAK dependent Axon repulsion	Danio rerio

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

Annotation

International Collaboration

Acknowledgements