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Integrin beta-6

Summary

UniProt ID

Q8SQB8

Gene Symbol

ITGB6

Gene ID

[282644]

Organism

Bos taurus (domestic cattle)

External Links

PubChem: Q8SQB8
Re-Glyco: Q8SQB8

Annotation

Keyword: Calcium Cell adhesion Cell junction Cell membrane Disulfide bond EGF-like domain Glycoprotein Host cell receptor for virus entry Host-virus interaction Integrin Magnesium Metal-binding Reference proteome Repeat Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	Reference
cell morphogenesis
inflammatory response
cell-matrix adhesion	IBA	GO_REF
transforming growth factor beta receptor signaling pathway
integrin-mediated signaling pathway	IBA	GO_REF

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

leukocyte activation [inference]

myeloid leukocyte activation [inference]

myeloid dendritic cell activation [inference]

myeloid dendritic cell differentiation [inference]

Langerhans cell differentiation

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

T cell activation [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

immunological memory process [inference]

immunological memory formation process [inference]

memory T cell differentiation

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

leukocyte activation [inference]

myeloid leukocyte activation [inference]

myeloid dendritic cell activation [inference]

myeloid dendritic cell differentiation [inference]

Langerhans cell differentiation

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

T cell activation [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

cell adhesion [inference]

cell-substrate adhesion [inference]

cell-matrix adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

integrin-mediated signaling pathway

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

transforming growth factor beta production

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

transforming growth factor beta production

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

myeloid dendritic cell differentiation [inference]

Langerhans cell differentiation

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

dendritic cell differentiation [inference]

myeloid dendritic cell differentiation [inference]

Langerhans cell differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

myeloid dendritic cell differentiation [inference]

Langerhans cell differentiation

cell motility [inference]

cell migration

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to ionizing radiation

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

leukocyte activation [inference]

myeloid leukocyte activation [inference]

myeloid dendritic cell activation [inference]

myeloid dendritic cell differentiation [inference]

Langerhans cell differentiation

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

T cell activation [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

cytokine production [inference]

transforming growth factor beta production

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

surfactant homeostasis

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

tooth mineralization [inference]

enamel mineralization

tube development [inference]

respiratory tube development [inference]

bronchiole development

lung alveolus development

animal organ development [inference]

respiratory tube development [inference]

bronchiole development

hard palate development

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

myeloid dendritic cell differentiation [inference]

Langerhans cell differentiation

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

dendritic cell differentiation [inference]

myeloid dendritic cell differentiation [inference]

Langerhans cell differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

myeloid dendritic cell differentiation [inference]

Langerhans cell differentiation

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

surfactant homeostasis

chemical homeostasis [inference]

lipid homeostasis [inference]

phospholipid homeostasis

multicellular organismal-level chemical homeostasis [inference]

surfactant homeostasis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

response to wounding [inference]

wound healing

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

response to abiotic stimulus [inference]

response to radiation [inference]

response to ionizing radiation [inference]

cellular response to ionizing radiation

cellular response to radiation [inference]

cellular response to ionizing radiation

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to ionizing radiation

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to ionizing radiation

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

integrin-mediated signaling pathway

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
focal adhesion	ISS	GO_REF
focal adhesion	IBA	GO_REF
focal adhesion	IEA	GO_REF GO_REF
external side of plasma membrane	IEA	GO_REF
cell surface	IBA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex [inference]

integrin alphav-beta6 complex

protein complex involved in cell adhesion [inference]

integrin complex [inference]

integrin alphav-beta6 complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex [inference]

integrin alphav-beta6 complex

cellular anatomical structure [inference]

cell surface

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

side of membrane [inference]

external side of plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	Reference
virus receptor activity
integrin binding	IBA	GO_REF
integrin binding	IEA	GO_REF
metal ion binding
molecular function activator activity	IEA	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

integrin binding

cell adhesion molecule binding [inference]

integrin binding

exogenous protein binding [inference]

virus receptor activity

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

integrin binding

molecular function regulator activity [inference]

molecular function activator activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGIELLCLFFLCLGRNDHVQGGCAVGGAETCEDCLLIGPQCAWCSQENFTHLSGVGERCDTPANLLAKGCQLTFIENPVSQVEILTNKPLSIGRQKNSSDIVQISPQSLALKLRPGLEQTLQVQVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSLLSKEMSKLTSNFRLGFGSFVEKPISPFMKTTPEEIANPCSSIPYFCLPTFGFKHILPLTNDAERFNEIVKNQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDSKNEYSMSTILEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYENYAKLIPGATVGVLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTAICNTGIPVPHQKKCSHMKVGDTASFNVTVSLPNCERRSRHIILKPVGLGDALEILVSPECSCDCQKEVEVNSSKCNNGNGSFQCGVCACHPGHMGHHCECGEDTLSTESCKEAPGRPSCSGRGDCYCGQCVCHLSPYGNIYGPYCQCDNFSCVRHKGLLCGDNGDCDCGECVCRSGWTGEYCNCTTSTDPCVSEDGILCSGRGDCVCGKCICTNPGASGPTCERCPTCGDPCNSKRSCIECYLSADGQAQEECVDKCKLAGATINEEEDFSKDSFVSCSLQGENECLITFLLTTDNEGKTVIHSINEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRKEVAKFEAERSKAKWQTGTNPLYRGSTSTFKNVTYKHKEKQKVDLSTDG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 9** entries
Position	Description	Source
48	N-linked (GlcNAc...) asparagine	UniProt
97	N-linked (GlcNAc...) asparagine	UniProt
260	N-linked (GlcNAc...) asparagine	UniProt
387	N-linked (GlcNAc...) asparagine	UniProt
418	N-linked (GlcNAc...) asparagine	UniProt
463	N-linked (GlcNAc...) asparagine	UniProt
471	N-linked (GlcNAc...) asparagine	UniProt
541	N-linked (GlcNAc...) asparagine	UniProt
575	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
ECM proteoglycans	Bos taurus
Elastic fibre formation	Bos taurus
Integrin cell surface interactions	Bos taurus
Molecules associated with elastic fibres	Bos taurus
TGF-beta receptor signaling activates SMADs	Bos taurus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

Annotation

International Collaboration

Acknowledgements