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Fibroblast growth factor receptor substrate 2

Summary

UniProt ID

Q8WU20

Gene Symbol

FRS2

Organism

Homo sapiens (human)

External Links

GlyGen: Q8WU20
PubChem: Q8WU20
The O-GlcNAc Database: Q8WU20
RaftProt: Q8WU20
O-GlcNAcAtlas: Q8WU20

Annotation

Keyword

3D-structure
Membrane
Myristate
Phosphoprotein
Reference proteome
Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 10** of 18 in total

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GO Term
regulation of ERK1 and ERK2 cascade
lens fiber cell development
positive regulation of vascular associated smooth muscle cell proliferation
negative regulation of cardiac muscle cell differentiation
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
lens placode formation involved in camera-type eye formation
organ induction
fibroblast growth factor receptor signaling pathway
transmembrane receptor protein tyrosine phosphatase signaling pathway
positive regulation of MAPK cascade

Displaying **all 7** entries
GO Term
cytosol
adherens junction
cytoplasm
plasma membrane
cell-cell junction
endomembrane system
membrane

Displaying **all 4** entries
GO Term
phosphatase activator activity
fibroblast growth factor receptor binding
transmembrane receptor protein tyrosine kinase adaptor activity
neurotrophin TRKA receptor binding

Annotation information from UniProt.

Sequence

MGSCCSCPDKDTVPDNHRNKFKVINVDDDGNELGSGIMELTDTELILYTRKRDSVKWHYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELFNMLQEIMQNNSINVVEEPVVERNNHQTELEVPRTPRTPTTPGFAAQNLPNGYPRYPSFGDASSHPSSRHPSVGSARLPSVGEESTHPLLVAEEQVHTYVNTTGVQEERKNRTSVHVPLEARVSNAESSTPKEEPSSIEDRDPQILLEPEGVKFVLGPTPVQKQLMEKEKLEQLGRDQVSGSGANNTEWDTGYDSDERRDAPSVNKLVYENINGLSIPSASGVRRGRLTSTSTSDTQNINNSAQRRTALLNYENLPSLPPVWEARKLSRDEDDNLGPKTPSLNGYHNNLDPMHNYVNTENVTVPASAHKIEYSRRRDCTPTVFNFDIRRPSLEHRQLNYIQVDLEGGSDSDNPQTPKTPTTPLPQTPTRRTELYAVIDIERTAAMSNLQKALPRDDGTSRKTRHNSTDLPM

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
177			G49108TO	GlyGen The O-GlcNAc Database
329			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **21 - 28** of 28 in total

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Pathway Name	Organism
RND1 GTPase cycle	Homo sapiens
RND2 GTPase cycle	Homo sapiens
Signaling by ALK	Homo sapiens
Signaling by ALK fusions and activated point mutants	Homo sapiens
Signaling by FGFR1 in disease	Homo sapiens
Signaling by FGFR2 in disease	Homo sapiens
Signaling by FGFR3 in disease	Homo sapiens
Signaling by FGFR4 in disease	Homo sapiens