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Cadherin-2

Summary

UniProt ID: Q90275
Gene Symbol: cdh2 pac
Gene ID: 30291
Organism: Danio rerio (zebrafish)

External Links

PubChem: Q90275
Re-Glyco: Q90275

Annotation

Keyword: Calcium Cell adhesion Cell junction Cell membrane Cell projection Cleavage on pair of basic residues Developmental protein Differentiation Glycoprotein Metal-binding Neurogenesis Reference proteome Repeat Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 68 in total

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GO Term	Evidence Code	Reference
cell morphogenesis	IMP	PMID
cell morphogenesis	IBA	GO_REF
cartilage condensation	IMP	PMID
neural crest cell migration	IGI	PMID
somitogenesis	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

establishment or maintenance of cell polarity [inference]

establishment of cell polarity [inference]

establishment of monopolar cell polarity [inference]

establishment of apical/basal cell polarity [inference]

establishment of epithelial cell apical/basal polarity

establishment of epithelial cell polarity [inference]

establishment of epithelial cell apical/basal polarity

establishment or maintenance of bipolar cell polarity [inference]

establishment or maintenance of apical/basal cell polarity [inference]

establishment of apical/basal cell polarity [inference]

establishment of epithelial cell apical/basal polarity

establishment or maintenance of epithelial cell apical/basal polarity [inference]

establishment of epithelial cell apical/basal polarity

establishment or maintenance of monopolar cell polarity [inference]

establishment of monopolar cell polarity [inference]

establishment of apical/basal cell polarity [inference]

establishment of epithelial cell apical/basal polarity

cell recognition [inference]

neuron recognition [inference]

axonal fasciculation

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation

neurogenesis [inference]

generation of neurons

epithelial cell differentiation [inference]

polarized epithelial cell differentiation [inference]

establishment of epithelial cell apical/basal polarity

cardiocyte differentiation [inference]

cardioblast differentiation

stem cell differentiation [inference]

cardioblast differentiation

cell development [inference]

pigment cell development

cell motility [inference]

cell migration

ameboidal-type cell migration [inference]

cell migration involved in gastrulation [inference]

dorsal convergence

mesenchymal cell migration [inference]

neural crest cell migration

neuron migration

motor neuron migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cilium organization [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

cell junction assembly [inference]

organelle assembly [inference]

cilium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

inner ear receptor cell stereocilium organization [inference]

auditory receptor cell stereocilium organization

neuron projection guidance [inference]

axon guidance

neuron projection fasciculation [inference]

axonal fasciculation

cilium organization [inference]

cilium assembly

plasma membrane bounded cell projection assembly [inference]

cilium assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction organization [inference]

synapse organization [inference]

synapse assembly

cell aggregation [inference]

cartilage condensation

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

anterior/posterior pattern specification [inference]

somitogenesis

spinal cord patterning

segmentation [inference]

somitogenesis

stem cell population maintenance [inference]

neuronal stem cell population maintenance

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis

animal organ morphogenesis [inference]

odontogenesis

embryonic organ morphogenesis [inference]

embryonic eye morphogenesis

sensory organ morphogenesis [inference]

eye morphogenesis [inference]

embryonic eye morphogenesis

appendage morphogenesis [inference]

fin morphogenesis [inference]

pectoral fin morphogenesis [inference]

embryonic pectoral fin morphogenesis

medial fin morphogenesis [inference]

dorsal fin morphogenesis

embryonic appendage morphogenesis [inference]

embryonic pectoral fin morphogenesis

tube morphogenesis [inference]

semicircular canal morphogenesis

post-anal tail morphogenesis

embryonic morphogenesis [inference]

embryonic appendage morphogenesis [inference]

embryonic pectoral fin morphogenesis

embryonic organ morphogenesis [inference]

embryonic eye morphogenesis

tissue morphogenesis [inference]

mesoderm morphogenesis

anatomical structure arrangement [inference]

hindbrain structural organization

mesoderm structural organization [inference]

axial mesoderm structural organization

anatomical structure formation involved in morphogenesis [inference]

somitogenesis

tube formation [inference]

epithelial tube formation [inference]

embryonic epithelial tube formation [inference]

neural tube formation

anatomical structure development [inference]

tissue development [inference]

ectoderm development

epithelium development [inference]

neural tube development

epithelium regeneration [inference]

sensory epithelium regeneration

regeneration [inference]

tissue regeneration

epithelium regeneration [inference]

sensory epithelium regeneration

tube development [inference]

neural tube development

cell development [inference]

pigment cell development

animal organ development [inference]

brain development

system development [inference]

retina development in camera-type eye

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation

neurogenesis [inference]

generation of neurons

epithelial cell differentiation [inference]

polarized epithelial cell differentiation [inference]

establishment of epithelial cell apical/basal polarity

cardiocyte differentiation [inference]

cardioblast differentiation

stem cell differentiation [inference]

cardioblast differentiation

cell development [inference]

pigment cell development

maintenance of cell number [inference]

stem cell population maintenance [inference]

neuronal stem cell population maintenance

growth [inference]

developmental growth [inference]

tissue regeneration

epithelium regeneration [inference]

sensory epithelium regeneration

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of neural precursor cell proliferation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of neuron differentiation [inference]

regulation of photoreceptor cell differentiation [inference]

regulation of eye photoreceptor cell development

regulation of cell development [inference]

regulation of eye photoreceptor cell development

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of neural precursor cell proliferation

regulation of neural precursor cell proliferation [inference]

negative regulation of neural precursor cell proliferation

regulation of cell differentiation [inference]

regulation of neuron differentiation [inference]

regulation of photoreceptor cell differentiation [inference]

regulation of eye photoreceptor cell development

regulation of cell development [inference]

regulation of eye photoreceptor cell development

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of neural precursor cell proliferation

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	Reference
cytoplasm	IBA	GO_REF
cytoplasm	IEA	GO_REF
plasma membrane	ISS	GO_REF
plasma membrane	IDA	PMID PMID PMID
plasma membrane	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

catenin complex

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

sarcolemma

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction

cell-cell contact zone [inference]

intercalated disc

cell projection [inference]

plasma membrane bounded cell projection [inference]

Displaying **all 4** entries
GO Term	Evidence Code	Reference
calcium ion binding	ISS	GO_REF
calcium ion binding	IEA	GO_REF
beta-catenin binding	IBA	GO_REF
cadherin binding	IBA	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

beta-catenin binding

cell adhesion molecule binding [inference]

cadherin binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MYPSGGVMLGLLAALQVAVQGTGAMPCQPGFTENEYNVMTADVITEGQVLLKVDFVDCGRGSGLRFESGDPADFRIDADGTVMAARTLQLTDRKGQSLEIKAKDENSQEQWMVHINFTQPKQVPVILFPRHSVLVKGDDSVNRVKRDWVIPPVNVLENSRKQFPEELVKIQSDKDKSNTLRYSVTGPGADQNPTGLFIIDPISGLLSVTKPLDREHIPNFHLRAHAVDINGNQMENPIDIIINVIDMNDNRPEFTHQIWNGTVDEGAKPGTFVMTVTSQDKDDPNTANGMLRYKILSQTPESPSSNMFTINNKTGKIITVAAGLDREKVPQYTLIIQATDMEGNPTYGLSNTATAVIRLLDVNDNAPEFTRETFHGEVPENRVNVIVTNLTVTDKDEPGTPAWNAVYRIISGDPTGRFSIPTDPVTNEGLVTVVKPVDFEMNRSFMLTVVADNEVPLASGIHRTRQSTATVSIRVIDVNESPNFDPNPKQIKLEEGLPQWSMLTTFTAHDPDRYMQQTISYSKLYDPANWLEIDPNNGRISTIAVLDRESPYVKNNLYNATFMASDNGVPRASGTGTLQIYLLDINDNAPRVFPQEAEVCERPEPNAINITAVDGDLNPNAGPYAFELPNRPSDIRRNWTLTRISGDHAQLSLKISYLESGIYELPISITDSGNLPMSNTTYLRIKVCQCDHHGDCVDMERIMAAGLGTGAIIAILICIIILLVLVLMFVMWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPDTLEPDMIKPVGIRRLDERPMHSEPNYPIRSAAPHPGDIGEFIHEGLKAADTDPTAPPYDSLLVFDYEGSGSTAGSLSSLHSSSSGGDQDYDYLNDWGPRFRKLADMYGGNDD

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 8** entries
Position	Description	Source
260	N-linked (GlcNAc...) asparagine	UniProt
312	N-linked (GlcNAc...) asparagine	UniProt
389	N-linked (GlcNAc...) asparagine	UniProt
442	N-linked (GlcNAc...) asparagine	UniProt
559	N-linked (GlcNAc...) asparagine	UniProt
609	N-linked (GlcNAc...) asparagine	UniProt
638	N-linked (GlcNAc...) asparagine	UniProt
679	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Adherens junctions interactions	Danio rerio
Myogenesis	Danio rerio
Post-translational protein phosphorylation	Danio rerio
Regulation of IGF Activity by IGFBP	Danio rerio

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

International Collaboration

Acknowledgements