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Fibroblast growth factor receptor 1-A

Summary

UniProt ID

Q90Z00

Gene Symbol

fgfr1
fgfr1a
si:ch211-198o12.1

Gene ID

[30705]

Organism

Danio rerio (zebrafish)

External Links

PubChem: Q90Z00
The Human Metabolome Database: HMDBP12141
Re-Glyco: Q90Z00

Annotation

Keyword: ATP-binding Alternative splicing Cell membrane Cytoplasm Cytoplasmic vesicle Disulfide bond Glycoprotein Immunoglobulin domain Nucleus Phosphoprotein Receptor Reference proteome Repeat Signal Transmembrane helix Tyrosine-protein kinase Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 5** of 28 in total

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GO Term	Evidence Code	Reference
liver development	IMP	PMID
liver development	IEA	GO_REF
mesoderm development	IGI	PMID
mesoderm development	IEA	GO_REF
positive regulation of cell population proliferation	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

cell motility [inference]

cell migration [inference]

cell migration in hindbrain

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

dorsal/ventral pattern formation

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

skin morphogenesis

post-anal tail morphogenesis

embryonic morphogenesis [inference]

olfactory placode morphogenesis

ectodermal placode morphogenesis [inference]

olfactory placode morphogenesis

anatomical structure formation involved in morphogenesis [inference]

cranial nerve formation [inference]

olfactory nerve formation

anatomical structure development [inference]

tissue development [inference]

mesoderm development

lateral line development [inference]

posterior lateral line development

muscle tissue development [inference]

striated muscle tissue development [inference]

cardiac muscle tissue development

regeneration [inference]

tissue regeneration [inference]

fin regeneration

animal organ development [inference]

gland development [inference]

liver development

cartilage development

appendage development [inference]

fin development [inference]

pectoral fin development

limb development [inference]

pectoral fin development

growth [inference]

developmental growth [inference]

tissue regeneration [inference]

fin regeneration

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis

response to stimulus [inference]

response to chemical [inference]

response to oxygen-containing compound [inference]

response to alcohol [inference]

response to ethanol

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell differentiation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of developmental process [inference]

positive regulation of cell differentiation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification [inference]

negative regulation of endodermal cell fate specification

negative regulation of endodermal cell differentiation [inference]

negative regulation of endodermal cell fate specification

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification [inference]

negative regulation of endodermal cell fate specification

negative regulation of endodermal cell differentiation [inference]

negative regulation of endodermal cell fate specification

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of developmental process [inference]

regulation of cell fate commitment [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification [inference]

negative regulation of endodermal cell fate specification

regulation of cell fate specification [inference]

negative regulation of cell fate specification [inference]

negative regulation of endodermal cell fate specification

regulation of endodermal cell fate specification [inference]

negative regulation of endodermal cell fate specification

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification [inference]

negative regulation of endodermal cell fate specification

negative regulation of endodermal cell differentiation [inference]

negative regulation of endodermal cell fate specification

positive regulation of cell differentiation

regulation of endodermal cell differentiation [inference]

regulation of endodermal cell fate specification [inference]

negative regulation of endodermal cell fate specification

negative regulation of endodermal cell differentiation [inference]

negative regulation of endodermal cell fate specification

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification [inference]

negative regulation of endodermal cell fate specification

negative regulation of endodermal cell differentiation [inference]

negative regulation of endodermal cell fate specification

positive regulation of developmental process [inference]

positive regulation of cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

regulation of cell fate commitment [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification [inference]

negative regulation of endodermal cell fate specification

regulation of cell fate specification [inference]

negative regulation of cell fate specification [inference]

negative regulation of endodermal cell fate specification

regulation of endodermal cell fate specification [inference]

negative regulation of endodermal cell fate specification

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification [inference]

negative regulation of endodermal cell fate specification

negative regulation of endodermal cell differentiation [inference]

negative regulation of endodermal cell fate specification

positive regulation of cell differentiation

regulation of endodermal cell differentiation [inference]

regulation of endodermal cell fate specification [inference]

negative regulation of endodermal cell fate specification

negative regulation of endodermal cell differentiation [inference]

negative regulation of endodermal cell fate specification

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification [inference]

negative regulation of endodermal cell fate specification

negative regulation of endodermal cell differentiation [inference]

negative regulation of endodermal cell fate specification

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
nucleus	IEA	GO_REF
cytosol	IEA	GO_REF
plasma membrane	ISS	PMID GO_REF
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex

cellular anatomical structure [inference]

cytosol

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
fibroblast growth factor receptor activity	IDA	PMID
fibroblast growth factor receptor activity	IBA	GO_REF
fibroblast growth factor receptor activity	IEA	GO_REF
ATP binding	IEA	GO_REF
heparin binding	ISS	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

fibroblast growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

fibroblast growth factor receptor activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

fibroblast growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

fibroblast growth factor receptor activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

fibroblast growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

fibroblast growth factor receptor activity

binding [inference]

protein binding [inference]

growth factor binding [inference]

fibroblast growth factor binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

sulfur compound binding [inference]

heparin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

fibroblast growth factor receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MKMMMIMKTTLLLISVLLTQALQSQGRPAIQDEAPAEPTSYTLDSGEKLELSCKAKEDTQKVTWTKDLVPLVDGEHTRLRNDQMEIEKVEPTDSGLYACFAQGLNSNHTEYFNISVTDEEDEVDSSSEEAKLSNDQNLPMAPVWAQPDKMEKKLHAVPASKTVKFRCQANGNPTPTLKWLKNGKEFKRDQRIGGFKVREHMWTIIMESVVPSDRGNYTCLVENRHGSINHTYQLDVVERSPHRPILQAGLPANRTAVVGSDVEFECKVFSDPQPHIQWLKHIEVNGSRYGPDGLPYVRALKTAGVNTTDKEMEVLQIRNVSLEDAGEYTCLAGNSIGHSHHSAWLTVYKAVPPTQLPNQTYLEVLIYCVGFFLICVMVGTAVLAKMHSSAKKSDFNSQLAVHKLAKSIPLRRQVTVSVDSSSSMHSGGMLVRPSRLSSSGSPMLSGVSEYELPQDPRWEVQRDRLVLGKPLGEGCFGQVMMAEAMGMDKEKPNRITKVAVKMLKSDATEKDLSDLISEMEMMKIIGKHKNIINLLGACTQDGPLYVIVEFAAKGNLREYLRVRRPPGMEYCYNPDQVPVENMSIKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDRPSTCTHELYMMMRDCWHAVPSQRPTFKQLVEDLDRTLSMTSNQEYLDLSVSLDQFSPNFPDTRSSTCSSGEDSVFSHDAGADEPCLPKFPPHPNRGVAFKKR

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 9** entries
Position	Description	Source
107	N-linked (GlcNAc...) asparagine	UniProt
113	N-linked (GlcNAc...) asparagine	UniProt
216	N-linked (GlcNAc...) asparagine	UniProt
229	N-linked (GlcNAc...) asparagine	UniProt
253	N-linked (GlcNAc...) asparagine	UniProt
285	N-linked (GlcNAc...) asparagine	UniProt
306	N-linked (GlcNAc...) asparagine	UniProt
319	N-linked (GlcNAc...) asparagine	UniProt
358	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 13 in total

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Pathway Name	Organism
Downstream signaling of activated FGFR1	Danio rerio
FGFR1b ligand binding and activation	Danio rerio
FGFR1c and Klotho ligand binding and activation	Danio rerio
FGFR1c ligand binding and activation	Danio rerio
FRS-mediated FGFR1 signaling	Danio rerio
Negative regulation of FGFR1 signaling	Danio rerio
PI-3K cascade:FGFR1	Danio rerio
PI3K Cascade	Danio rerio
PI3K/AKT Signaling	Danio rerio
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Danio rerio

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