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Uromodulin

Summary

UniProt ID: Q91X17
Gene Symbol: Umod
Gene ID: 22242
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0007072
PubChem: Q91X17
Re-Glyco: Q91X17

Annotation

Keyword: Cell membrane Cell projection Direct protein sequencing Disulfide bond EGF-like domain GPI-anchor Innate immunity Reference proteome Repeat Secreted Signal

Gene Ontology (GO)

Displaying entries **1 - 5** of 69 in total

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GO Term	Evidence Code	Reference
kidney development	IMP	PMID PMID
organ or tissue specific immune response	IMP	PMID
organ or tissue specific immune response	IEA	GO_REF
renal water homeostasis	IMP	PMID
glomerular filtration	IMP	PMID

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

organ or tissue specific immune response

innate immune response [inference]

antibacterial innate immune response

leukocyte migration [inference]

myeloid leukocyte migration [inference]

granulocyte migration [inference]

neutrophil migration

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

tumor necrosis factor-mediated signaling pathway

apoptotic signaling pathway

metabolic process [inference]

catabolic process [inference]

autophagy

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

macromolecule biosynthetic process [inference]

gene expression

protein metabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

primary metabolic process [inference]

lipid metabolic process

protein metabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

cell death [inference]

programmed cell death [inference]

apoptotic process

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

myeloid leukocyte migration [inference]

granulocyte migration [inference]

neutrophil migration

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport within lipid bilayer [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to membrane raft [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

protein localization to plasma membrane raft [inference]

protein transport into plasma membrane raft

establishment of protein localization to membrane [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

cellular response to stimulus [inference]

cellular response to stress

response to endoplasmic reticulum stress

ERAD pathway

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

transmembrane transport [inference]

urea transmembrane transport

process utilizing autophagic mechanism [inference]

autophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

endoplasmic reticulum organization

membrane organization [inference]

protein transport within lipid bilayer [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal water homeostasis

renal sodium ion transport [inference]

renal sodium ion absorption

renal absorption [inference]

renal sodium ion absorption

renal filtration [inference]

glomerular filtration

renal tubular secretion [inference]

renal urate salt excretion

excretion [inference]

micturition

renal tubular secretion [inference]

renal urate salt excretion

multicellular organismal response to stress

tissue remodeling [inference]

connective tissue replacement

multicellular organismal-level homeostasis

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

renal water homeostasis

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

renal tubule development [inference]

nephron tubule development [inference]

ascending thin limb development [inference]

metanephric ascending thin limb development

thick ascending limb development [inference]

metanephric thick ascending limb development

distal convoluted tubule development [inference]

metanephric distal convoluted tubule development

loop of Henle development

metanephric nephron tubule development [inference]

kidney epithelium development [inference]

nephron epithelium development [inference]

nephron tubule development [inference]

ascending thin limb development [inference]

metanephric ascending thin limb development

thick ascending limb development [inference]

metanephric thick ascending limb development

distal convoluted tubule development [inference]

metanephric distal convoluted tubule development

loop of Henle development

metanephric nephron tubule development [inference]

metanephric nephron epithelium development [inference]

metanephric nephron tubule development [inference]

metanephric epithelium development [inference]

metanephric tubule development [inference]

metanephric nephron tubule development [inference]

metanephric nephron epithelium development [inference]

metanephric nephron tubule development [inference]

tube development [inference]

renal tubule development [inference]

nephron tubule development [inference]

ascending thin limb development [inference]

metanephric ascending thin limb development

thick ascending limb development [inference]

metanephric thick ascending limb development

distal convoluted tubule development [inference]

metanephric distal convoluted tubule development

loop of Henle development

metanephric nephron tubule development [inference]

collecting duct development

metanephric tubule development [inference]

metanephric nephron tubule development [inference]

animal organ development [inference]

kidney development

juxtaglomerular apparatus development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular monoatomic cation homeostasis [inference]

intracellular phosphate ion homeostasis

multicellular organismal-level homeostasis

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

renal water homeostasis

chemical homeostasis

monoatomic ion homeostasis

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular monoatomic cation homeostasis [inference]

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

calcium ion homeostasis

intracellular calcium ion homeostasis

potassium ion homeostasis

sodium ion homeostasis

intracellular sodium ion homeostasis

monoatomic anion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

chloride ion homeostasis

intracellular chloride ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular monoatomic cation homeostasis [inference]

intracellular phosphate ion homeostasis

inorganic ion homeostasis [inference]

phosphate ion homeostasis

intracellular phosphate ion homeostasis

chloride ion homeostasis

intracellular chloride ion homeostasis

calcium ion homeostasis

intracellular calcium ion homeostasis

potassium ion homeostasis

sodium ion homeostasis

intracellular sodium ion homeostasis

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

renal water homeostasis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

antibacterial innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

defense response to bacterium [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

antibacterial innate immune response

response to water deprivation

cellular response to stress

response to endoplasmic reticulum stress

ERAD pathway

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

multicellular organismal response to stress

response to topologically incorrect protein [inference]

response to unfolded protein

cellular response to unfolded protein

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

immune response [inference]

organ or tissue specific immune response

innate immune response [inference]

antibacterial innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

antibacterial innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

antibacterial innate immune response

response to abiotic stimulus [inference]

response to water [inference]

response to water deprivation

response to chemical [inference]

response to acid chemical [inference]

response to water [inference]

response to water deprivation

response to xenobiotic stimulus

response to lipid [inference]

response to lipopolysaccharide

ERAD pathway

response to oxygen-containing compound [inference]

response to water [inference]

response to water deprivation

response to lipopolysaccharide

cellular response to stimulus [inference]

cellular response to stress

response to endoplasmic reticulum stress

ERAD pathway

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport within lipid bilayer [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

protein localization to organelle [inference]

protein localization to vacuole

protein localization to membrane [inference]

protein localization to membrane raft [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

protein localization to plasma membrane raft [inference]

protein transport into plasma membrane raft

protein localization to cell periphery [inference]

protein localization to plasma membrane raft [inference]

protein transport into plasma membrane raft

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport [inference]

renal sodium ion transport [inference]

renal sodium ion absorption

protein transport [inference]

intracellular protein transport [inference]

protein transport within lipid bilayer [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

organic anion transport [inference]

urate transport

carboxylic acid transport [inference]

tricarboxylic acid transport [inference]

citrate transport [inference]

citric acid secretion

organic acid transport [inference]

carboxylic acid transport [inference]

tricarboxylic acid transport [inference]

citrate transport [inference]

citric acid secretion

one-carbon compound transport [inference]

urea transport [inference]

urea transmembrane transport

secretion [inference]

acid secretion [inference]

citric acid secretion

intracellular transport [inference]

intracellular protein transport [inference]

protein transport within lipid bilayer [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

transmembrane transport [inference]

urea transmembrane transport

nitrogen compound transport [inference]

urate transport

urea transport [inference]

urea transmembrane transport

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport within lipid bilayer [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

establishment of protein localization to membrane [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport within lipid bilayer [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport within lipid bilayer [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to membrane raft [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

protein localization to plasma membrane raft [inference]

protein transport into plasma membrane raft

establishment of protein localization to membrane [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport

regulation of transport [inference]

regulation of protein transport

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

tumor necrosis factor-mediated signaling pathway

apoptotic signaling pathway

regulation of biological quality [inference]

regulation of blood pressure

regulation of body fluid levels [inference]

regulation of urine volume

multicellular organismal-level water homeostasis

renal water homeostasis

Displaying entries **1 - 5** of 28 in total

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GO Term	Evidence Code	Reference
spindle pole	ISS	GO_REF
spindle pole	ISO	GO_REF
spindle pole	IEA	GO_REF
obsolete extracellular space
endoplasmic reticulum	IDA	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

ciliary membrane

plasma membrane region [inference]

cell projection membrane [inference]

ciliary membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 3** entries
GO Term	Evidence Code	Reference
calcium ion binding	IEA	GO_REF
IgG binding	ISO	GO_REF
IgG binding	IEA	GO_REF

GO Hierarchy

molecular function

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

immunoglobulin binding [inference]

IgG binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGIPLTWMLLVMMVTSWFTLAEASNSTEARRCSECHNNATCTVDGVVTTCSCQTGFTGDGLVCEDMDECATPWTHNCSNSSCVNTPGSFKCSCQDGFRLTPELSCTDVDECSEQGLSNCHALATCVNTEGDYLCVCPEGFTGDGWYCECSPGSCEPGLDCLPQGPDGKLVCQDPCNTYETLTEYWRSTEYGVGYSCDAGLHGWYRFTGQGGVRMAETCVPVLRCNTAAPMWLNGSHPSSSEGIVSRTACAHWSDQCCRWSTEIQVKACPGGFYIYNLTAPPECNLAYCTDPSSVEGTCEECRVDEDCISDNGRWRCQCKQDSNITDVSQLEYRLECGANDIKMSLRKCQLQSLGFMNVFMYLNDRQCSGFSESDERDWMSIVTPARNGPCGTVLRRNETHATYSNTLYLANAIIIRDIIIRMNFECSYPLDMKVSLKTSLQPMVSALNISLGGTGKFTVRMALFQSPTYTQPHQGPSVMLSTEAFLYVGTMLDGGDLSRFVLLMTNCYATPSSNSTDPVKYFIIQDSCPRTEDTTIQVTENGESSQARFSVQMFRFAGNYDLVYLHCEVYLCDSTSEQCKPTCSGTRFRSGNFIDQTRVLNLGPITRQGVQASVSKAASSNLRLLSIWLLLFPSATLIFMVQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 10** entries
Position	Description	Source
25	N-linked (GlcNAc...) asparagine	UniProt
38	N-linked (GlcNAc...) asparagine	UniProt
76	N-linked (GlcNAc...) asparagine	UniProt
79	N-linked (GlcNAc...) asparagine	UniProt
233	N-linked (GlcNAc...) asparagine	GlycoProtDB UniProt
276	N-linked (GlcNAc...) asparagine	UniProt
323	N-linked (GlcNAc...) asparagine	GlycoProtDB UniProt
397	N-linked (GlcNAc...) asparagine	UniProt
448	N-linked (GlcNAc...) asparagine	GlycoProtDB UniProt
514	N-linked (GlcNAc...) asparagine	GlycoProtDB UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Asparagine N-linked glycosylation	Mus musculus

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:557	kidney disease	Alliance of Genome Resources
DOID:0060062	autosomal dominant tubulointerstitial kidney disease	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

Annotation

International Collaboration

Acknowledgements