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Disks large homolog 2

Summary

UniProt ID: Q91XM9
Gene Symbol: Dlg2 Dlgh2
Gene ID: 23859
Organism: Mus musculus (house mouse)

External Links

GlyGen: Q91XM9
O-GlcNAcAtlas: Q91XM9
Re-Glyco: Q91XM9

Annotation

Keyword: 3D-structure Alternative splicing Cell membrane Cell projection Palmitate Phosphoprotein Reference proteome Repeat SH3 domain Synapse

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	Reference
chemical synaptic transmission	IMP	PMID
chemical synaptic transmission	IBA	GO_REF
chemical synaptic transmission	IEA	GO_REF
nervous system development	IBA	GO_REF
sensory perception of pain	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde axonal protein transport

retrograde axonal transport [inference]

retrograde axonal protein transport

axo-dendritic protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

cell adhesion [inference]

cell-cell adhesion

establishment or maintenance of cell polarity [inference]

establishment or maintenance of bipolar cell polarity [inference]

establishment or maintenance of apical/basal cell polarity [inference]

establishment or maintenance of epithelial cell apical/basal polarity

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde axonal protein transport

retrograde axonal transport [inference]

retrograde axonal protein transport

axo-dendritic protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to potassium ion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

neuronal ion channel clustering

clustering of voltage-gated potassium channels

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of pain

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

response to stimulus [inference]

response to chemical [inference]

response to metal ion [inference]

response to potassium ion [inference]

cellular response to potassium ion

cellular response to metal ion [inference]

cellular response to potassium ion

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to potassium ion

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to potassium ion

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

microtubule-based protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

protein localization to organelle [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

protein localization to membrane [inference]

receptor clustering

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

protein localization to cell junction [inference]

protein localization to synapse

protein localization to postsynapse [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

protein localization to presynapse [inference]

anterograde axonal protein transport

protein localization to cell periphery [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

protein-containing complex localization [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

establishment of localization [inference]

transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

microtubule-based protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde axonal protein transport

retrograde axonal transport [inference]

retrograde axonal protein transport

axo-dendritic protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

microtubule-based transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde axonal protein transport

retrograde axonal transport [inference]

retrograde axonal protein transport

axo-dendritic protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

microtubule-based protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

microtubule-based protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde axonal protein transport

retrograde axonal transport [inference]

retrograde axonal protein transport

axo-dendritic protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde axonal protein transport

retrograde axonal transport [inference]

retrograde axonal protein transport

axo-dendritic protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

receptor localization to synapse

neurotransmitter receptor localization to postsynaptic specialization membrane

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of biological quality [inference]

regulation of postsynaptic membrane neurotransmitter receptor levels

neurotransmitter receptor localization to postsynaptic specialization membrane

Displaying entries **1 - 5** of 39 in total

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GO Term	Evidence Code	Reference
nucleus	IDA	PMID
cytoplasm	IDA	PMID
plasma membrane	ISO	GO_REF
plasma membrane	IDA	PMID
plasma membrane	IEA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated potassium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

cellular anatomical structure [inference]

cytoplasm

neuron projection cytoplasm [inference]

axon cytoplasm

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

plasma membrane region [inference]

basolateral plasma membrane

synaptic membrane [inference]

postsynaptic membrane

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction

synapse [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

dendrite

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

postsynaptic specialization [inference]

postsynaptic density

juxtaparanode region of axon

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
kinase binding	ISO	PMID
kinase binding	IEA	GO_REF GO_REF
protein kinase binding	IBA	GO_REF
protein phosphatase binding	ISO	GO_REF
PDZ domain binding	ISO	GO_REF

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of synapse [inference]

structural constituent of postsynapse [inference]

structural constituent of postsynaptic specialization [inference]

structural constituent of postsynaptic density

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

glutamate receptor binding [inference]

ionotropic glutamate receptor binding

enzyme binding [inference]

kinase binding

protein kinase binding

phosphatase binding [inference]

protein phosphatase binding

protein domain specific binding [inference]

PDZ domain binding

protein-containing complex binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MFFACYCALRTNVKKYRYQDEDGPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLGEDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSTPYPHYHLGLLPDSDMTSHSQHSTATRQPSVTLQRAISLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVTLDGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGTKTLRGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites