GlyCosmos Portal

Submissions

C-1-tetrahydrofolate synthase, cytoplasmic

Summary

UniProt ID: Q922D8
Gene Symbol: Mthfd1
Gene ID: 108156
Organism: Mus musculus (house mouse)

External Links

GlyGen: Q922D8
PubChem: Q922D8
RaftProt: Q922D8
Re-Glyco: Q922D8

Annotation

Keyword: ATP-binding Acetylation Cytoplasm Direct protein sequencing Histidine biosynthesis Hydrolase Ligase Methionine biosynthesis Multifunctional enzyme NADP One-carbon metabolism Oxidoreductase Phosphoprotein Purine biosynthesis Reference proteome

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

1

2

3

4

5

Next ›

Last »
GO Term	Evidence Code	Reference
neutrophil homeostasis	IMP	PMID
neural tube closure	IMP	PMID
neural tube closure	IEA	GO_REF
purine nucleotide biosynthetic process	ISO	GO_REF
purine nucleotide biosynthetic process	IMP	PMID

GO Hierarchy

biological process

immune system process [inference]

leukocyte homeostasis [inference]

neutrophil homeostasis

myeloid cell homeostasis [inference]

neutrophil homeostasis

cellular process [inference]

metabolic process [inference]

modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid-containing compound biosynthetic process [inference]

tetrahydrofolate biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

tetrahydrofolate metabolic process [inference]

10-formyltetrahydrofolate metabolic process [inference]

10-formyltetrahydrofolate biosynthetic process

tetrahydrofolate interconversion

tetrahydrofolate biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

folic acid metabolic process

modified amino acid biosynthetic process [inference]

folic acid-containing compound biosynthetic process [inference]

tetrahydrofolate biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

sulfur compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

L-methionine metabolic process

homocysteine metabolic process [inference]

transsulfuration

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

organophosphate biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

modified amino acid biosynthetic process [inference]

folic acid-containing compound biosynthetic process [inference]

tetrahydrofolate biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

pteridine-containing compound biosynthetic process [inference]

folic acid-containing compound biosynthetic process [inference]

tetrahydrofolate biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

organophosphate biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

carbohydrate derivative biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid-containing compound biosynthetic process [inference]

tetrahydrofolate biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

tetrahydrofolate metabolic process [inference]

10-formyltetrahydrofolate metabolic process [inference]

10-formyltetrahydrofolate biosynthetic process

tetrahydrofolate interconversion

tetrahydrofolate biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

folic acid metabolic process

pteridine-containing compound biosynthetic process [inference]

folic acid-containing compound biosynthetic process [inference]

tetrahydrofolate biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

amino acid metabolic process [inference]

proteinogenic amino acid metabolic process [inference]

non-proteinogenic amino acid metabolic process [inference]

homocysteine metabolic process [inference]

transsulfuration

alpha-amino acid metabolic process [inference]

homocysteine metabolic process [inference]

transsulfuration

L-amino acid metabolic process [inference]

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

L-methionine metabolic process

homocysteine metabolic process [inference]

transsulfuration

dicarboxylic acid metabolic process [inference]

10-formyltetrahydrofolate metabolic process [inference]

10-formyltetrahydrofolate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

folic acid metabolic process

carboxylic acid biosynthetic process [inference]

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

proteinogenic amino acid metabolic process [inference]

non-proteinogenic amino acid metabolic process [inference]

homocysteine metabolic process [inference]

transsulfuration

alpha-amino acid metabolic process [inference]

homocysteine metabolic process [inference]

transsulfuration

L-amino acid metabolic process [inference]

one-carbon metabolic process [inference]

tetrahydrofolate interconversion

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

carbohydrate derivative metabolic process [inference]

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

carbohydrate derivative biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

neutrophil homeostasis

myeloid cell homeostasis [inference]

neutrophil homeostasis

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

tube closure [inference]

neural tube closure

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

somite development

animal organ development [inference]

heart development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

neutrophil homeostasis

myeloid cell homeostasis [inference]

neutrophil homeostasis

Displaying **all 5** entries
GO Term	Evidence Code	Reference
mitochondrion	HDA	PMID PMID
cytosol	ISO	GO_REF
cytosol	IDA	PMID PMID
cytosol	IBA	GO_REF
cytosol	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 14 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	Reference
formate-tetrahydrofolate ligase activity	ISO	GO_REF
formate-tetrahydrofolate ligase activity	IDA	PMID
formate-tetrahydrofolate ligase activity	IMP	PMID PMID
formate-tetrahydrofolate ligase activity	IEA	GO_REF GO_REF GO_REF GO_REF GO_REF
methenyltetrahydrofolate cyclohydrolase activity	ISS	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the CH-NH group of donors [inference]

oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [inference]

methylenetetrahydrofolate dehydrogenase (NADP+) activity

hydrolase activity [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [inference]

cyclohydrolase activity [inference]

methenyltetrahydrofolate cyclohydrolase activity

ligase activity [inference]

ligase activity, forming carbon-nitrogen bonds [inference]

formate-tetrahydrofolate ligase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MAPAGILNGKLVSAQIRDRLKNQVTRMQEQVPGFTPGLAILQVGDRDDSNLYINVKLKAAEEIGIKATHIKLPRTSTESEVLKYVISLNEDASVHGFIVQLPLDSENSINTEAVINAIAPEKDVDGLTSVSAGKLARGDLNDCFIPCTPKGCLELIKEAGVQIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTANLDKEVNKGDILVVATGQPEMVKGEWIKPGAVVIDCGINYVPDDTKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAQRFLQKFKPGKWTIQYNKLNLKTPVPSDIAISRSCKPKLIGNLAREIGLLTEEVELYGETKAKVLLSALDRLKHQPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLRQNVFACVRQPSQGPTFGIKGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLVPSVNGIRKFSDIQIRRLRRLGIEKTDPTTLTDDEINRFARLDIDPETITWQRVLDTNDRFLRKITIGQSPTEKGHTRTAQFDISVASEIMAVLALTSSLEDMRERLGRMVVASSKKGEPISCEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVGPEGFVVTEAGFGADIGMEKFFNIKCRYSGLQPHVVVLVATVRALKMHGGGPTVTAGLPLPKAYTEEDLDLVEKGFSNLRKQIENARMFGVPVVVAVNVFKTDTDAELDLVSRLSREHGAFDAVKCTHWAEGGQGALALAQAVQRASQAPSSFQLLYDLKLSIEDKIRIIAQRIYGADDIELLPEAQNKAEIYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFVLPIRDIRASVGAGFLYPLVGTMSTMPGLPTRPCFYDIDLDPETEQVNGLF

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
380				GlyGen
712				GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Metabolism of folate and pterines	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements