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MIRAGE

Metalloreductase STEAP4

Summary

UniProt ID: Q923B6
Gene Symbol: Steap4 Tiarp
Gene ID: 117167
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0007168
Re-Glyco: Q923B6

Annotation

Keyword: Cell membrane Copper Endosome FAD Golgi apparatus Heme Iron transport NADP Oxidoreductase Reference proteome Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
copper ion import	IDA	PMID
copper ion import	IBA	GO_REF
copper ion import	IEA	GO_REF
iron import into cell	IDA	PMID
iron import into cell	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

iron ion transmembrane transport [inference]

iron ion import across cell outer membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis [inference]

iron import into cell

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis [inference]

iron import into cell

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis [inference]

iron import into cell

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis [inference]

iron import into cell

inorganic ion homeostasis [inference]

intracellular iron ion homeostasis [inference]

iron import into cell

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

copper ion transport [inference]

copper ion import

iron ion transport [inference]

iron import into cell

iron ion transmembrane transport [inference]

iron ion import across cell outer membrane

monoatomic cation transmembrane transport [inference]

iron ion transmembrane transport [inference]

iron ion import across cell outer membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

iron ion transmembrane transport [inference]

iron ion import across cell outer membrane

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

iron ion transmembrane transport [inference]

iron ion import across cell outer membrane

establishment of localization in cell [inference]

iron import into cell

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	Reference
Golgi membrane	ISO	GO_REF
Golgi membrane	IEA	GO_REF
nucleoplasm	ISO	GO_REF
endosome	IDA	PMID
endosome	IBA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

nucleoplasm

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

early endosome membrane

bounding membrane of organelle [inference]

Golgi membrane

endosome membrane [inference]

early endosome membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	Reference
cupric reductase (NADH) activity	IDA	PMID
cupric reductase (NADH) activity	IBA	GO_REF
cupric reductase (NADH) activity	IEA	GO_REF
electron transfer activity	ISO	GO_REF
electron transfer activity	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on metal ions [inference]

ferric-chelate reductase activity [inference]

ferric-chelate reductase (NADPH) activity

oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor [inference]

binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

cation binding [inference]

metal ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

tetrapyrrole binding [inference]

heme binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

electron transfer activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MEKAHADEFPLTTDSSEKQGVVCIFGTGDFGKSLGLKMLQCGYSIVFGSRNPQVSSLLPRGAEVLSYSEAASKSDIIILAMHREHYDSLTELVDYLKGKVLVDVSNNRKINQYPESNAEYLAQLEPGAHVVKAFNTISAWALQSGTLDASRQVFVCGNDSKAKQRVMDIARTLGLTPLDQGSLMAASEIENYPLQLFPMWRFPFYLSSVLCVFFFVYCAIREVIYPYVNGKTDATYRLAISIPNRVFPITALILLALVYLPGILAAILQLYRGTKYRRFPNWLDHWMLCRKQLGLVALGFAFLHVIYTLVIPIRYYVRWRLRNATITQALTNKDSPFITSYAWINDSYLALGILGFFLFLLLGITSLPSVSNMVNWREFRFVQSKLGYLTLVLCTAHTLVYGGKRFLSPSILRWSLPSAYILALVIPCAVLVLKCILIMPCIDKTLTRIRQGWERNSKYTQSALNGKSDI

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
323				GlycoProtDB

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Transferrin endocytosis and recycling	Mus musculus

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026