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Solute carrier family 12 member 6

Summary

UniProt ID: Q924N4
Gene Symbol: Slc12a6 Kcc3
Gene ID: 107723
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB

GPDB0007180

GlyConnect

Solute carrier family 12 member 6

GlyGen

Q924N4

The O-GlcNAc Database

Q924N4

RaftProt

Q924N4

Re-Glyco

Q924N4

Annotation

Keyword: Alternative promoter usage Cell membrane Chloride Direct protein sequencing Disulfide bond Glycoprotein Metal-binding Phosphoprotein Potassium transport Reference proteome Symport Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	Reference
monoatomic ion transport	ISO	GO_REF
ion transport	ISO	GO_REF
monoatomic ion transport	IEA	GO_REF
ion transport	IEA	GO_REF
cell volume homeostasis	ISO	GO_REF

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular response to salt stress [inference]

cellular hypotonic salinity response

cellular hypotonic response

cellular hypotonic salinity response

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular response to salt stress [inference]

cellular hypotonic salinity response

cellular hypotonic response

cellular hypotonic salinity response

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress [inference]

cellular response to salt stress [inference]

cellular hypotonic salinity response

cellular hypotonic response

cellular hypotonic salinity response

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis

homeostatic process [inference]

cellular homeostasis [inference]

cell volume homeostasis

intracellular chemical homeostasis [inference]

intracellular glucose homeostasis [inference]

cellular response to glucose stimulus

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis [inference]

intracellular glucose homeostasis [inference]

cellular response to glucose stimulus

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

potassium ion homeostasis

monoatomic anion homeostasis [inference]

chloride ion homeostasis

intracellular chemical homeostasis [inference]

intracellular glucose homeostasis [inference]

cellular response to glucose stimulus

inorganic ion homeostasis [inference]

response to stimulus [inference]

response to stress [inference]

response to osmotic stress [inference]

hypotonic response [inference]

hypotonic salinity response [inference]

cellular hypotonic salinity response

cellular hypotonic response

cellular hypotonic salinity response

response to salt stress [inference]

hypotonic salinity response [inference]

cellular hypotonic salinity response

cellular response to salt stress [inference]

cellular hypotonic salinity response

cellular response to osmotic stress [inference]

cellular response to salt stress [inference]

cellular hypotonic salinity response

cellular hypotonic response

cellular hypotonic salinity response

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular response to salt stress [inference]

cellular hypotonic salinity response

cellular hypotonic response

cellular hypotonic salinity response

response to abiotic stimulus [inference]

response to osmotic stress [inference]

hypotonic response [inference]

hypotonic salinity response [inference]

cellular hypotonic salinity response

cellular hypotonic response

cellular hypotonic salinity response

response to salt stress [inference]

hypotonic salinity response [inference]

cellular hypotonic salinity response

cellular response to salt stress [inference]

cellular hypotonic salinity response

cellular response to osmotic stress [inference]

cellular response to salt stress [inference]

cellular hypotonic salinity response

cellular hypotonic response

cellular hypotonic salinity response

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress [inference]

cellular response to salt stress [inference]

cellular hypotonic salinity response

cellular hypotonic response

cellular hypotonic salinity response

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular response to salt stress [inference]

cellular hypotonic salinity response

cellular hypotonic response

cellular hypotonic salinity response

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose [inference]

cellular response to glucose stimulus

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular response to salt stress [inference]

cellular hypotonic salinity response

cellular hypotonic response

cellular hypotonic salinity response

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular response to salt stress [inference]

cellular hypotonic salinity response

cellular hypotonic response

cellular hypotonic salinity response

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress [inference]

cellular response to salt stress [inference]

cellular hypotonic salinity response

cellular hypotonic response

cellular hypotonic salinity response

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import into cell [inference]

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
plasma membrane	ISO	GO_REF
plasma membrane	IDA	PMID
plasma membrane	IEA	GO_REF
basolateral plasma membrane	IDA	PMID PMID
basolateral plasma membrane	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

basolateral plasma membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
potassium ion transmembrane transporter activity	ISO	GO_REF
potassium:chloride symporter activity	ISS	GO_REF
potassium:chloride symporter activity	ISO	GO_REF
potassium:chloride symporter activity	IDA	PMID PMID
potassium:chloride symporter activity	IEA	GO_REF GO_REF

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

potassium:chloride symporter activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity

potassium:chloride symporter activity

monoatomic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

potassium:chloride symporter activity

monoatomic anion:monoatomic cation symporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

potassium:chloride symporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

potassium:chloride symporter activity

binding [inference]

protein binding [inference]

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MHPPEATTKMSSVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPMSELSGATTSLATVALDPSSDRTSNPQDVTEDPSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKSPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGILQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFRSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHLDICSKTKEVDNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVISIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGNLNHEYVLADITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGDALAAEQTIKHLMEAEKVKGFCQLVVAAKLKEGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNVSFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKVKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
55		29187734 35822049 40021952	G49108TO	The O-GlcNAc Database
379	N-linked (GlcNAc...) asparagine	30899004	G80920RR G64527OM	UniProt GlyGen GlyConnect
398	N-linked (GlcNAc...) asparagine	30899004	G80920RR G64527OM	GlycoProtDB UniProt GlyGen GlyConnect
411	N-linked (GlcNAc...) asparagine			UniProt GlyGen
417	N-linked (GlcNAc...) asparagine			UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Cation-coupled Chloride cotransporters	Mus musculus

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0090003	agenesis of the corpus callosum with peripheral neuropathy	Alliance of Genome Resources
DOID:2477	motor peripheral neuropathy	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements