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GlyTouCan
Glycan Structure Repository
GlyComb
Glycoconjugate Repository
GlycoPOST
Glycomics MS raw data Repository
UniCarb-DR
Glycomics MS Repository for glycan annotations from GlycoWorkbench
LM-GlycoRepo
Repository for lectin-assisted multimodality data
All Resources
Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / OrganismsTools
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GALAXY
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Guidelines
MIRAGE
Nicastrin
Summary
- UniProt ID
- Q92542
- Gene Symbol
-
- KIAA0253
- NCSTN
- UNQ1874/PRO4317
- Gene ID
- 23385
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cytoplasmic vesicle
- Disease variant
- Disulfide bond
- Glycoprotein
- Notch signaling pathway
- Reference proteome
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| plasma membrane |
| membrane |
| melanosome |
| Golgi membrane |
| early endosome |
| endoplasmic reticulum |
| endoplasmic reticulum membrane |
| Golgi apparatus |
| sarcolemma |
| lysosomal membrane |
| GO Term |
|---|
| amyloid precursor protein catabolic process |
| membrane protein ectodomain proteolysis |
| cerebellum development |
| membrane protein intracellular domain proteolysis |
| neuron apoptotic process |
| GO Term |
|---|
| growth factor receptor binding |
| protein-macromolecule adaptor activity |
| ATPase binding |
| aspartic endopeptidase activity, intramembrane cleaving |
Sequence
MATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGLAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPIFLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTFSINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVASFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVDSFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQPLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFVTDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQDLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLYEYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARIFLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 506 | N-linked (GlcNAc...) asparagine | |||
| 530 | N-linked (GlcNAc...) asparagine | |||
| 531 |
|
|
||
| 562 | N-linked (GlcNAc...) asparagine |
|
||
| 573 | N-linked (GlcNAc...) asparagine |
|
||
| 580 | N-linked (GlcNAc...) asparagine | |||
| 612 | N-linked (GlcNAc...) asparagine | |||
| 708 |
|
G70101JE
G80920RR
G14260UH
G62765YT
G64527OM
G05724UK
G31852PQ
G39188ZX
G41247ZX
G02815KT
G92275SC
G08290VR
G96326PH
G37692EO
G15664MX
G72747WU
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activated NOTCH1 Transmits Signal to the Nucleus | Homo sapiens |
| Amyloid fiber formation | Homo sapiens |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | Homo sapiens |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | Homo sapiens |
| Degradation of the extracellular matrix | Homo sapiens |
| EPH-ephrin mediated repulsion of cells | Homo sapiens |
| NOTCH2 Activation and Transmission of Signal to the Nucleus | Homo sapiens |
| NOTCH3 Activation and Transmission of Signal to the Nucleus | Homo sapiens |
| NOTCH4 Activation and Transmission of Signal to the Nucleus | Homo sapiens |
| NRIF signals cell death from the nucleus | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10652 | Alzheimer's disease | |
| DOID:2280 | hidradenitis suppurativa | |
| DOID:5419 | schizophrenia |
