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Endoplasmin

Summary

UniProt ID: Q95M18
Gene Symbol: GRP94 HSP90B1 HSPC4 TRA1
Gene ID: 282646
Organism: Bos taurus (domestic cattle)

External Links

PubChem: Q95M18
Re-Glyco: Q95M18

Annotation

Keyword: ATP-binding Acetylation Calcium Chaperone Disulfide bond Endoplasmic reticulum Glycoprotein Hydrolase Hydroxylation Phosphoprotein Reference proteome Sarcoplasmic reticulum Signal

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	Reference
response to hypoxia	ISS	GO_REF
response to hypoxia	IEA	GO_REF
protein folding	IEA	GO_REF GO_REF
positive regulation of Wnt signaling pathway	IEA	GO_REF
retrograde protein transport, ER to cytosol	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

protein folding

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein metabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

intercellular transport [inference]

endoplasmic reticulum to cytosol transport [inference]

retrograde protein transport, ER to cytosol

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

endoplasmic reticulum to cytosol transport [inference]

retrograde protein transport, ER to cytosol

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to ATP

cellular response to oxygen-containing compound [inference]

cellular response to ATP

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

actin filament bundle assembly [inference]

actin rod assembly

supramolecular fiber organization [inference]

actin filament organization [inference]

actin filament bundle organization [inference]

actin filament bundle assembly [inference]

actin rod assembly

response to stimulus [inference]

response to stress [inference]

response to hypoxia

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to chemical [inference]

ERAD pathway

response to organophosphorus [inference]

response to ATP [inference]

cellular response to ATP

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to ATP

cellular response to oxygen-containing compound [inference]

cellular response to ATP

response to nitrogen compound [inference]

response to purine-containing compound [inference]

response to ATP [inference]

cellular response to ATP

cellular response to nitrogen compound [inference]

cellular response to ATP

response to oxygen-containing compound [inference]

response to ATP [inference]

cellular response to ATP

cellular response to oxygen-containing compound [inference]

cellular response to ATP

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to ATP

cellular response to oxygen-containing compound [inference]

cellular response to ATP

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

establishment of localization [inference]

transport [inference]

intercellular transport [inference]

endoplasmic reticulum to cytosol transport [inference]

retrograde protein transport, ER to cytosol

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

endoplasmic reticulum to cytosol transport [inference]

retrograde protein transport, ER to cytosol

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

endoplasmic reticulum to cytosol transport [inference]

retrograde protein transport, ER to cytosol

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

endoplasmic reticulum to cytosol transport [inference]

retrograde protein transport, ER to cytosol

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	Reference
endoplasmic reticulum	ISS	GO_REF
endoplasmic reticulum	IBA	GO_REF
endoplasmic reticulum	IEA	GO_REF
endoplasmic reticulum membrane	IEA	GO_REF
cytosol	ISS	GO_REF

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical structure [inference]

cytosol

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

midbody

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen [inference]

sarcoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
RNA binding	ISS	GO_REF
RNA binding	IEA	GO_REF
protein phosphatase inhibitor activity	IEA	GO_REF
ATP binding	IBA	GO_REF
ATP binding	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

nucleic acid binding [inference]

RNA binding

protein binding [inference]

signaling receptor binding [inference]

lipoprotein particle receptor binding [inference]

low-density lipoprotein particle receptor binding

enzyme binding [inference]

phosphatase binding [inference]

protein phosphatase binding

unfolded protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein folding chaperone [inference]

ATP-dependent protein folding chaperone

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

phosphatase inhibitor activity [inference]

protein phosphatase inhibitor activity

phosphatase regulator activity [inference]

phosphatase inhibitor activity [inference]

protein phosphatase inhibitor activity

protein phosphatase regulator activity [inference]

protein phosphatase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

phosphatase inhibitor activity [inference]

protein phosphatase inhibitor activity

ATP-dependent activity [inference]

ATP-dependent protein folding chaperone

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALAGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPAEEEEAAKEDKEESDDEAAVEEEEDEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADEKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPSDMTSLDQYVERMKEKQDKIYFMAGASRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKSKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRVKEDEDDKTVSDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETTEDTAEDTEQDEEEEMDAGTDEEEQETAEKSTAEKDEL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	Source
62	N-linked (GlcNAc...) asparagine	UniProt
107	N-linked (GlcNAc...) asparagine	UniProt
217	N-linked (GlcNAc...) asparagine	UniProt
445	N-linked (GlcNAc...) asparagine	UniProt
481	N-linked (GlcNAc...) asparagine	UniProt
502	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Interleukin-4 and Interleukin-13 signaling	Bos taurus
Post-translational protein phosphorylation	Bos taurus
Regulation of IGF Activity by IGFBP	Bos taurus
Trafficking and processing of endosomal TLR	Bos taurus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements