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Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1

Summary

UniProt ID: Q96AA3
Gene Symbol: RFT1
Gene ID: 91869
Organism: Homo sapiens (human)

External Links

GlyGen: Q96AA3
PubChem: Q96AA3
Re-Glyco: Q96AA3

Annotation

Keyword: Congenital disorder of glycosylation Disease variant Endoplasmic reticulum Proteomics identification Reference proteome Sugar transport Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
protein N-linked glycosylation	IMP	PMID
dolichol-linked oligosaccharide biosynthetic process	IMP	PMID
dolichol-linked oligosaccharide biosynthetic process	IEA	GO_REF
glycolipid translocation	IDA	PMID
glycolipid translocation	IGI	PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

carbohydrate derivative biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

carbohydrate derivative biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

glycolipid translocation

localization [inference]

establishment of localization [inference]

transport [inference]

lipid transport [inference]

lipid translocation [inference]

glycolipid translocation

glycolipid transport [inference]

glycolipid translocation

carbohydrate derivative transport [inference]

glycolipid transport [inference]

glycolipid translocation

biological regulation [inference]

regulation of biological quality [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

glycolipid translocation

Displaying **all 5** entries
GO Term	Evidence Code	Reference
endoplasmic reticulum membrane	ISS	GO_REF
endoplasmic reticulum membrane	TAS	Reactome
endoplasmic reticulum membrane	IGI	PMID
endoplasmic reticulum membrane	IBA	GO_REF
endoplasmic reticulum membrane	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 2** entries
GO Term	Evidence Code	Reference
glycolipid floppase activity	TAS	Reactome
glycolipid floppase activity	IDA	PMID

GO Hierarchy

molecular function

transporter activity [inference]

intramembrane lipid carrier activity [inference]

ATPase-coupled intramembrane lipid carrier activity [inference]

floppase activity [inference]

glycolipid floppase activity

molecular carrier activity [inference]

lipid carrier activity [inference]

intramembrane lipid carrier activity [inference]

ATPase-coupled intramembrane lipid carrier activity [inference]

floppase activity [inference]

glycolipid floppase activity

ATP-dependent activity [inference]

ATPase-coupled intramembrane lipid carrier activity [inference]

floppase activity [inference]

glycolipid floppase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGSQEVLGHAARLASSGLLLQVLFRLITFVLNAFILRFLSKEIVGVVNVRLTLLYSTTLFLAREAFRRACLSGGTQRDWSQTLNLLWLTVPLGVFWSLFLGWIWLQLLEVPDPNVVPHYATGVVLFGLSAVVELLGEPFWVLAQAHMFVKLKVIAESLSVILKSVLTAFLVLWLPHWGLYIFSLAQLFYTTVLVLCYVIYFTKLLGSPESTKLQTLPVSRITDLLPNITRNGAFINWKEAKLTWSFFKQSFLKQILTEGERYVMTFLNVLNFGDQGVYDIVNNLGSLVARLIFQPIEESFYIFFAKVLERGKDATLQKQEDVAVAAAVLESLLKLALLAGLTITVFGFAYSQLALDIYGGTMLSSGSGPVLLRSYCLYVLLLAINGVTECFTFAAMSKEEVDRYNFVMLALSSSFLVLSYLLTRWCGSVGFILANCFNMGIRITQSLCFIHRYYRRSPHRPLAGLHLSPVLLGTFALSGGVTAVSEVFLCCEQGWPARLAHIAVGAFCLGATLGTAFLTETKLIHFLRTQLGVPRRTDKMT

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
227			G58087IP	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	Homo sapiens
Defective RFT1 causes CDG-1n	Homo sapiens

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080566	congenital disorder of glycosylation In	Glyco-Disease Genes Database Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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External Links

Annotation

International Collaboration

Acknowledgements