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Multiple epidermal growth factor-like domains protein 10

Summary

UniProt ID: Q96KG7
Gene Symbol: MEGF10 KIAA1780
Gene ID: 84466
Organism: Homo sapiens (human)

External Links

GlycoProtDB: GPDB0012492
GlyGen: Q96KG7
Re-Glyco: Q96KG7

Annotation

Keyword: Alternative splicing Cell adhesion Cell membrane Cell projection Disease variant Disulfide bond EGF-like domain Glycoprotein Myogenesis Phagocytosis Phosphoprotein Proteomics identification Reference proteome Repeat Signal Transmembrane helix Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	Reference
skeletal muscle satellite cell activation	ISS	GO_REF
skeletal muscle satellite cell activation	IEA	GO_REF
skeletal muscle satellite cell differentiation	IMP	PMID
skeletal muscle satellite cell differentiation	IEA	GO_REF GO_REF
skeletal muscle satellite cell proliferation	ISS	GO_REF

GO Hierarchy

biological process

cellular process [inference]

cell activation [inference]

skeletal muscle satellite cell activation

cell adhesion [inference]

cell-cell adhesion [inference]

homotypic cell-cell adhesion

cell recognition [inference]

phagocytosis, recognition [inference]

recognition of apoptotic cell

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

apoptotic process involved in development

cell population proliferation [inference]

muscle cell proliferation

striated muscle cell proliferation [inference]

skeletal muscle cell proliferation [inference]

skeletal muscle satellite cell proliferation

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis [inference]

apoptotic cell clearance

cellular developmental process [inference]

cell differentiation [inference]

skeletal muscle cell differentiation [inference]

skeletal muscle satellite cell differentiation

cell development [inference]

cell motility [inference]

cell migration [inference]

muscle cell migration [inference]

myoblast migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

membrane invagination [inference]

plasma membrane invagination [inference]

phagocytosis, engulfment [inference]

engulfment of apoptotic cell

multicellular organismal process [inference]

cell activation [inference]

skeletal muscle satellite cell activation

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

cellular developmental process [inference]

cell differentiation [inference]

skeletal muscle cell differentiation [inference]

skeletal muscle satellite cell differentiation

cell development [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis [inference]

apoptotic cell clearance

import into cell [inference]

endocytosis [inference]

phagocytosis [inference]

apoptotic cell clearance

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of myoblast proliferation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of muscle cell differentiation

regulation of muscle organ development [inference]

regulation of striated muscle tissue development [inference]

regulation of skeletal muscle tissue development

regulation of muscle tissue development [inference]

regulation of striated muscle tissue development [inference]

regulation of skeletal muscle tissue development

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of myoblast proliferation

regulation of myoblast proliferation [inference]

positive regulation of myoblast proliferation

regulation of cell differentiation [inference]

regulation of muscle cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of myoblast proliferation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion

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GO Term	Evidence Code	Reference
phagocytic cup	IDA	PMID
phagocytic cup	IBA	GO_REF
phagocytic cup	IEA	GO_REF GO_REF GO_REF
plasma membrane	IDA	PMID GO_REF
plasma membrane	IBA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

phagocytic cup

membrane [inference]

plasma membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
complement component C1q complex binding	IDA	PMID
scavenger receptor activity	IDA	PMID
scavenger receptor activity	IBA	GO_REF
Notch binding	IBA	GO_REF
Notch binding	IPI	PMID

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

opsonin binding [inference]

complement component C1q complex binding

complement binding [inference]

complement component C1q complex binding

signaling receptor binding [inference]

Notch binding

protein-containing complex binding [inference]

complement component C1q complex binding

cargo receptor activity [inference]

scavenger receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MVISLNSCLSFICLLLCHWIGTASPLNLEDPNVCSHWESYSVTVQESYPHPFDQIYYTSCTDILNWFKCTRHRVSYRTAYRHGEKTMYRRKSQCCPGFYESGEMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDECPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLNSLSRTSTALPADSYQIGAIAGIIILVLVVLFLLALFIIYRHKQKGKESSMPAVTYTPAMRVVNADYTISGTLPHSNGGNANSHYFTNPSYHTLTQCATSPHVNNRDRMTVTKSKNNQLFVNLKNVNPGKRGPVGDCTGTLPADWKHGGYLNELGAFGLDRSYMGKSLKDLGKNSEYNSSNCSLSSSENPYATIKDPPVLIPKSSECGYVEMKSPARRDSPYAEINNSTSANRNVYEVEPTVSVVQGVFSNNGRLSQDPYDLPKNSHIPCHYDLLPVRDSSSSPKQEDSGGSSSNSSSSSE

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	PubMed ID	Source
134	N-linked (GlcNAc...) asparagine		GlycoProtDB UniProt GlyGen
496	N-linked (GlcNAc...) asparagine		UniProt GlyGen
580		23090970 24190977	GlyGen
678		23090970 24190977	GlyGen
807		23090970 24190977	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111333	congenital myopathy 10A	Alliance of Genome Resources
DOID:0081345	congenital myopathy 10B	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements