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Heparan-sulfate 6-O-sulfotransferase 2

Summary

UniProt ID: Q96MM7
Gene Symbol: HS6ST2 PSEC0092
Gene ID: 90161
Organism: Homo sapiens (human)

External Links

GlycoProtDB: GPDB0012496
GlyGen: Q96MM7
The Human Metabolome Database: HMDBP03073
The O-GlcNAc Database: Q96MM7
O-GlcNAcAtlas: Q96MM7
Re-Glyco: Q96MM7

Annotation

Keyword: Alternative splicing Disease variant Glycoprotein Intellectual disability Proteomics identification Reference proteome Signal-anchor Transferase Transmembrane helix

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	Reference
heparan sulfate proteoglycan biosynthetic process	TAS	Reactome
heparan sulfate proteoglycan biosynthetic process	IBA	GO_REF
heparan sulfate proteoglycan biosynthetic process	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

heparan sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

heparan sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

heparan sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

heparan sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

heparan sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

heparan sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

heparan sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	Reference
Golgi membrane	TAS	Reactome

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 4** entries
GO Term	Evidence Code	Reference
heparan sulfate 6-sulfotransferase activity	EXP	PMID PMID
heparan sulfate 6-sulfotransferase activity	TAS	Reactome
heparan sulfate 6-sulfotransferase activity	IBA	GO_REF
heparan sulfate 6-sulfotransferase activity	IEA	GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring sulphur-containing groups [inference]

sulfotransferase activity [inference]

proteoglycan sulfotransferase activity [inference]

heparan sulfate sulfotransferase activity [inference]

heparan sulfate 6-sulfotransferase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MALPACAVREFEPPRQPERGAPVRTTCPRRHSRVEAELAASRPGSVAASVRAGPPRGVSHGFHTRPLLDKPRKASSSLAGAACAPLFALLSRGRRRRMHVLRRRWDLGSLCRALLTRGLAALGHSLKHVLGAIFSKIFGPMASVGNMDEKSNKLLLALVMLFLFAVIVLQYVCPGTECQLLRLQAFSSPVPDPYRSEDESSARFVPRYNFTRGDLLRKVDFDIKGDDLIVFLHIQKTGGTTFGRHLVRNIQLEQPCECRVGQKKCTCHRPGKRETWLFSRFSTGWSCGLHADWTELTSCVPSVVDGKRDARLRPSRNFHYITILRDPVSRYLSEWRHVQRGATWKASLHVCDGRPPTSEELPSCYTGDDWSGCPLKEFMDCPYNLANNRQVRMLSDLTLVGCYNLSVMPEKQRNKVLLESAKSNLKHMAFFGLTEFQRKTQYLFEKTFNMNFISPFTQYNTTRASSVEINEEIQKRIEGLNFLDMELYSYAKDLFLQRYQFMRQKEHQEARRKRQEQRKFLKGRLLQTHFQSQGQGQSQNPNQNQSQNPNPNANQNLTQNLMQNLTQSLSQKENRESPKQNSGKEQNDNTSNGTNDYIGSVEKWR

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 13 in total

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Position	Description	PubMed ID	GlyTouCan ID	Source
183		23584533	G57321FI	GlyGen
209	N-linked (GlcNAc...) asparagine		G80920RR	UniProt GlyGen
398		29237092 35254053	G49108TO	The O-GlcNAc Database
404	N-linked (GlcNAc...) asparagine		G62765YT	UniProt GlyGen
460	N-linked (GlcNAc...) asparagine		G11314AS	GlycoProtDB UniProt GlyGen
522		23584533	G57321FI	GlyGen
528		23584533	G57321FI	GlyGen
544	N-linked (GlcNAc...) asparagine			UniProt GlyGen
556	N-linked (GlcNAc...) asparagine			UniProt GlyGen
564	N-linked (GlcNAc...) asparagine			UniProt GlyGen