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Low-density lipoprotein receptor 2

Summary

UniProt ID

Q99088

Gene Symbol

ldlr-b
ldlr2

Gene ID

[373644]

Organism

Xenopus laevis (African clawed frog)

External Links

Re-Glyco: Q99088

Annotation

Keyword: Cholesterol metabolism Coated pit Disulfide bond EGF-like domain Endocytosis Glycoprotein LDL Lipid transport Receptor Reference proteome Repeat Signal Transmembrane helix

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	Reference
cholesterol metabolic process
cholesterol homeostasis	IBA	GO_REF
receptor-mediated endocytosis involved in cholesterol transport	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis involved in cholesterol transport

cellular localization [inference]

intracellular transport [inference]

receptor-mediated endocytosis involved in cholesterol transport

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis involved in cholesterol transport

intracellular transport [inference]

receptor-mediated endocytosis involved in cholesterol transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis involved in cholesterol transport

establishment of localization in cell [inference]

intracellular transport [inference]

receptor-mediated endocytosis involved in cholesterol transport

cellular localization [inference]

intracellular transport [inference]

receptor-mediated endocytosis involved in cholesterol transport

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
early endosome	IBA	GO_REF
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF
clathrin-coated pit	IEA	GO_REF
apical plasma membrane	IEA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-lipid complex [inference]

lipoprotein particle [inference]

plasma lipoprotein particle [inference]

low-density lipoprotein particle

signaling receptor complex

extracellular protein-containing complex [inference]

plasma lipoprotein particle [inference]

low-density lipoprotein particle

cellular anatomical structure [inference]

membrane [inference]

plasma membrane region [inference]

apical plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

Displaying **all 4** entries
GO Term	Evidence Code	Reference
low-density lipoprotein particle receptor activity	IBA	GO_REF
calcium ion binding	IEA	GO_REF
hormone binding	IEA	GO_REF
lipoprotein particle binding	IBA	GO_REF

GO Hierarchy

molecular function

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

hormone binding

protein-containing complex binding [inference]

protein-lipid complex binding [inference]

lipoprotein particle binding

cargo receptor activity [inference]

lipoprotein particle receptor activity [inference]

low-density lipoprotein particle receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MMKPAVSFPLLLLGLCHVSAFSGIGKCDRNEFQCGDGKCIPYKWICDGSAECKDGSDESSETCRALTCGADQFSCGGRLNRCIPMSWKCDGQTDCENGSDENDCTRKVCADDQFTCRSGKCISLDFVCDQDQDCDDGSDESYCPAPTCNPAMFQCKDKGICIPKLWACDGDRDCEDGSDEDHCEGREPIKTDKPCAPLEFHCGSGECIHMSWKCDAGYDCKHKSDDKDCVKPTCRPDQFQCNDGTCIHGSRQCDREYDCKDLSDEEGCVNVTKCQGPDVFKCRSGECITMDKVCHKKRDCRDWTDEPIKECGENECLRNNGGCSHICNDLKIGYECLCNEGYRLVDQKRCEDINECENPNTCTQICINLHGGYKCECREGYQMDPVTASCKSIGTVAYLFFTNRHEVRKMTLDRSEYTSFIPRLKNVVALDMEIASNKIYWSDLTQRKIYSASMDKADNTSHHETVISNQIQAPDGIAVDWIHGNIYWTDSKFSTISVANTEGSKRKTLFTDDLAKPRDIVVDPSQGFMYWTDWGLPAKIEKGGLNGVDRYPLVTDNIEWPNGITLDLISQRLYWVDSKLHSLSCIDITGENRRTVLSDETHLAHPFGLTIFEDLVFWTDIENEAIFSAKRLTGENIMKVAEHLLSPEDIVLYHNLRQPKAENWCESHHLGNGGCGYLCLPAPHVNARSPKFTCACPDGMHLGTDMRNCMKEPVTQEATTSTTTSAPVTTTSTARPSSRITTLAKIASTTSTLAPQRPKMVSTTVPPRRPTTNSPKTTLRMNTEKVPAHTTQEPMTHSQLARNKFAEAGVVESARSHPTALYIVLPILILCLVSFGGFLLWKNWRLKNTNSINFDNPVYQKTTEEDQVHICRSQDGYTYPSRQMVSLEDHIA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites