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Sodium-coupled neutral amino acid transporter 3

Summary

UniProt ID: Q99624
Gene Symbol: SLC38A3 G17 NAT1 SN1 SNAT3
Gene ID: 10991
Organism: Homo sapiens (human)

External Links

PubChem: Q99624
The Human Metabolome Database: HMDBP03036
Re-Glyco: Q99624

Annotation

Keyword: Amino-acid transport Antiport Cell membrane Disease variant Disulfide bond Epilepsy Glycoprotein Intellectual disability Proteomics identification Reference proteome Sodium transport Symport Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 29 in total

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GO Term	Evidence Code	Reference
amino acid transmembrane transport	IBA	GO_REF
amino acid transport	TAS	Reactome
asparagine transport	IDA	PMID
asparagine transport	IBA	GO_REF
asparagine transport	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to potassium ion starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to potassium ion starvation

transmembrane transport [inference]

amino acid transmembrane transport

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

asparagine transmembrane transport [inference]

L-asparagine import across plasma membrane

azole transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

carboxylic acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

asparagine transmembrane transport [inference]

L-asparagine import across plasma membrane

export from cell [inference]

secretion by cell [inference]

L-glutamine secretion

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

multi-multicellular organism process [inference]

female pregnancy

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular amino acid homeostasis

chemical homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular amino acid homeostasis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to potassium ion starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to potassium ion starvation

response to abiotic stimulus [inference]

response to pH [inference]

response to acidic pH

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to potassium ion starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to potassium ion starvation

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to potassium ion starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to potassium ion starvation

localization [inference]

establishment of localization [inference]

transport [inference]

amino acid transport

amino acid transmembrane transport

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

asparagine transmembrane transport [inference]

L-asparagine import across plasma membrane

basic amino acid transport [inference]

neutral amino acid transport [inference]

asparagine transport

L-asparagine import across plasma membrane

L-glutamine transport

alanine transport [inference]

L-alanine transport

L-amino acid transport [inference]

L-glutamine transport

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

vascular transport [inference]

transport across blood-brain barrier

organic cation transport [inference]

L-glutamine transport

alanine transport [inference]

L-alanine transport

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

organic anion transport [inference]

carboxylic acid transport [inference]

asparagine transport

L-asparagine import across plasma membrane

aromatic amino acid transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

L-histidine transport

L-amino acid transport [inference]

L-glutamine transport

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

alanine transport [inference]

L-alanine transport

carboxylic acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

asparagine transmembrane transport [inference]

L-asparagine import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

asparagine transport

L-asparagine import across plasma membrane

aromatic amino acid transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

L-histidine transport

L-amino acid transport [inference]

L-glutamine transport

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

alanine transport [inference]

L-alanine transport

carboxylic acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

asparagine transmembrane transport [inference]

L-asparagine import across plasma membrane

secretion [inference]

secretion by cell [inference]

L-glutamine secretion

transmembrane transport [inference]

amino acid transmembrane transport

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

asparagine transmembrane transport [inference]

L-asparagine import across plasma membrane

azole transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

carboxylic acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

asparagine transmembrane transport [inference]

L-asparagine import across plasma membrane

nitrogen compound transport [inference]

asparagine transport

L-asparagine import across plasma membrane

aromatic amino acid transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

L-histidine transport

L-amino acid transport [inference]

L-glutamine transport

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

alanine transport [inference]

L-alanine transport

azole transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

asparagine transmembrane transport [inference]

L-asparagine import across plasma membrane

import into cell [inference]

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

export from cell [inference]

secretion by cell [inference]

L-glutamine secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of organic acid transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of glutamine transport

regulation of glutamine transport [inference]

positive regulation of glutamine transport

positive regulation of transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of glutamine transport

positive regulation of amine transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of glutamine transport

regulation of amine transport [inference]

positive regulation of amine transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of glutamine transport

regulation of amino acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of glutamine transport

regulation of glutamine transport [inference]

positive regulation of glutamine transport

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of glutamine transport

positive regulation of amine transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of glutamine transport

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
plasma membrane	ISS	GO_REF
plasma membrane	TAS	Reactome
plasma membrane	IDA	GO_REF
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	Reference
L-histidine transmembrane transporter activity	IDA	PMID
L-histidine transmembrane transporter activity	IBA	GO_REF
L-histidine transmembrane transporter activity	IEA	GO_REF
neutral L-amino acid:sodium symporter activity	ISS	GO_REF
neutral L-amino acid:sodium symporter activity	IEA	GO_REF

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

azole:proton antiporter activity [inference]

L-histidine, sodium:proton antiporter activity

metal cation:proton antiporter activity [inference]

sodium:proton antiporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

neutral L-amino acid:sodium symporter activity

solute:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

neutral L-amino acid:sodium symporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

neutral L-amino acid:sodium symporter activity

sodium:proton antiporter activity [inference]

metal cation:monoatomic cation antiporter activity [inference]

metal cation:proton antiporter activity [inference]

sodium:proton antiporter activity [inference]

amino acid:monoatomic cation antiporter activity [inference]

amino acid transmembrane transporter activity

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

neutral L-amino acid:sodium symporter activity

basic amino acid transmembrane transporter activity [inference]

L-histidine transmembrane transporter activity

L-histidine, sodium:proton antiporter activity

neutral L-amino acid transmembrane transporter activity [inference]

neutral L-amino acid:sodium symporter activity

L-asparagine transmembrane transporter activity

L-asparagine, sodium:proton antiporter activity

L-glutamine transmembrane transporter activity

L-glutamine, sodium:proton antiporter activity

alanine transmembrane transporter activity [inference]

L-alanine transmembrane transporter activity

L-amino acid transmembrane transporter activity [inference]

L-histidine transmembrane transporter activity

L-histidine, sodium:proton antiporter activity

L-alanine transmembrane transporter activity

L-asparagine transmembrane transporter activity

L-asparagine, sodium:proton antiporter activity

L-glutamine transmembrane transporter activity

L-glutamine, sodium:proton antiporter activity

amino acid:monoatomic cation antiporter activity [inference]

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

neutral L-amino acid:sodium symporter activity

solute:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

neutral L-amino acid:sodium symporter activity

antiporter activity [inference]

azole:proton antiporter activity [inference]

L-histidine, sodium:proton antiporter activity

metal cation:monoatomic cation antiporter activity [inference]

metal cation:proton antiporter activity [inference]

sodium:proton antiporter activity [inference]

amino acid:monoatomic cation antiporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

aromatic amino acid transmembrane transporter activity [inference]

L-histidine transmembrane transporter activity

L-histidine, sodium:proton antiporter activity

L-amino acid transmembrane transporter activity [inference]

L-histidine transmembrane transporter activity

L-histidine, sodium:proton antiporter activity

L-alanine transmembrane transporter activity

L-asparagine transmembrane transporter activity

L-asparagine, sodium:proton antiporter activity

L-glutamine transmembrane transporter activity

L-glutamine, sodium:proton antiporter activity

alanine transmembrane transporter activity [inference]

L-alanine transmembrane transporter activity

azole transmembrane transporter activity [inference]

L-histidine transmembrane transporter activity

L-histidine, sodium:proton antiporter activity

azole:proton antiporter activity [inference]

L-histidine, sodium:proton antiporter activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MEAPLQTEMVELVPNGKHSEGLLPVITPMAGNQRVEDPARSCMEGKSFLQKSPSKEPHFTDFEGKTSFGMSVFNLSNAIMGSGILGLAYAMANTGIILFLFLLTAVALLSSYSIHLLLKSSGVVGIRAYEQLGYRAFGTPGKLAAALAITLQNIGAMSSYLYIIKSELPLVIQTFLNLEEKTSDWYMNGNYLVILVSVTIILPLALMRQLGYLGYSSGFSLSCMVFFLIAVIYKKFHVPCPLPPNFNNTTGNFSHVEIVKEKVQLQVEPEASAFCTPSYFTLNSQTAYTIPIMAFAFVCHPEVLPIYTELKDPSKKKMQHISNLSIAVMYIMYFLAALFGYLTFYNGVESELLHTYSKVDPFDVLILCVRVAVLTAVTLTVPIVLFPVRRAIQQMLFPNQEFSWLRHVLIAVGLLTCINLLVIFAPNILGIFGVIGATSAPFLIFIFPAIFYFRIMPTEKEPARSTPKILALCFAMLGFLLMTMSLSFIIIDWASGTSRHGGNH

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	Source
74	N-linked (GlcNAc...) asparagine	UniProt
247	N-linked (GlcNAc...) asparagine	UniProt
248	N-linked (GlcNAc...) asparagine	UniProt
252	N-linked (GlcNAc...) asparagine	UniProt
323	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Amino acid transport across the plasma membrane	Homo sapiens

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070388	developmental and epileptic encephalopathy 102	Alliance of Genome Resources

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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Acknowledgements