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MIRAGE

Ubiquitin carboxyl-terminal hydrolase 26

Summary

UniProt ID: Q99MX1
Gene Symbol: Usp26
Gene ID: 83563
Organism: Mus musculus (house mouse)

External Links

GlyGen: Q99MX1
The O-GlcNAc Database: Q99MX1
O-GlcNAcAtlas: Q99MX1
Re-Glyco: Q99MX1

Annotation

Keyword: Cytoskeleton Flagellum Nucleus Reference proteome Thiol protease Ubl conjugation pathway

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
G1/S transition of mitotic cell cycle	IBA	GO_REF
proteolysis
spermatogenesis	ISS	GO_REF
spermatogenesis	ISO	GO_REF
protein deubiquitination	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

cell cycle process [inference]

cell cycle phase transition [inference]

mitotic cell cycle phase transition [inference]

G1/S transition of mitotic cell cycle

cell cycle G1/S phase transition [inference]

G1/S transition of mitotic cell cycle

mitotic cell cycle process [inference]

mitotic cell cycle phase transition [inference]

G1/S transition of mitotic cell cycle

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of intracellular steroid hormone receptor signaling pathway [inference]

regulation of androgen receptor signaling pathway

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of intracellular steroid hormone receptor signaling pathway [inference]

regulation of androgen receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of intracellular steroid hormone receptor signaling pathway [inference]

regulation of androgen receptor signaling pathway

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of biological quality [inference]

regulation of protein stability

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
nucleus	ISS	GO_REF
nucleus	ISO	GO_REF
nucleus	IEA	GO_REF
nucleoplasm	ISO	GO_REF
cytosol	ISO	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

motile cilium [inference]

9+2 motile cilium [inference]

sperm flagellum

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

motile cilium [inference]

9+2 motile cilium [inference]

sperm flagellum

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
cysteine-type deubiquitinase activity	ISS	GO_REF
cysteine-type deubiquitinase activity	ISO	GO_REF
cysteine-type deubiquitinase activity	IEA	GO_REF GO_REF
deubiquitinase activity	ISO	GO_REF
K48-linked deubiquitinase activity	ISS	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

cysteine-type peptidase activity [inference]

cysteine-type deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

cysteine-type peptidase activity [inference]

cysteine-type deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MEPILINAQVQMWSAKAGMSKSRNALIETCVGKREVKLILYFSTGKIKTLQLHDNIKSVVLQTYGEDQNYLHLTFKNNDFLFVEKLTTTDARRLKRFLDKTSQGSIRPARSDERCGEPSTSAQELNGSGSSCETNSECFESPKESEMCMFRELSLLPSSSTFLHNVGLLENQFIKRKRFFSDLAKNEKQSNLKDSIRDFEANLVVCISNEKGKERNVREVDISKPGFGFPFETNYPEDSGVDVRDLNDLITKLFSPVLLETHCIENGLEWHEYMKTYLLYPEKLWQGLPNVGNTCYINVVLQSLCSIPLFINDLFNQGFPWIKAPKDDFNMLLMQLLVLKDIYNARFRQKLLIGITKALPIFGEIFAVDRQNDAHEFLSLCLVQLKETFQRVTMMWQSENDSGDFYLLKDIFADYATINKMPVCPVTNNFEFELLSSIFCKACGLTLFKGEPSRYLSINIPQGGKDMSIQSTLDLFFSAEELEHRCEKCLYNKSVSFHRFGRLPRVIIVHLKRYHFNESWVMKKDERPILVSKYLRLSCHCSKSTKPPPPLRPGEHVKNLDLLKPLEVLGSEILKLPFNSVRTSRSKGFETINITSNRESEAQSGKRVSEVLSGKVQQENSGKGDTAHIVGSELTKETEKLKKHEEEHRPSDLDSGSIREAQKYQQAEKCNEGRSDKQISLEALTQSRPKPISQEQTENLGKTTLSHTQDSSQSSQSSSDSSKSSRCSDDLDKKAKPTRKVDPTKLNKKEDNVYRLVNIINHIGNSPNGGHYINDAFDFKRQSWFTYSDLHVTRTQEDFVYRGRSSTGYVFFYMHNDIFEELLAKETQSTSTSKG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
400			G41247ZX	GlyGen
446		30016717	G49108TO	GlyGen The O-GlcNAc Database
517			G31852PQ	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Ub-specific processing proteases	Mus musculus

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026