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Sodium-dependent lysophosphatidylcholine symporter 1

Summary

UniProt ID: Q9DA75
Gene Symbol: Mfsd2a Mfsd2 Nls1
Gene ID: 76574
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB

GPDB0007432

PubChem

Q9DA75

SwissLipids

SLP:000000999

Re-Glyco

Q9DA75

Annotation

Keyword: 3D-structure Cell membrane Disulfide bond Endoplasmic reticulum Glycoprotein Lipid transport Reference proteome Symport Transmembrane helix

Gene Ontology (GO)

Displaying entries **11 - 15** of 45 in total

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GO Term	Evidence Code	Reference
fatty acid transport	IBA	GO_REF
fatty acid transport	IEA	GO_REF
long-chain fatty acid transport	IMP	PMID
hippocampus development	IDA	PMID
positive regulation of cell growth	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

transcytosis

cellular developmental process [inference]

cell development [inference]

establishment of blood-brain barrier

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

very-low-density lipoprotein particle assembly

photoreceptor cell outer segment organization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

very-low-density lipoprotein particle assembly

protein-lipid complex organization [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

very-low-density lipoprotein particle assembly

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle assembly [inference]

very-low-density lipoprotein particle assembly

membrane organization [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation [inference]

lysophospholipid translocation

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier [inference]

lipid transport across blood-brain barrier

nervous system process [inference]

cognition

behavior [inference]

motor behavior

transcytosis

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

maintenance of blood-brain barrier

energy homeostasis

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle assembly [inference]

very-low-density lipoprotein particle assembly

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis [inference]

cell morphogenesis involved in neuron differentiation [inference]

photoreceptor cell morphogenesis

retina morphogenesis in camera-type eye

anatomical structure development [inference]

cell development [inference]

establishment of blood-brain barrier

animal gross anatomical part developmental process [inference]

tissue development [inference]

epithelium development [inference]

retinal pigment epithelium development

hippocampus development

animal organ development [inference]

brain development

cellular developmental process [inference]

cell development [inference]

establishment of blood-brain barrier

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

maintenance of blood-brain barrier

energy homeostasis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

localization [inference]

establishment of localization [inference]

transport [inference]

lipid transport [inference]

fatty acid transport

long-chain fatty acid transport

phospholipid transport [inference]

phospholipid translocation [inference]

lysophospholipid translocation

lysophospholipid transport

lysophospholipid translocation

lipid translocation [inference]

phospholipid translocation [inference]

lysophospholipid translocation

lipid transport across blood-brain barrier

carbohydrate transport

vascular transport [inference]

transport across blood-brain barrier [inference]

lipid transport across blood-brain barrier

organophosphate ester transport [inference]

phospholipid transport [inference]

phospholipid translocation [inference]

lysophospholipid translocation

lysophospholipid transport

lysophospholipid translocation

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport

long-chain fatty acid transport

vesicle-mediated transport [inference]

transcytosis

transmembrane transport

carbohydrate derivative transport [inference]

lysophospholipid transport

lysophospholipid translocation

biological regulation [inference]

regulation of biological process [inference]

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth

positive regulation of growth [inference]

positive regulation of cell growth

regulation of developmental growth [inference]

regulation of multicellular organism growth

positive regulation of biological process [inference]

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of cell growth

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of lipid catabolic process [inference]

negative regulation of fatty acid beta-oxidation

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid oxidation [inference]

negative regulation of fatty acid beta-oxidation

negative regulation of lipid catabolic process [inference]

negative regulation of fatty acid beta-oxidation

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid oxidation [inference]

negative regulation of fatty acid beta-oxidation

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of neuron projection arborization

regulation of developmental growth [inference]

regulation of multicellular organism growth

regulation of dendrite development

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of triglyceride biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of lipid catabolic process [inference]

negative regulation of fatty acid beta-oxidation

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid oxidation [inference]

negative regulation of fatty acid beta-oxidation

negative regulation of lipid catabolic process [inference]

negative regulation of fatty acid beta-oxidation

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid oxidation [inference]

negative regulation of fatty acid beta-oxidation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of lipid catabolic process [inference]

negative regulation of fatty acid beta-oxidation

regulation of lipid catabolic process [inference]

regulation of fatty acid beta-oxidation [inference]

negative regulation of fatty acid beta-oxidation

negative regulation of lipid catabolic process [inference]

negative regulation of fatty acid beta-oxidation

regulation of ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid oxidation [inference]

negative regulation of fatty acid beta-oxidation

regulation of fatty acid oxidation [inference]

regulation of fatty acid beta-oxidation [inference]

negative regulation of fatty acid beta-oxidation

negative regulation of fatty acid oxidation [inference]

negative regulation of fatty acid beta-oxidation

regulation of phosphorus metabolic process [inference]

regulation of phospholipid metabolic process [inference]

regulation of small molecule metabolic process [inference]

regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid oxidation [inference]

negative regulation of fatty acid beta-oxidation

regulation of fatty acid oxidation [inference]

regulation of fatty acid beta-oxidation [inference]

negative regulation of fatty acid beta-oxidation

negative regulation of fatty acid oxidation [inference]

negative regulation of fatty acid beta-oxidation

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid oxidation [inference]

negative regulation of fatty acid beta-oxidation

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid oxidation [inference]

negative regulation of fatty acid beta-oxidation

regulation of fatty acid oxidation [inference]

regulation of fatty acid beta-oxidation [inference]

negative regulation of fatty acid beta-oxidation

negative regulation of fatty acid oxidation [inference]

negative regulation of fatty acid beta-oxidation

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid oxidation [inference]

negative regulation of fatty acid beta-oxidation

negative regulation of lipid catabolic process [inference]

negative regulation of fatty acid beta-oxidation

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of triglyceride biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of lipid catabolic process [inference]

regulation of fatty acid beta-oxidation [inference]

negative regulation of fatty acid beta-oxidation

negative regulation of lipid catabolic process [inference]

negative regulation of fatty acid beta-oxidation

regulation of triglyceride metabolic process [inference]

regulation of triglyceride biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of phospholipid metabolic process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of cell growth

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of lipid catabolic process [inference]

negative regulation of fatty acid beta-oxidation

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid oxidation [inference]

negative regulation of fatty acid beta-oxidation

negative regulation of lipid catabolic process [inference]

negative regulation of fatty acid beta-oxidation

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid oxidation [inference]

negative regulation of fatty acid beta-oxidation

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of dendrite development

regulation of neuron projection arborization

regulation of multicellular organismal process [inference]

regulation of multicellular organism growth

regulation of biological quality [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation [inference]

lysophospholipid translocation

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
endoplasmic reticulum membrane	EXP	PMID
endoplasmic reticulum membrane	IEA	GO_REF
cytosol	ISO	GO_REF
plasma membrane	ISO	GO_REF
plasma membrane	IDA	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

intracellular organelle [inference]

intracellular membraneless organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	Reference
long-chain fatty acid transmembrane transporter activity	ISO	GO_REF
long-chain fatty acid transmembrane transporter activity	IMP	PMID PMID
long-chain fatty acid transmembrane transporter activity	IEA	GO_REF GO_REF
fatty acid transmembrane transporter activity	IDA	PMID
fatty acid transmembrane transporter activity	IBA	GO_REF

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

lysophospholipid:sodium symporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

lysophospholipid:sodium symporter activity

organophosphate ester transmembrane transporter activity [inference]

lysophospholipid:sodium symporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

lysophospholipid:sodium symporter activity

carboxylic acid transmembrane transporter activity [inference]

monocarboxylic acid transmembrane transporter activity [inference]

fatty acid transmembrane transporter activity

long-chain fatty acid transmembrane transporter activity

oleate transmembrane transporter activity

lipid transmembrane transporter activity [inference]

fatty acid transmembrane transporter activity

long-chain fatty acid transmembrane transporter activity

oleate transmembrane transporter activity

lysophospholipid:sodium symporter activity

carbohydrate derivative transmembrane transporter activity [inference]

lysophospholipid:sodium symporter activity

intramembrane lipid carrier activity [inference]

ATPase-coupled intramembrane lipid carrier activity [inference]

flippase activity [inference]

glycerophospholipid flippase activity [inference]

lysophosphatidylcholine flippase activity

molecular carrier activity [inference]

lipid carrier activity [inference]

intramembrane lipid carrier activity [inference]

ATPase-coupled intramembrane lipid carrier activity [inference]

flippase activity [inference]

glycerophospholipid flippase activity [inference]

lysophosphatidylcholine flippase activity

ATP-dependent activity [inference]

ATPase-coupled intramembrane lipid carrier activity [inference]

flippase activity [inference]

glycerophospholipid flippase activity [inference]

lysophosphatidylcholine flippase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MAKGEGAESGSAAGLLPTSILQASERPVQVKKEPKKKQQLSICNKLCYAVGGAPYQLTGCALGFFLQIYLLDVAKVEPLPASIILFVGRAWDAFTDPLVGFCISKSSWTRLGRLMPWIIFSTPLAIIAYFLIWFVPDFPSGTESSHGFLWYLLFYCLFETLVTCFHVPYSALTMFISTEQSERDSATAYRMTVEVLGTVIGTAIQGQIVGQAKAPCLQDQNGSVVVSEVANRTQSTASLKDTQNAYLLAAGIIASIYVLCAFILILGVREQRELYESQQAESMPFFQGLRLVMGHGPYVKLIAGFLFTSLAFMLVEGNFALFCTYTLDFRNEFQNLLLAIMLSATFTIPIWQWFLTRFGKKTAVYIGISSAVPFLILVALMERNLIVTYVVAVAAGVSVAAAFLLPWSMLPDVIDDFHLKHPHSPGTEPIFFSFYVFFTKFASGVSLGVSTLSLDFANYQRQGCSQPEQVKFTLKMLVTMAPIILILLGLLLFKLYPIDEEKRRQNKKALQALREEASSSGCSDTDSTELASIL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
221	N-linked (GlcNAc...) asparagine			GlycoProtDB UniProt
231	N-linked (GlcNAc...) asparagine			GlycoProtDB UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Synthesis of PC	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements