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Platelet-derived growth factor receptor alpha

Summary

UniProt ID: Q9DE49
Gene Symbol: pdgfra
Gene ID: 386856
Organism: Danio rerio (zebrafish)

External Links

PubChem: Q9DE49
Re-Glyco: Q9DE49

Annotation

Keyword: ATP-binding Cell membrane Cell projection Chemotaxis Developmental protein Disulfide bond Glycoprotein Golgi apparatus Immunoglobulin domain Phosphoprotein Receptor Reference proteome Repeat Transmembrane helix Tyrosine-protein kinase Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	Reference
neural crest cell migration	IMP	PMID
neural crest cell migration	IGI	PMID
cardiac muscle progenitor cell migration to the midline involved in heart field formation	IMP	PMID
cardioblast cell midline fusion	IMP	PMID
chemotaxis

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell adhesion involved in heart morphogenesis [inference]

cardioblast cell midline fusion

cell-cell adhesion [inference]

homotypic cell-cell adhesion [inference]

cardioblast cell midline fusion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway

cell motility [inference]

cell migration

ameboidal-type cell migration [inference]

mesenchymal cell migration [inference]

neural crest cell migration

cell migration involved in heart development [inference]

cell migration to the midline involved in heart development [inference]

cardioblast migration to the midline involved in heart field formation [inference]

cardiac muscle progenitor cell migration to the midline involved in heart field formation

cell migration involved in heart formation [inference]

cardioblast migration [inference]

cardioblast migration to the midline involved in heart field formation [inference]

cardiac muscle progenitor cell migration to the midline involved in heart field formation

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

embryonic organ morphogenesis [inference]

embryonic skeletal system morphogenesis [inference]

embryonic cranial skeleton morphogenesis

skeletal system morphogenesis [inference]

embryonic skeletal system morphogenesis [inference]

embryonic cranial skeleton morphogenesis

embryonic morphogenesis [inference]

embryonic organ morphogenesis [inference]

embryonic skeletal system morphogenesis [inference]

embryonic cranial skeleton morphogenesis

embryonic neurocranium morphogenesis

anatomical structure development [inference]

animal organ development [inference]

heart development

system development [inference]

vasculature development [inference]

cerebellum vasculature development

roof of mouth development

locomotion [inference]

taxis [inference]

chemotaxis

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of hematopoietic progenitor cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of cell differentiation [inference]

regulation of hematopoietic progenitor cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
Golgi apparatus	ISS	GO_REF
Golgi apparatus	IEA	GO_REF
plasma membrane	ISS	GO_REF
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 4** entries
GO Term	Evidence Code	Reference
platelet-derived growth factor alpha-receptor activity	IBA	GO_REF
platelet-derived growth factor alpha-receptor activity	IEA	GO_REF
ATP binding	IEA	GO_REF
platelet-derived growth factor binding	IBA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

platelet-derived growth factor receptor activity [inference]

platelet-derived growth factor alpha-receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

platelet-derived growth factor receptor activity [inference]

platelet-derived growth factor alpha-receptor activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

platelet-derived growth factor receptor activity [inference]

platelet-derived growth factor alpha-receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

platelet-derived growth factor receptor activity [inference]

platelet-derived growth factor alpha-receptor activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

platelet-derived growth factor receptor activity [inference]

platelet-derived growth factor alpha-receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

platelet-derived growth factor receptor activity [inference]

platelet-derived growth factor alpha-receptor activity

binding [inference]

protein binding [inference]

growth factor binding [inference]

platelet-derived growth factor binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

platelet-derived growth factor receptor activity [inference]

platelet-derived growth factor alpha-receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MFPVLPQSVQAPLIWPQRESMEVSLHSTFRLTCRGQTELSWNGPVFIDDQTNSVKKGLFISTVTISNATAVHTGEYVCSSEPFNSTESTIYIYVPDPQTPFVPSMTPFENHVLTSYDEMEIPCRVTDPSASVSLIHMGTDQVMPSAYDSKRGFIGLFGAGTYVCRALIHGQNHDSIEYIVHGWTGGSDLRVELRAVKRTLLVGETITVDCVAKGSEVLEDHWKYPGKLANRGPKTVKENKLNLEIYYTLTVTNASPKDSGIYACSITDIMSNESQTKELTITVYDHEFVHINPLIGPVETARLDEVPEFKVDIESFPAPKVTWLKDSSVLGDDTAEISTTLLKIGETSYQGVLNLIRAKAEDSGNYTVKAEIGSISTSYSFYLQVKVPPVIVDLIDVHHGSAAGQEVVCTAGGSPFPEVDWDICKNLKHCANDSSQWMPLPINSTDITVELQMNVDNHIESHIIFHHLEGTVAVRCLARNDMGVVSREVKLMSSGPHSELTVAAAVLVLLVIVIISLIVLVIIWKQKPRYEIRWRVIESVSPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDGFLSRHTEKGKKDLDIFGINPADESSRSYVILSLEGKGDYMDMKQADTMQYVPMLEMNEASKYSPIQRSDYDHPPSHRQFNDEAESLLSDDSAEGLTTMDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLSQGKIVKICDFGLARDIMHDNNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMVVDSSFYNKIKSGYRMTKPEHASSDVYELMMKCWNSEPEKRPSFHSLSDTVASLLPSGFKRCYERVNHDFLKSDHPAVTRVQCIDNDDAYMGVLYKNQGKMKTRESGFDEQRLSSDSGYIIPLPDLDPLSNEDYSKRNRHSSQTSEESAIDTGSSSSTTKREGETLEDITLLDEMCLDSGDLVEDSFL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	Source
67	N-linked (GlcNAc...) asparagine	UniProt
84	N-linked (GlcNAc...) asparagine	UniProt
272	N-linked (GlcNAc...) asparagine	UniProt
365	N-linked (GlcNAc...) asparagine	UniProt
432	N-linked (GlcNAc...) asparagine	UniProt
443	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
Downstream signal transduction	Danio rerio
PI3K/AKT Signaling	Danio rerio
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Danio rerio
RAF/MAP kinase cascade	Danio rerio
Signaling by PDGF	Danio rerio

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

Annotation

International Collaboration

Acknowledgements