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NPC intracellular cholesterol transporter 2

Summary

UniProt ID: Q9DGJ3
Gene Symbol: npc2
Gene ID: 282673
Organism: Danio rerio (zebrafish)

External Links

Re-Glyco: Q9DGJ3

Annotation

Keyword: Cholesterol metabolism Disulfide bond Endoplasmic reticulum Glycoprotein Lipid transport Lysosome Reference proteome Secreted Signal

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
inflammatory response	IMP	PMID
central nervous system development	IMP	PMID
blood circulation	IMP	PMID
cholesterol metabolic process
intracellular cholesterol transport	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

ensheathment of neurons [inference]

axon ensheathment [inference]

myelination

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

cellular localization [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

blood circulation

behavior [inference]

motor behavior

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

embryonic organ morphogenesis [inference]

notochord morphogenesis

embryonic morphogenesis [inference]

embryonic organ morphogenesis [inference]

notochord morphogenesis

anatomical structure formation involved in morphogenesis [inference]

otolith formation

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

otic vesicle development

tube development [inference]

otic vesicle development

animal organ development [inference]

sensory organ development [inference]

otic vesicle development

system development [inference]

central nervous system development

inner ear development [inference]

otic vesicle development

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

localization [inference]

establishment of localization [inference]

transport [inference]

lipid transport [inference]

sterol transport [inference]

cholesterol transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

intracellular transport [inference]

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

cellular localization [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
extracellular region	ISS	GO_REF
extracellular region	IEA	GO_REF
lysosome	ISS	GO_REF
lysosome	IEA	GO_REF
endoplasmic reticulum	ISS	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

Displaying 1 entry
GO Term	Evidence Code	Reference
cholesterol binding	IBA	GO_REF

GO Hierarchy

molecular function

binding [inference]

lipid binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

small molecule binding [inference]

alcohol binding [inference]

cholesterol binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MDYRVLGVVLLSFLAYTCADPVKFVDCGSVDGKVVQVDIKPCSQQPCKLHKGQSYTVNVTFSSGVESQTSKAVVHGVLAGVPVPFPIPIDDGCKSGIQCPIVPQKPYNYVTELPVKTEYPAIKVVVEWELRDDSSKDLFCIKFPVQIVN

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
58	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
LDL clearance	Danio rerio
Neutrophil degranulation	Danio rerio

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

Annotation

International Collaboration

Acknowledgements