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Tripeptidyl-peptidase 1

Summary

UniProt ID: Q9EQV6
Gene Symbol: Tpp1 Cln2
Gene ID: 83534
Organism: Rattus norvegicus (Norway rat)

External Links

GlyGen: Q9EQV6
PubChem: Q9EQV6
Re-Glyco: Q9EQV6

Annotation

Keyword: Autocatalytic cleavage Calcium Direct protein sequencing Disulfide bond Glycoprotein Lysosome Metal-binding Reference proteome Serine protease Signal Zymogen

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	Reference
proteolysis	ISS	PMID
proteolysis	ISO	GO_REF
proteolysis	IBA	GO_REF
proteolysis	IEA	GO_REF
lysosome organization	ISO	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

peptide catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

protein metabolic process [inference]

proteolysis

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

neuromuscular process [inference]

neuromuscular process controlling balance

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

bone resorption

developmental process [inference]

anatomical structure development [inference]

system development [inference]

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

bone resorption

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromosome, telomeric region

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
lysosome	ISS	PMID GO_REF
lysosome	ISO	GO_REF
lysosome	IEA	GO_REF
Golgi apparatus	ISS	GO_REF
Golgi apparatus	ISO	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

membrane microdomain [inference]

membrane raft

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

pigment granule [inference]

melanosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

pigment granule [inference]

melanosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

pigment granule [inference]

melanosome

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	Reference
endopeptidase activity	ISS	PMID
endopeptidase activity	ISO	GO_REF
endopeptidase activity	IDA	PMID
endopeptidase activity	IBA	GO_REF
serine-type endopeptidase activity	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

exopeptidase activity [inference]

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

exopeptidase activity [inference]

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

binding [inference]

lipid binding [inference]

phospholipid binding [inference]

lysophosphatidic acid binding

glycolipid binding [inference]

sulfatide binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

lysophosphatidic acid binding

cation binding [inference]

metal ion binding

peptide binding

carbohydrate derivative binding [inference]

lysophosphatidic acid binding

glycolipid binding [inference]

sulfatide binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGLQARFLGLLALVIAGKCTHSPEPDQRWMLPPGWVSLGRVDPEEELSLTFALKQQNLDRLSELVQAVSDPSSPRYGKYLTLEDVAELVQPSPLTLRTVQKWLLAAGARDCHSVTTQDFLTCWLSVRQAELLLPGAEFHRYVGGPAKTHIIRSPHPYQLPQALAPHVDLVAGLHRFPPLSSPRQRPEPQGVGPVGLHLGVTPSVLRQRYNLTARDVGSGTTNNSQACAQFLEQYFHNSDLTEFMRLFGSSFAHQASVARVVGKQGRGRAGIEASLDVEYLMSAGANISTWVYSSPGRHEAQEPFLQWLLLLSNESSLPHVHTVSYGDDEDSLSSVYIQRVNTEFMKAAARGLTLLFASGDTGAGCWSVSGRHKFRPSFPASSPYVTTVGGTSFKNPFLVTNEVVDYISGGGFSNVFPQPSYQEEAVAQFLKSSSHLPPSSYFNASGRAYPDVAALSDGYWVVSNMVPIPWVSGTSASTPVFGGILSLINEHRLLNGRPPLGFLNPRLYQQHGAGLFDVTHGCHESCLNEEVEGQGFCSGPGWDPVTGWGTPNFPALLKTLLNP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
210	N-linked (GlcNAc...) asparagine	24090084	G09775CH G31852PQ G37135JQ	UniProt GlyGen
222	N-linked (GlcNAc...) asparagine	24090084	G02815KT	UniProt GlyGen
286	N-linked (GlcNAc...) asparagine			UniProt GlyGen
313	N-linked (GlcNAc...) asparagine			UniProt GlyGen
443	N-linked (GlcNAc...) asparagine	24090084	G41247ZX G02815KT G20956ZV G28681TP	UniProt GlyGen