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Rap guanine nucleotide exchange factor 4

Summary

UniProt ID: Q9EQZ6
Gene Symbol: Rapgef4 Cgef2 Epac2
Gene ID: 56508
Organism: Mus musculus (house mouse)

External Links

GlyGen: Q9EQZ6
PubChem: Q9EQZ6
Re-Glyco: Q9EQZ6

Annotation

Keyword: 3D-structure Alternative promoter usage Alternative splicing Cytoplasm Exocytosis Guanine-nucleotide releasing factor Membrane Reference proteome Repeat cAMP-binding

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	Reference
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA	PMID
adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	PMID PMID PMID
adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	PMID PMID
Ras protein signal transduction
positive regulation of smooth muscle cell migration	ISO	GO_REF

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

small GTPase-mediated signal transduction [inference]

Ras protein signal transduction

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

calcium-ion regulated exocytosis

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

calcium-ion regulated exocytosis

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion

peptide hormone secretion [inference]

insulin secretion

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

establishment of localization [inference]

transport [inference]

hormone transport [inference]

hormone secretion

peptide hormone secretion [inference]

insulin secretion

protein transport [inference]

protein secretion [inference]

insulin secretion

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

calcium-ion regulated exocytosis

secretion [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

calcium-ion regulated exocytosis

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion

peptide hormone secretion [inference]

insulin secretion

nitrogen compound transport [inference]

peptide hormone secretion [inference]

insulin secretion

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

calcium-ion regulated exocytosis

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion

peptide hormone secretion [inference]

insulin secretion

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

negative regulation of synaptic transmission

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of protein localization to synapse [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

positive regulation of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of protein localization to cell periphery [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of protein localization to membrane [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of transport [inference]

regulation of secretion [inference]

regulation of peptide secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

regulation of secretion by cell [inference]

regulation of exocytosis

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion

regulation of protein secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of vesicle-mediated transport [inference]

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion

regulation of cellular localization [inference]

regulation of protein localization to membrane [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of receptor localization to synapse [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration [inference]

positive regulation of smooth muscle cell migration

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

positive regulation of action potential [inference]

positive regulation of neuronal action potential

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of transmission of nerve impulse [inference]

positive regulation of neuronal action potential

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system process [inference]

positive regulation of transmission of nerve impulse [inference]

positive regulation of neuronal action potential

positive regulation of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission

regulation of developmental process [inference]

regulation of dendrite development

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

small GTPase-mediated signal transduction [inference]

Ras protein signal transduction

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of transmission of nerve impulse [inference]

positive regulation of neuronal action potential

negative regulation of cell communication [inference]

negative regulation of synaptic transmission

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion

regulation of transmission of nerve impulse [inference]

positive regulation of transmission of nerve impulse [inference]

positive regulation of neuronal action potential

regulation of neuronal action potential [inference]

positive regulation of neuronal action potential

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

negative regulation of synaptic transmission

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of transmission of nerve impulse [inference]

positive regulation of neuronal action potential

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of dendrite development

regulation of synapse organization [inference]

regulation of postsynapse organization

regulation of cellular localization [inference]

regulation of protein localization to membrane [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of vesicle-mediated transport [inference]

regulation of secretion by cell [inference]

regulation of exocytosis

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion

regulation of protein secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration [inference]

positive regulation of smooth muscle cell migration

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

positive regulation of nervous system process [inference]

positive regulation of transmission of nerve impulse [inference]

positive regulation of neuronal action potential

regulation of transmission of nerve impulse [inference]

positive regulation of transmission of nerve impulse [inference]

positive regulation of neuronal action potential

regulation of neuronal action potential [inference]

positive regulation of neuronal action potential

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system process [inference]

positive regulation of transmission of nerve impulse [inference]

positive regulation of neuronal action potential

regulation of action potential [inference]

positive regulation of action potential [inference]

positive regulation of neuronal action potential

regulation of neuronal action potential [inference]

positive regulation of neuronal action potential

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion

peptide hormone secretion [inference]

insulin secretion

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion

regulation of membrane potential [inference]

regulation of action potential [inference]

positive regulation of action potential [inference]

positive regulation of neuronal action potential

regulation of neuronal action potential [inference]

positive regulation of neuronal action potential

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	Reference
photoreceptor outer segment	ISO	GO_REF
photoreceptor inner segment	ISO	GO_REF
cytosol	ISO	GO_REF
cytosol	IDA	PMID
cytosol	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

cell junction [inference]

synapse [inference]

neuron to neuron synapse [inference]

hippocampal mossy fiber to CA3 synapse

site of polarized growth [inference]

growth cone

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

neuron spine [inference]

dendritic spine

organelle [inference]

postsynaptic specialization [inference]

postsynaptic density

cell body [inference]

neuronal cell body

neuron projection terminus [inference]

axon terminus [inference]

cone cell pedicle

presynapse

axon terminus [inference]

cone cell pedicle

postsynapse [inference]

dendritic spine

cluster of actin-based cell projections [inference]

brush border

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
guanyl-nucleotide exchange factor activity	ISO	GO_REF GO_REF
guanyl-nucleotide exchange factor activity	IDA	PMID PMID
guanyl-nucleotide exchange factor activity	IGI	PMID
guanyl-nucleotide exchange factor activity	IBA	GO_REF
guanyl-nucleotide exchange factor activity	IEA	GO_REF GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

cAMP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

cyclic nucleotide binding [inference]

cAMP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

protein-containing complex binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

cyclic nucleotide binding [inference]

cAMP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MVAAHAAHSQSSAEWIACLDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDNTPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPAHTITKVPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEREDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRAANQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVFMPNTQLCPALVAHYHAQPSQGTEQERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMAFLEEFYVSVSDDARMMAAFKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEKVVLKSNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
761				GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	Mus musculus
Integrin signaling	Mus musculus
Rap1 signalling	Mus musculus
Regulation of insulin secretion	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

International Collaboration

Acknowledgements