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Carbohydrate sulfotransferase 6

Summary

UniProt ID: Q9GZX3
Gene Symbol: CHST6
Gene ID: 4166
Organism: Homo sapiens (human)

External Links

GlyGen: Q9GZX3
The Human Metabolome Database: HMDBP02328
RaftProt: Q9GZX3
Re-Glyco: Q9GZX3

Annotation

Keyword: Carbohydrate metabolism Corneal dystrophy Disease variant Glycoprotein Golgi apparatus Proteomics identification Reference proteome Signal-anchor Transferase Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
carbohydrate metabolic process	IEA	GO_REF
N-acetylglucosamine metabolic process	IC	PMID
N-acetylglucosamine metabolic process	IDA	PMID
N-acetylglucosamine metabolic process	IBA	GO_REF
N-acetylglucosamine metabolic process	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

sulfur compound metabolic process

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

keratan sulfate proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

keratan sulfate proteoglycan biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

keratan sulfate proteoglycan biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

keratan sulfate proteoglycan biosynthetic process

keratan sulfate proteoglycan metabolic process [inference]

keratan sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

keratan sulfate proteoglycan biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

keratan sulfate proteoglycan biosynthetic process

keratan sulfate proteoglycan metabolic process [inference]

keratan sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

keratan sulfate proteoglycan biosynthetic process

carbohydrate derivative metabolic process [inference]

amino sugar metabolic process [inference]

N-acetylglucosamine metabolic process

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

keratan sulfate proteoglycan biosynthetic process

keratan sulfate proteoglycan metabolic process [inference]

keratan sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

keratan sulfate proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

keratan sulfate proteoglycan biosynthetic process

Displaying **all 4** entries
GO Term	Evidence Code	Reference
Golgi membrane	TAS	Reactome Reactome
Golgi membrane	IEA	GO_REF GO_REF GO_REF
Golgi apparatus	TAS	PMID
trans-Golgi network	IBA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
N-acetylglucosamine 6-O-sulfotransferase activity	TAS	PMID Reactome Reactome
N-acetylglucosamine 6-O-sulfotransferase activity	IDA	PMID PMID
N-acetylglucosamine 6-O-sulfotransferase activity	IBA	GO_REF
N-acetylglucosamine 6-O-sulfotransferase activity	IEA	GO_REF
keratan sulfotransferase activity	EXP	PMID

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring sulphur-containing groups [inference]

sulfotransferase activity [inference]

N-acetylglucosamine 6-O-sulfotransferase activity

proteoglycan sulfotransferase activity [inference]

keratan sulfotransferase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MWLPRVSSTAVTALLLAQTFLLLFLVSRPGPSSPAGGEARVHVLVLSSWRSGSSFVGQLFNQHPDVFYLMEPAWHVWTTLSQGSAATLHMAVRDLVRSVFLCDMDVFDAYLPWRRNLSDLFQWAVSRALCSPPACSAFPRGAISSEAVCKPLCARQSFTLAREACRSYSHVVLKEVRFFNLQVLYPLLSDPALNLRIVHLVRDPRAVLRSREQTAKALARDNGIVLGTNGTWVEADPGLRVVREVCRSHVRIAEAATLKPPPFLRGRYRLVRFEDLAREPLAEIRALYAFTGLSLTPQLEAWIHNITHGSGPGARREAFKTSSRNALNVSQAWRHALPFAKIRRVQELCAGALQLLGYRPVYSEDEQRNLALDLVLPRGLNGFTWASSTASHPRN

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	Source
116	N-linked (GlcNAc...) asparagine	UniProt GlyGen
229	N-linked (GlcNAc...) asparagine	UniProt GlyGen
305	N-linked (GlcNAc...) asparagine	UniProt GlyGen
328	N-linked (GlcNAc...) asparagine	UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Defective CHST6 causes MCDC1	Homo sapiens
Keratan sulfate biosynthesis	Homo sapiens

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:2565	macular corneal dystrophy	Glyco-Disease Genes Database Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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External Links

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International Collaboration

Acknowledgements