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Fibroblast growth factor receptor 3

Summary

UniProt ID: Q9I8X3
Gene Symbol: fgfr3
Gene ID
Organism: Danio rerio (zebrafish)

External Links

PubChem: Q9I8X3
Re-Glyco: Q9I8X3

Annotation

Keyword: ATP-binding Apoptosis Cell membrane Disulfide bond Glycoprotein Immunoglobulin domain Phosphoprotein Receptor Reference proteome Repeat Signal Transmembrane helix Tyrosine-protein kinase

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
apoptotic process
positive regulation of cell population proliferation	IBA	GO_REF
positive regulation of cell population proliferation	IEA	GO_REF
fibroblast growth factor receptor signaling pathway	IBA	GO_REF
fibroblast growth factor receptor signaling pathway	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of hematopoietic progenitor cell differentiation [inference]

regulation of hematopoietic stem cell differentiation

regulation of stem cell differentiation [inference]

regulation of hematopoietic stem cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of cell differentiation [inference]

regulation of hematopoietic progenitor cell differentiation [inference]

regulation of hematopoietic stem cell differentiation

regulation of stem cell differentiation [inference]

regulation of hematopoietic stem cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

Displaying **all 3** entries
GO Term	Evidence Code	Reference
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF
signaling receptor complex	IBA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	Reference
fibroblast growth factor receptor activity	IBA	GO_REF
fibroblast growth factor receptor activity	IEA	GO_REF
ATP binding	IEA	GO_REF
fibroblast growth factor binding	IBA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

fibroblast growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

fibroblast growth factor receptor activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

fibroblast growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

fibroblast growth factor receptor activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

fibroblast growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

fibroblast growth factor receptor activity

binding [inference]

protein binding [inference]

growth factor binding [inference]

fibroblast growth factor binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

fibroblast growth factor receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MVPLCLLLYLATLVFPPVYSAHLLSPEPTDWVSSEVEVFLEDYVAGVGDTVVLSCTPQDFLLPIVWQKDGDAVSSSNRTRVGQKALRIINVSYEDSGVYSCRHAHKSMLLSNYTVKVIDSLSSGDDEDYDEDEDEAGNGNAEAPYWTRSDRMEKKLLAVPAANTVKFRCPAAGNPTPSIHWLKNGKEFKGEQRMGGIKLRHQQWSLVMESAVPSDRGNYTCVVQNKYGSIKHTYQLDVLERSPHRPILQAGLPANQTVVVGSDVEFHCKVYSDAQPHIQWLKHIEVNGSQYGPNGAPYVNVLKTAGINTTDKELEILYLTNVSFEDAGQYTCLAGNSIGYNHHSAWLTVLPAVEMEREDDYADILIYVTSCVLFILTMVIIILCRMWINTQKTLPAPPVQKLSKFPLKRQVSLESNSSMNSNTPLVRIARLSSSDGPMLPNVSELELPSDPKWEFTRTKLTLGKPLGEGCFGQVVMAEAIGIDKEKPNKPLTVAVKMLKDDGTDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLRARRPPGMDYSFDTCKIPNETLTFKDLVSCAYQVARGMEYLASKKCIHRDPAARNVLVTEDNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSYGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHELYMIMRECWHAVPSQRPTFRQLVEDHDRVLSMTSTDEYLDLSVPFEQYSPTCPDSNSTCSSGDDSVFAHDPLPEEPCLPKHHHSNGVIRT

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 8** entries
Position	Description	Source
77	N-linked (GlcNAc...) asparagine	UniProt
90	N-linked (GlcNAc...) asparagine	UniProt
112	N-linked (GlcNAc...) asparagine	UniProt
218	N-linked (GlcNAc...) asparagine	UniProt
255	N-linked (GlcNAc...) asparagine	UniProt
287	N-linked (GlcNAc...) asparagine	UniProt
308	N-linked (GlcNAc...) asparagine	UniProt
321	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 11 in total

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Pathway Name	Organism
FGFR3b ligand binding and activation	Danio rerio
FGFR3c ligand binding and activation	Danio rerio
FRS-mediated FGFR3 signaling	Danio rerio
Negative regulation of FGFR3 signaling	Danio rerio
PI-3K cascade:FGFR3	Danio rerio
PI3K Cascade	Danio rerio
PI3K/AKT Signaling	Danio rerio
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Danio rerio
Phospholipase C-mediated cascade; FGFR3	Danio rerio
RAF/MAP kinase cascade	Danio rerio

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111160	camptodactyly-tall stature-scoliosis-hearing loss syndrome	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

International Collaboration

Acknowledgements