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MIRAGE

Cathepsin 8

Summary

UniProt ID: Q9JI81
Gene Symbol: Cts8 Cts2 Epcs68 Epcs70
Gene ID: 56094
Organism: Mus musculus (house mouse)

External Links

Re-Glyco: Q9JI81

Annotation

Keyword: Disulfide bond Endosome Glycoprotein Lysosome Reference proteome Secreted Signal Thiol protease Zymogen

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	Reference
blood vessel remodeling	IMP	PMID
proteolysis	ISA	PMID
proteolysis	ISO	GO_REF
proteolysis	IEA	GO_REF
protein autoprocessing	ISO	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

collagen catabolic process

collagen metabolic process [inference]

collagen catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein metabolic process [inference]

protein processing [inference]

protein catabolic process

protein maturation [inference]

protein processing [inference]

primary metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

protein catabolic process

protein maturation [inference]

protein processing [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

cellular developmental process [inference]

cell differentiation [inference]

cell differentiation involved in embryonic placenta development [inference]

trophoblast giant cell differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

membrane fusion [inference]

fusion of virus membrane with host plasma membrane

viral process [inference]

membrane fusion involved in viral entry into host cell [inference]

reproductive process [inference]

developmental process involved in reproduction [inference]

cell differentiation involved in embryonic placenta development [inference]

trophoblast giant cell differentiation

multicellular organismal process [inference]

tissue remodeling [inference]

blood vessel remodeling

developmental process [inference]

developmental process involved in reproduction [inference]

cell differentiation involved in embryonic placenta development [inference]

trophoblast giant cell differentiation

cellular developmental process [inference]

cell differentiation [inference]

cell differentiation involved in embryonic placenta development [inference]

trophoblast giant cell differentiation

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

symbiont entry into host [inference]

symbiont entry into host cell

endocytosis involved in viral entry into host cell [inference]

receptor-mediated endocytosis of virus by host cell

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
extracellular region	ISO	GO_REF
extracellular region	IDA	PMID
extracellular region	IEA	GO_REF
obsolete extracellular space
lysosome	ISO	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
fibronectin binding	ISO	GO_REF
cysteine-type endopeptidase activity	ISO	GO_REF
collagen binding	ISO	GO_REF
peptidase activity	ISA	PMID
cysteine-type peptidase activity	ISO	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity

cysteine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity

cysteine-type endopeptidase activity

binding [inference]

protein binding [inference]

protein-containing complex binding [inference]

collagen binding

carbohydrate derivative binding [inference]

proteoglycan binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGPAVLLAILCLGVAEVTQSSDPSLDSEWQEWKRKFNKNYSMEEEGQKRAVWEENMKLVKQHNIEYDQGKKNFTMDVNAFGDMTGEEYRKMLTDIPVPNFRKKKSIHQPIAGYLPKFVDWRKRGCVTPVKNQGTCNSCWAFSAAGAIEGQMFRKTGKLVPLSTQNLVDCSRLEGNFGCFKGSTFLALKYVWKNRGLEAESTYPYKGTDGHCRYHPERSAARITSFSFVSNSEKDLMRAVATIGPISVGIDARHKSFRLYREGIYYEPKCSSNIINHSVLVVGYGYEGKESDGNKYWLIKNSHGEQWGMNGYMKLARGRNNHCGIASYAVYPRV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
39	N-linked (GlcNAc...) asparagine			UniProt
72	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026