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Signal peptide peptidase-like 2A

Summary

UniProt ID: Q9JJF9
Gene Symbol: Imp3 MNCb-3763 Psl2 Sppl2a
Gene ID: 66552
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0007569
PubChem: Q9JJF9
Re-Glyco: Q9JJF9

Annotation

Keyword: Endosome Glycoprotein Lysosome Protease Reference proteome Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	Reference
membrane protein ectodomain proteolysis	ISS	GO_REF
membrane protein ectodomain proteolysis	ISO	GO_REF
membrane protein ectodomain proteolysis	IEA	GO_REF
membrane protein intracellular domain proteolysis	ISS	GO_REF
membrane protein intracellular domain proteolysis	ISO	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune response

regulation of response to stimulus [inference]

regulation of immune response

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	Reference
lysosomal membrane	IDA	PMID
lysosomal membrane	IBA	GO_REF
lysosomal membrane	IEA	GO_REF
late endosome	ISO	GO_REF
late endosome	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

late endosome membrane

Golgi-associated vesicle membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane [inference]

late endosome membrane

Golgi-associated vesicle membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of endoplasmic reticulum membrane

lumenal side of membrane [inference]

lumenal side of endoplasmic reticulum membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
aspartic endopeptidase activity, intramembrane cleaving	ISS	GO_REF
aspartic endopeptidase activity, intramembrane cleaving	ISO	GO_REF
aspartic endopeptidase activity, intramembrane cleaving	IBA	GO_REF
aspartic endopeptidase activity, intramembrane cleaving	IEA	GO_REF GO_REF
protein homodimerization activity	ISS	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGLLHSLHAPAAALLWSCLLGLAAAQEAILHASTNGVSSLSKDYCMYYNNNWTRLPSSLENATSLSLMNLTGTALCHLSDIPPDGIRNKAVVVHWGPCHFLEKARIAQEGGAAALLIANNSVLIPSSRNKSTFQNVTVLIAVITQKDFKDMKETLGDDITVKMYSPSWPNFDYTLVVIFVIAVFTVALGGYWSGLIELENMKSVEDAEDRETRKKKDDYLTFSPLTVVVFVVICCIMIVLLYFFYRWLVYVMIAIFCIASSMSLYNCLSALIHRMPCGQCTILCCGKNIKVSLIFLSGLCISVAVVWAVFRNEDRWAWILQDILGIAFCLNLIKTMKLPNFMSCVILLGLLLIYDVFFVFITPFITKNGESIMVELAAGPFENAEKLPVVIRVPKLMGYSVMSVCSVPVSVLGFGDIIVPGLLIAYCRRFDVQTGSSIYYISSTIAYAVGMIITFVVLMVMKTGQPALLYLVPCTLITVSVVAWSRKEMKKFWKGSSYQVMDHLDYSTNEENPVTTDEQIVQQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	Source
51	N-linked (GlcNAc...) asparagine	GlycoProtDB UniProt
61	N-linked (GlcNAc...) asparagine	GlycoProtDB UniProt
69	N-linked (GlcNAc...) asparagine	GlycoProtDB UniProt
119	N-linked (GlcNAc...) asparagine	GlycoProtDB UniProt
129	N-linked (GlcNAc...) asparagine	GlycoProtDB UniProt
135	N-linked (GlcNAc...) asparagine	GlycoProtDB UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Regulation of TNFR1 signaling	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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External Links

Annotation

International Collaboration

Acknowledgements