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Ubiquitin carboxyl-terminal hydrolase 14

Summary

UniProt ID: Q9JMA1
Gene Symbol: Usp14
Gene ID: 59025
Organism: Mus musculus (house mouse)

External Links

GlyGen: Q9JMA1
PubChem: Q9JMA1
Re-Glyco: Q9JMA1

Annotation

Keyword: 3D-structure Acetylation Cell membrane Cytoplasm Innate immunity Phosphoprotein Proteasome Reference proteome Thiol protease Ubl conjugation pathway

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	Reference
inflammatory response	ISO	GO_REF
inflammatory response	IEA	GO_REF
chemical synaptic transmission	IMP	PMID
proteasome-mediated ubiquitin-dependent protein catabolic process	IEA	GO_REF
innate immune response

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination [inference]

protein K48-linked deubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination [inference]

protein K48-linked deubiquitination

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination [inference]

protein K48-linked deubiquitination

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of locomotion [inference]

regulation of chemotaxis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of ERAD pathway

negative regulation of response to stimulus [inference]

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of ERAD pathway

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of chemotaxis

negative regulation of response to stimulus [inference]

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of ERAD pathway

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of ERAD pathway

regulation of ERAD pathway [inference]

negative regulation of ERAD pathway

regulation of cellular process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

regulation of proteasomal protein catabolic process

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

regulation of ERAD pathway [inference]

negative regulation of ERAD pathway

regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of ubiquitin-dependent protein catabolic process

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

regulation of proteasomal protein catabolic process

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

regulation of ERAD pathway [inference]

negative regulation of ERAD pathway

regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of ubiquitin-dependent protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

regulation of proteasomal protein catabolic process

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

regulation of ERAD pathway [inference]

negative regulation of ERAD pathway

regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of ubiquitin-dependent protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of ERAD pathway

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of ERAD pathway

regulation of ERAD pathway [inference]

negative regulation of ERAD pathway

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	Reference
proteasome complex
nucleolus	ISO	GO_REF
cytoplasm	ISO	GO_REF
cytoplasm	IEA	GO_REF GO_REF
endoplasmic reticulum	ISO	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

proteasome complex

catalytic complex [inference]

peptidase complex [inference]

endopeptidase complex [inference]

proteasome complex

cellular anatomical structure [inference]

cytoplasm

cytosol

presynaptic cytosol

cell surface

membrane [inference]

plasma membrane

cell junction [inference]

synapse

glutamatergic synapse

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membraneless organelle [inference]

nucleolus

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
cysteine-type deubiquitinase activity	ISS	GO_REF
cysteine-type deubiquitinase activity	ISO	GO_REF
cysteine-type deubiquitinase activity	IBA	GO_REF
cysteine-type deubiquitinase activity	IEA	GO_REF GO_REF GO_REF
endopeptidase inhibitor activity	ISO	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

cysteine-type peptidase activity [inference]

cysteine-type deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

cysteine-type peptidase activity [inference]

cysteine-type deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity

binding [inference]

protein-containing complex binding [inference]

proteasome binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGNIKMKNGMTVLMMGSADALPEEPSAKTVFVEDMTEEQLATAMELPCGLTNLGNTCYMNATVQCIRSVPELKDALKRYAGALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQFLHMAFPQFAEKGEQGQYLQQDANECWIQMMRVLQQKLEAIEDDSGRETDSSSAPAVTPSKKKSLIDQYFGVEFETTMKCTESEEEEVTKGKENQLQLSCFINQEVKYLFTGLKLRLQEEITKQSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDVYELCTPELQEKMVSFRSKFKDLEDKKVNQQPNANDKNSPPKEIKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVRRKQDEWIKFDDDKVSIVTPEDILRLSGGGDWHIAYVLLYGPRRVEIMEEESEQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
235				GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Regulation of NF-kappa B signaling	Mus musculus
Ub-specific processing proteases	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

International Collaboration

Acknowledgements