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Mu-type opioid receptor

Summary

UniProt ID: Q9MYW9
Gene Symbol: OPRM1 MOR1
Gene ID: 574141
Organism: Macaca mulatta (Rhesus monkey)

External Links

PubChem: Q9MYW9
Re-Glyco: Q9MYW9

Annotation

Keyword: Cell membrane Cell projection Disulfide bond Endosome G-protein coupled receptor Glycoprotein Palmitate Phosphoprotein Reference proteome Transmembrane helix Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	Reference
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISS	GO_REF
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	ISS	GO_REF
phospholipase C-activating G protein-coupled receptor signaling pathway	ISS	GO_REF
neuropeptide signaling pathway	IBA	GO_REF
sensory perception of pain	ISS	GO_REF

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

G protein-coupled acetylcholine receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway [inference]

G protein-coupled acetylcholine receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of pain

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of NMDA receptor activity

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of signaling [inference]

negative regulation of Wnt protein secretion

regulation of Wnt protein secretion [inference]

negative regulation of Wnt protein secretion

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of Wnt protein secretion

regulation of Wnt protein secretion [inference]

negative regulation of Wnt protein secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of Wnt protein secretion

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of Wnt protein secretion

negative regulation of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of Wnt protein secretion

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of NMDA receptor activity

regulation of secretion [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion [inference]

negative regulation of Wnt protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of Wnt protein secretion

regulation of Wnt protein secretion [inference]

negative regulation of Wnt protein secretion

negative regulation of secretion by cell [inference]

negative regulation of protein secretion [inference]

negative regulation of Wnt protein secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion [inference]

negative regulation of Wnt protein secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of Wnt protein secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of Wnt protein secretion

regulation of Wnt protein secretion [inference]

negative regulation of Wnt protein secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of Wnt protein secretion

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of Wnt protein secretion

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

negative regulation of cell communication [inference]

negative regulation of Wnt protein secretion

negative regulation of secretion by cell [inference]

negative regulation of protein secretion [inference]

negative regulation of Wnt protein secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion [inference]

negative regulation of Wnt protein secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of Wnt protein secretion

negative regulation of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of Wnt protein secretion

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of Wnt protein secretion

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of NMDA receptor activity

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

G protein-coupled acetylcholine receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway [inference]

G protein-coupled acetylcholine receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of NMDA receptor activity

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of cell communication [inference]

negative regulation of Wnt protein secretion

regulation of Wnt protein secretion [inference]

negative regulation of Wnt protein secretion

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

regulation of nitric oxide metabolic process [inference]

regulation of nitric oxide biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of NMDA receptor activity

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

negative regulation of cell communication [inference]

negative regulation of Wnt protein secretion

negative regulation of secretion by cell [inference]

negative regulation of protein secretion [inference]

negative regulation of Wnt protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of Wnt protein secretion

regulation of Wnt protein secretion [inference]

negative regulation of Wnt protein secretion

negative regulation of secretion by cell [inference]

negative regulation of protein secretion [inference]

negative regulation of Wnt protein secretion

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

regulation of biological quality [inference]

negative regulation of cytosolic calcium ion concentration

regulation of molecular function [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of NMDA receptor activity

regulation of transmembrane transporter activity [inference]

regulation of NMDA receptor activity

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	Reference
endosome	ISS	GO_REF
endosome	IEA	GO_REF
plasma membrane	ISS	GO_REF
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
G-protein alpha-subunit binding	ISS	GO_REF
G-protein alpha-subunit binding	IBA	GO_REF
G protein-coupled receptor activity	ISS	GO_REF
G protein-coupled receptor activity	IEA	GO_REF
beta-endorphin receptor activity	IBA	GO_REF

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

monoatomic cation channel activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

monoatomic cation channel activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

binding [inference]

protein binding [inference]

peptide binding [inference]

neuropeptide binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

melanocortin receptor activity [inference]

beta-endorphin receptor activity

neuropeptide receptor activity [inference]

beta-endorphin receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled opioid receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

melanocortin receptor activity [inference]

beta-endorphin receptor activity

neuropeptide receptor activity [inference]

beta-endorphin receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MDSSAVPTNASNCTDALAHSSCSPARSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALVTSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMSTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPSWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIICWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDEDFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	Source
9	N-linked (GlcNAc...) asparagine	UniProt
12	N-linked (GlcNAc...) asparagine	UniProt
33	N-linked (GlcNAc...) asparagine	UniProt
40	N-linked (GlcNAc...) asparagine	UniProt
48	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

International Collaboration

Acknowledgements