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Phosphatidylinositol-3-phosphatase SAC1

Summary

UniProt ID: Q9NTJ5
Gene Symbol: KIAA0851 SAC1 SACM1L
Gene ID: 22908
Organism: Homo sapiens (human)

External Links

GlyGen: Q9NTJ5
PubChem: Q9NTJ5
RaftProt: Q9NTJ5
Re-Glyco: Q9NTJ5

Annotation

Keyword: Acetylation Alternative splicing Endoplasmic reticulum Golgi apparatus Hydrolase Lipid metabolism Proteomics identification Reference proteome Transmembrane helix

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
phosphatidylinositol biosynthetic process	TAS	Reactome Reactome
phosphatidylinositol biosynthetic process	IEA	GO_REF
phosphatidylinositol dephosphorylation	IDA	PMID
phosphatidylinositol dephosphorylation	IBA	GO_REF
exocytic insertion of neurotransmitter receptor to postsynaptic membrane	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

phosphatidylinositol metabolic process [inference]

biosynthetic process [inference]

phosphatidylinositol biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

vesicle-mediated transport [inference]

exocytosis [inference]

exocytic insertion of neurotransmitter receptor to postsynaptic membrane

vesicle-mediated transport in synapse

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

exocytic insertion of neurotransmitter receptor to postsynaptic membrane

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

exocytosis [inference]

exocytic insertion of neurotransmitter receptor to postsynaptic membrane

vesicle-mediated transport in synapse

secretion [inference]

secretion by cell [inference]

exocytosis [inference]

exocytic insertion of neurotransmitter receptor to postsynaptic membrane

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

exocytic insertion of neurotransmitter receptor to postsynaptic membrane

biological regulation [inference]

regulation of biological quality [inference]

regulation of postsynaptic membrane neurotransmitter receptor levels [inference]

exocytic insertion of neurotransmitter receptor to postsynaptic membrane

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GO Term	Evidence Code	Reference
Golgi membrane	EXP	PMID
Golgi membrane	TAS	Reactome Reactome
Golgi membrane	IDA	PMID
Golgi membrane	IEA	GO_REF
endoplasmic reticulum

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex [inference]

AMPA glutamate receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex [inference]

AMPA glutamate receptor complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex [inference]

AMPA glutamate receptor complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex [inference]

AMPA glutamate receptor complex

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

Golgi membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

organelle membrane contact site [inference]

endoplasmic reticulum-plasma membrane contact site

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GO Term	Evidence Code	Reference
phosphatidylinositol-3-phosphate phosphatase activity	ISS	GO_REF
phosphatidylinositol-3-phosphate phosphatase activity	TAS	Reactome
phosphatidylinositol-3-phosphate phosphatase activity	IEA	GO_REF GO_REF
phosphatase activity	ISS	GO_REF
phosphatase activity	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity

phosphatidylinositol phosphate phosphatase activity [inference]

phosphatidylinositol phosphate 4-phosphatase activity

phosphatidylinositol-4-phosphate phosphatase activity

phosphatidylinositol monophosphate phosphatase activity [inference]

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MATAAYEQLKLHITPEKFYVEACDDGADDVLTIDRVSTEVTLAVKKDVPPSAVTRPIFGILGTIHLVAGNYLIVITKKIKVGEFFSHVVWKATDFDVLSYKKTMLHLTDIQLQDNKTFLAMLNHVLNVDGFYFSTTYDLTHTLQRLSNTSPEFQEMSLLERADQRFVWNGHLLRELSAQPEVHRFALPVLHGFITMHSCSINGKYFDWILISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIVHYNGSKASFVQTRGSIPVFWSQRPNLKYKPLPQISKVANHMDGFQRHFDSQVIIYGKQVIINLINQKGSEKPLEQTFATMVSSLGSGMMRYIAFDFHKECKNMRWDRLSILLDQVAEMQDELSYFLVDSAGQVVANQEGVFRSNCMDCLDRTNVIQSLLARRSLQAQLQRLGVLHVGQKLEEQDEFEKIYKNAWADNANACAKQYAGTGALKTDFTRTGKRTHLGLIMDGWNSMIRYYKNNFSDGFRQDSIDLFLGNYSVDELESHSPLSVPRDWKFLALPIIMVVAFSMCIICLLMAGDTWTETLAYVLFWGVASIGTFFIILYNGKDFVDAPRLVQKEKID

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites