GlyCosmos Portal

[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

Summary

UniProt ID: Q9P0J1
Gene Symbol: PDP PDP1 PPM2C
Gene ID: 54704
Organism: Homo sapiens (human)

External Links

PubChem: Q9P0J1
The Human Metabolome Database: HMDBP08786
The O-GlcNAc Database: Q9P0J1
O-GlcNAcAtlas: Q9P0J1
Re-Glyco: Q9P0J1

Annotation

Keyword: Acetylation Alternative splicing Calcium Disease variant Magnesium Manganese Metal-binding Mitochondrion Protein phosphatase Proteomics identification Reference proteome Transit peptide

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	Reference
peptidyl-threonine dephosphorylation	IDA	PMID
positive regulation of pyruvate decarboxylation to acetyl-CoA	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation [inference]

peptidyl-threonine dephosphorylation

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-threonine dephosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-threonine dephosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-threonine dephosphorylation

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of acetyl-CoA biosynthesis [inference]

positive regulation of pyruvate decarboxylation to acetyl-CoA

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of acetyl-CoA biosynthesis [inference]

positive regulation of pyruvate decarboxylation to acetyl-CoA

positive regulation of small molecule metabolic process [inference]

positive regulation of acetyl-CoA biosynthesis [inference]

positive regulation of pyruvate decarboxylation to acetyl-CoA

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of acetyl-CoA biosynthesis [inference]

positive regulation of pyruvate decarboxylation to acetyl-CoA

regulation of acyl-CoA biosynthetic process [inference]

regulation of pyruvate decarboxylation to acetyl-CoA [inference]

positive regulation of pyruvate decarboxylation to acetyl-CoA

positive regulation of acetyl-CoA biosynthesis [inference]

positive regulation of pyruvate decarboxylation to acetyl-CoA

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of acetyl-CoA biosynthesis [inference]

positive regulation of pyruvate decarboxylation to acetyl-CoA

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of acetyl-CoA biosynthesis [inference]

positive regulation of pyruvate decarboxylation to acetyl-CoA

positive regulation of small molecule metabolic process [inference]

positive regulation of acetyl-CoA biosynthesis [inference]

positive regulation of pyruvate decarboxylation to acetyl-CoA

regulation of ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of pyruvate decarboxylation to acetyl-CoA [inference]

positive regulation of pyruvate decarboxylation to acetyl-CoA

positive regulation of acetyl-CoA biosynthesis [inference]

positive regulation of pyruvate decarboxylation to acetyl-CoA

regulation of sulfur metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of pyruvate decarboxylation to acetyl-CoA [inference]

positive regulation of pyruvate decarboxylation to acetyl-CoA

positive regulation of acetyl-CoA biosynthesis [inference]

positive regulation of pyruvate decarboxylation to acetyl-CoA

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of acetyl-CoA biosynthesis [inference]

positive regulation of pyruvate decarboxylation to acetyl-CoA

regulation of acyl-CoA biosynthetic process [inference]

regulation of pyruvate decarboxylation to acetyl-CoA [inference]

positive regulation of pyruvate decarboxylation to acetyl-CoA

positive regulation of acetyl-CoA biosynthesis [inference]

positive regulation of pyruvate decarboxylation to acetyl-CoA

regulation of small molecule metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of pyruvate decarboxylation to acetyl-CoA [inference]

positive regulation of pyruvate decarboxylation to acetyl-CoA

positive regulation of acetyl-CoA biosynthesis [inference]

positive regulation of pyruvate decarboxylation to acetyl-CoA

positive regulation of small molecule metabolic process [inference]

positive regulation of acetyl-CoA biosynthesis [inference]

positive regulation of pyruvate decarboxylation to acetyl-CoA

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of pyruvate decarboxylation to acetyl-CoA [inference]

positive regulation of pyruvate decarboxylation to acetyl-CoA

positive regulation of acetyl-CoA biosynthesis [inference]

positive regulation of pyruvate decarboxylation to acetyl-CoA

regulation of nucleobase-containing compound metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of pyruvate decarboxylation to acetyl-CoA [inference]

positive regulation of pyruvate decarboxylation to acetyl-CoA

positive regulation of acetyl-CoA biosynthesis [inference]

positive regulation of pyruvate decarboxylation to acetyl-CoA

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of acetyl-CoA biosynthesis [inference]

positive regulation of pyruvate decarboxylation to acetyl-CoA

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of acetyl-CoA biosynthesis [inference]

positive regulation of pyruvate decarboxylation to acetyl-CoA

positive regulation of small molecule metabolic process [inference]

positive regulation of acetyl-CoA biosynthesis [inference]

positive regulation of pyruvate decarboxylation to acetyl-CoA

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
mitochondrion	NAS	PMID
mitochondrion	IDA	PMID GO_REF
mitochondrion	IBA	GO_REF
mitochondrion	IEA	GO_REF
mitochondrion	HTP	PMID

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

phosphatase complex [inference]

protein serine/threonine phosphatase complex [inference]

pyruvate dehydrogenase (lipoamide) phosphatase complex

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 6 in total

1

2

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GO Term	Evidence Code	Reference
protein serine/threonine phosphatase activity	IDA	PMID
protein serine/threonine phosphatase activity	IEA	GO_REF
[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity	IDA	PMID PMID
[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity	IBA	GO_REF
[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity	IEA	GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

phosphoprotein phosphatase activity [inference]

protein serine/threonine phosphatase activity

[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein serine/threonine phosphatase activity

[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MPAPTQLFFPLIRNCELSRIYGTACYCHHKHLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQYTQGRRYASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRHAVGNNEFGTVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQE

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
87		29351928	G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Regulation of pyruvate dehydrogenase (PDH) complex	Homo sapiens

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:9970	obesity	Alliance of Genome Resources
DOID:3649	pyruvate decarboxylase deficiency	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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External Links

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International Collaboration

Acknowledgements