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Sentrin-specific protease 1

Summary

UniProt ID: Q9P0U3
Gene Symbol: SENP1
Gene ID: 29843
Organism: Homo sapiens (human)

External Links

GlyGen: Q9P0U3
PubChem: Q9P0U3
Re-Glyco: Q9P0U3

Annotation

Keyword: 3D-structure Alternative splicing Cytoplasm Nucleus Phosphoprotein Proteomics identification Reference proteome Thiol protease Ubl conjugation pathway

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
regulation of definitive erythrocyte differentiation
protein sumoylation	TAS	Reactome
protein sumoylation	IEA	GO_REF GO_REF
protein desumoylation	IMP	PMID
negative regulation of proteasomal ubiquitin-dependent protein catabolic process

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

protein modification by small protein removal [inference]

protein desumoylation

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

protein modification by small protein removal [inference]

protein desumoylation

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

protein modification by small protein removal [inference]

protein desumoylation

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of erythrocyte differentiation [inference]

regulation of definitive erythrocyte differentiation

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of erythrocyte differentiation [inference]

regulation of definitive erythrocyte differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of erythrocyte differentiation [inference]

regulation of definitive erythrocyte differentiation

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

post-transcriptional regulation of gene expression [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of RNA stability [inference]

regulation of mRNA stability

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

post-transcriptional regulation of gene expression [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of cell differentiation [inference]

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of erythrocyte differentiation [inference]

regulation of definitive erythrocyte differentiation

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of postsynapse organization [inference]

regulation of postsynapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of erythrocyte differentiation [inference]

regulation of definitive erythrocyte differentiation

regulation of biological quality [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
nucleus	EXP	PMID PMID PMID
nucleus	TAS	PMID
nucleus	IEA	GO_REF
nucleoplasm	TAS	Reactome Reactome Reactome
nucleoplasm	IDA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

nucleoplasm

cytosol [inference]

membrane [inference]

organelle membrane [inference]

nuclear membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
endopeptidase activity	TAS	PMID
deSUMOylase activity	ISS	GO_REF
deSUMOylase activity	IBA	GO_REF
deSUMOylase activity	IEA	GO_REF
SUMO-specific endopeptidase activity	EXP	PMID PMID

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

cysteine-type endopeptidase activity [inference]

ubiquitin-like protein-specific endopeptidase activity [inference]

SUMO-specific endopeptidase activity

cysteine-type peptidase activity [inference]

cysteine-type endopeptidase activity [inference]

ubiquitin-like protein-specific endopeptidase activity [inference]

SUMO-specific endopeptidase activity

deSUMOylase activity

ubiquitin-like protein peptidase activity [inference]

deSUMOylase activity

ubiquitin-like protein-specific endopeptidase activity [inference]

SUMO-specific endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

cysteine-type endopeptidase activity [inference]

ubiquitin-like protein-specific endopeptidase activity [inference]

SUMO-specific endopeptidase activity

cysteine-type peptidase activity [inference]

cysteine-type endopeptidase activity [inference]

ubiquitin-like protein-specific endopeptidase activity [inference]

SUMO-specific endopeptidase activity

deSUMOylase activity

ubiquitin-like protein peptidase activity [inference]

deSUMOylase activity

ubiquitin-like protein-specific endopeptidase activity [inference]

SUMO-specific endopeptidase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
330				GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
RHOF GTPase cycle	Homo sapiens
SUMO is proteolytically processed	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

International Collaboration

Acknowledgements