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MIRAGE
Extracellular calcium-sensing receptor
Summary
- UniProt ID
- Q9QY96
- Gene Symbol
- Casr Gprc2a
- Gene ID
- 12374
- Organism
- Mus musculus (house mouse)
External Links
- GlycoProtDB
- GPDB0007671
- PubChem
- Q9QY96
- Re-Glyco
- Q9QY96
Annotation
- Keyword
- Alternative splicing Calcium Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Metal-binding Phosphoprotein Reference proteome Signal Transmembrane helix Ubl conjugation
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| ossification | ||
| ossification | ||
| response to ischemia | ||
| detection of calcium ion | ||
| detection of calcium ion |
GO Hierarchy
biological process
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of signaling [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
| GO Term | Evidence Code | Reference |
|---|---|---|
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane |
GO Hierarchy
| GO Term | Evidence Code | Reference |
|---|---|---|
| G protein-coupled receptor activity | ||
| G protein-coupled receptor activity | ||
| G protein-coupled receptor activity | ||
| G protein-coupled receptor activity | ||
| integrin binding |
GO Hierarchy
Sequence
MAWFGYCLALLALTWHSSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINSSPALLPNMTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQQVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGRIWLASEAWASSSLIAMPEYFHVVGGTIGFGLKAGQIPGFREFLQKVHPRKSVHNGFAKEFWEETFNCHLQDGAKGPLPVDTFVRSHEEGGNRLLNSSTAFRPLCTGDENINSVETPYMDYEHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEGKILWSGFSREVPFSNCSRDCQAGTRKGIIEGEPTCCFECVECPDGEYSGETDASACDKCPDDFWSNENHTSCIAKEIEFLAWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICIIWLYTAPPSSYRNHELEDEIIFITCHEGSLMALGSLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKVYIILFKPSRNTIEEVRSSTAAHAFKVAARATLRRPNISRKRSSSLGGSTGSIPSSSISSKSNSEDRFPQPERQKQQQPLALTQQEQQQQPLTLQPQQQQQPQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSMRQNSLEAQKSNDTLNRHQALLPLQCAEADSEMTIQETGLQGPMVGDHQPEIESPDEMSPALVMSTSRSFVISGGGSSVTENILHS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 90 |
|
|
||
| 130 |
|
|
||
| 261 |
|
|
||
| 287 |
|
|
||
| 386 |
|
|
||
| 446 |
|
|
||
| 468 |
|
|
||
| 488 |
|
|
||
| 541 |
|
|
||
| 594 |
|
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Class C/3 (Metabotropic glutamate/pheromone receptors) | Mus musculus |
| G alpha (i) signalling events | Mus musculus |
| G alpha (q) signalling events | Mus musculus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060700 | familial hypocalciuric hypercalcemia 1 | |
| DOID:13543 | hyperparathyroidism | |
| DOID:0090107 | autosomal dominant hypocalcemia 1 |
