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Histamine H3 receptor

Summary

UniProt ID

Q9QYN8

Gene Symbol

Hrh3

Gene ID

[85268]

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: Q9QYN8
Re-Glyco: Q9QYN8

Annotation

Keyword: Alternative splicing Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Phosphoprotein Reference proteome Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	Reference
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA	GO_REF
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	IBA	GO_REF
positive regulation of cytosolic calcium ion concentration	IMP	PMID
chemical synaptic transmission	IBA	GO_REF
learning	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

G protein-coupled acetylcholine receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway [inference]

G protein-coupled acetylcholine receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

cyclic nucleotide metabolic process [inference]

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

cyclic nucleotide metabolic process [inference]

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

cyclic nucleotide metabolic process [inference]

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

cyclic nucleotide metabolic process [inference]

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

carbohydrate derivative metabolic process [inference]

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition

learning or memory [inference]

behavior [inference]

learning or memory [inference]

feeding behavior [inference]

response to stimulus [inference]

response to chemical [inference]

response to lipid [inference]

response to forskolin

response to oxygen-containing compound [inference]

response to alcohol [inference]

response to forskolin

response to ketone [inference]

response to forskolin

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

regulation of fatty acid transport [inference]

regulation of icosanoid secretion [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

regulation of arachidonate secretion [inference]

positive regulation of arachidonic acid secretion

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

regulation of organic acid transport [inference]

regulation of glutamate secretion [inference]

negative regulation of glutamate secretion

regulation of gamma-aminobutyric acid secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of organic acid transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

regulation of fatty acid transport [inference]

regulation of icosanoid secretion [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

regulation of arachidonate secretion [inference]

positive regulation of arachidonic acid secretion

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

regulation of monoatomic ion transport [inference]

regulation of serotonin secretion [inference]

negative regulation of serotonin secretion

negative regulation of monoatomic ion transport [inference]

negative regulation of serotonin secretion

regulation of secretion [inference]

regulation of gamma-aminobutyric acid secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

regulation of icosanoid secretion [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

regulation of arachidonate secretion [inference]

positive regulation of arachidonic acid secretion

positive regulation of secretion [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

negative regulation of secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of secretion by cell [inference]

regulation of secretion by cell [inference]

regulation of glutamate secretion [inference]

negative regulation of glutamate secretion

regulation of serotonin secretion [inference]

negative regulation of serotonin secretion

regulation of catecholamine secretion [inference]

regulation of norepinephrine secretion

negative regulation of secretion by cell [inference]

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

positive regulation of organic acid transport [inference]

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

positive regulation of secretion [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

negative regulation of transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of monoatomic ion transport [inference]

negative regulation of serotonin secretion

negative regulation of secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of secretion by cell [inference]

negative regulation of amine transport [inference]

negative regulation of amino acid transport [inference]

regulation of amine transport [inference]

regulation of catecholamine secretion [inference]

regulation of norepinephrine secretion

negative regulation of amine transport [inference]

negative regulation of amino acid transport [inference]

regulation of amino acid transport [inference]

regulation of glutamate secretion [inference]

negative regulation of glutamate secretion

regulation of gamma-aminobutyric acid secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of amino acid transport [inference]

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

regulation of fatty acid transport [inference]

regulation of icosanoid secretion [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

regulation of arachidonate secretion [inference]

positive regulation of arachidonic acid secretion

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

positive regulation of organic acid transport [inference]

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

positive regulation of secretion [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of secretion by cell [inference]

negative regulation of transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of monoatomic ion transport [inference]

negative regulation of serotonin secretion

negative regulation of secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of secretion by cell [inference]

negative regulation of amine transport [inference]

negative regulation of amino acid transport [inference]

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

G protein-coupled acetylcholine receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway [inference]

G protein-coupled acetylcholine receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation

regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation

negative regulation of cellular process [inference]

negative regulation of secretion by cell [inference]

regulation of secretion by cell [inference]

regulation of glutamate secretion [inference]

negative regulation of glutamate secretion

regulation of serotonin secretion [inference]

negative regulation of serotonin secretion

regulation of catecholamine secretion [inference]

regulation of norepinephrine secretion

negative regulation of secretion by cell [inference]

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

regulation of blood pressure [inference]

negative regulation of blood pressure

Displaying **all 4** entries
GO Term	Evidence Code	Reference
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF
dendrite	IBA	GO_REF
synapse	IBA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

Displaying **all 5** entries
GO Term	Evidence Code	Reference
histamine receptor activity	IBA	GO_REF
histamine receptor activity	IEA	GO_REF
neurotransmitter receptor activity	IBA	GO_REF
amine binding	IPI	PMID
heterocyclic compound binding	IPI	PMID

GO Hierarchy

molecular function

binding [inference]

small molecule binding [inference]

heterocyclic compound binding

amine binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

histamine receptor activity

neurotransmitter receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
11	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Histamine receptors	Rattus norvegicus

Disease

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:11832	visual epilepsy	Alliance of Genome Resources
DOID:4195	hyperglycemia	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:10808	gastric ulcer	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources
DOID:11446	sciatic neuropathy	Alliance of Genome Resources
DOID:10914	amnestic disorder	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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External Links

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International Collaboration

Acknowledgements