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Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3

Summary

UniProt ID: Q9R0E1
Gene Symbol: Plod3
Gene ID: 26433
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB

GPDB0007703

GlyConnect

Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

GlyGen

Q9R0E1

PubChem

Q9R0E1

Re-Glyco

Q9R0E1

Annotation

Keyword: Dioxygenase Disulfide bond Endoplasmic reticulum Glycoprotein Glycosyltransferase Iron Manganese Membrane Metal-binding Multifunctional enzyme Reference proteome Secreted Signal Vitamin C

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
in utero embryonic development	IMP	PMID
endothelial cell morphogenesis	IMP	PMID
protein O-linked glycosylation	ISO	GO_REF
protein localization	IMP	PMID
intracellular protein localization	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via galactose

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via galactose

collagen metabolic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via galactose

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via galactose

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

macromolecule modification [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via galactose

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via galactose

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via galactose

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

extracellular matrix assembly [inference]

basement membrane assembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

basement membrane organization [inference]

basement membrane assembly

extracellular matrix assembly [inference]

basement membrane assembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

basement membrane organization [inference]

basement membrane assembly

extracellular matrix assembly [inference]

basement membrane assembly

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasodilation

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis [inference]

epithelial cell morphogenesis [inference]

endothelial cell morphogenesis

animal organ morphogenesis [inference]

lung morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

epidermis morphogenesis

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

animal gross anatomical part developmental process [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

tissue development [inference]

epithelium development [inference]

neural tube development

tube development [inference]

neural tube development

localization [inference]

macromolecule localization [inference]

intracellular protein localization

biological regulation [inference]

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasodilation

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	Reference
obsolete extracellular space
endoplasmic reticulum	ISO	GO_REF
endoplasmic reticulum	IDA	PMID
endoplasmic reticulum	IBA	GO_REF
endoplasmic reticulum	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

external encapsulating structure [inference]

extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

rough endoplasmic reticulum

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

rough endoplasmic reticulum

Golgi apparatus

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	Reference
iron ion binding	ISO	GO_REF
iron ion binding	IEA	GO_REF
procollagen-lysine 5-dioxygenase activity	ISO	GO_REF GO_REF
procollagen-lysine 5-dioxygenase activity	IDA	PMID PMID
procollagen-lysine 5-dioxygenase activity	IBA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

procollagen-lysine 5-dioxygenase activity

dioxygenase activity [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

procollagen-lysine 5-dioxygenase activity

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

UDP-galactosyltransferase activity [inference]

procollagen galactosyltransferase activity

hexosyltransferase activity [inference]

galactosyltransferase activity [inference]

UDP-galactosyltransferase activity [inference]

procollagen galactosyltransferase activity

glucosyltransferase activity [inference]

procollagen glucosyltransferase activity

catalytic activity, acting on a protein [inference]

binding [inference]

carbohydrate binding [inference]

monosaccharide binding [inference]

L-ascorbic acid binding

small molecule binding

vitamin binding [inference]

L-ascorbic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

iron ion binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

monosaccharide binding [inference]

L-ascorbic acid binding

heterocyclic compound binding [inference]

L-ascorbic acid binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MAAAGPEPRLLLLLLLLLPPLPPVTSASDRPRGANAVNPDKLLVITVATAETEGYRRFLQSAEFFNYTVRTLGLGQEWRGGDVARTVGGGQKVRWLKKEMEKYADQKDMIIMFVDSYDVILASSPTELLKKFVQSGSHLLFSAESFCWPEWGLAEQYPEVGMGKRFLNSGGFIGFAPTIHQIVRQWNYKDDDDDQLFYTQLYLDPGLREKLKLSLDHKSRIFQNLNGALDEVILKFDQNRVRIRNVAYDTLPVVVHGNGPTKLQLNYLGNYVPNGWTPQGGCGFCNQTLRTLPGGQPPPRVLLAVFVEQPTPFLPRFLQRLLLLDYPPDRISLFLHNSEVYHEPHIADAWPQLQDHFSAVKLVGPEEALSAGEARDMAMDSCRQNPECEFYFSLDADAVLTNPETLRVLIEQNRKVIAPMLSRHGKLWSNFWGALSPNEYYARSEDYVELVQRKRVGVWNVPYISQAYVIRGETLRTELPQKEVFSSSDTDPDMAFCKSVRDKGIFLHLSNQHEFGRLLATSRYDTDHLHPDLWQIFDNPVDWREQYIHENYSRALDGEGLVEQPCPDVYWFPLLTEQMCDELVEEMEHYGQWSGGRHEDSRLAGGYENVPTVDIHMKQVGYEDQWLQLLRTYVGPMTEYLFPGYHTKTRAVMNFVVRYRPDEQPSLRPHHDSSTFTLNVALNHKGVDYEGGGCRFLRYDCRISSPRKGWALLHPGRLTHYHEGLPTTRGTRYIMVSFVDP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
66	N-linked (GlcNAc...) asparagine	19349973 30899004	G64527OM G39188ZX G41247ZX	GlycoProtDB UniProt GlyGen GlyConnect
286	N-linked (GlcNAc...) asparagine			UniProt GlyGen
551	N-linked (GlcNAc...) asparagine	30899004	G70101JE G64527OM G05724UK G39188ZX G92050GC	GlycoProtDB UniProt GlyGen GlyConnect