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Sodium bicarbonate cotransporter 3

Summary

UniProt ID: Q9R1N3
Gene Symbol: Nbc Nbc2 Nbc3 Nbcn1 Slc4a7
Gene ID: 117955
Organism: Rattus norvegicus (Norway rat)

External Links

Re-Glyco: Q9R1N3

Annotation

Keyword: Alternative splicing Cell membrane Cell projection Disulfide bond Glycoprotein Phosphoprotein Reference proteome Sodium transport Symport Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	Reference
purine nucleotide biosynthetic process	ISO	GO_REF
pyrimidine nucleotide biosynthetic process	ISO	GO_REF
visual perception	ISO	GO_REF
sensory perception of sound	ISO	GO_REF
bicarbonate transport	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

pyrimidine nucleotide metabolic process [inference]

pyrimidine nucleotide biosynthetic process

nucleotide biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

pyrimidine nucleotide metabolic process [inference]

pyrimidine nucleotide biosynthetic process

nucleotide biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleotide biosynthetic process

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

pyrimidine nucleotide metabolic process [inference]

pyrimidine nucleotide biosynthetic process

nucleotide biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

pyrimidine nucleotide metabolic process [inference]

pyrimidine nucleotide biosynthetic process

nucleotide biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleotide metabolic process [inference]

pyrimidine nucleotide biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleotide biosynthetic process

cell death [inference]

programmed cell death [inference]

programmed cell death involved in cell development [inference]

retinal cell programmed cell death

cellular developmental process [inference]

programmed cell death involved in cell development [inference]

retinal cell programmed cell death

cell differentiation [inference]

neuron differentiation [inference]

photoreceptor cell differentiation [inference]

eye photoreceptor cell differentiation [inference]

camera-type eye photoreceptor cell differentiation

cell development [inference]

neuron development [inference]

inner ear receptor cell development [inference]

auditory receptor cell development

transmembrane transport

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

sensory perception of mechanical stimulus [inference]

sensory perception of sound

behavior [inference]

locomotory behavior [inference]

locomotory exploration behavior

exploration behavior [inference]

locomotory exploration behavior

developmental process [inference]

anatomical structure morphogenesis [inference]

retina vasculature morphogenesis in camera-type eye

anatomical structure development [inference]

cell development [inference]

neuron development [inference]

inner ear receptor cell development [inference]

auditory receptor cell development

neural nucleus development [inference]

cochlear nucleus development

cellular developmental process [inference]

programmed cell death involved in cell development [inference]

retinal cell programmed cell death

cell differentiation [inference]

neuron differentiation [inference]

photoreceptor cell differentiation [inference]

eye photoreceptor cell differentiation [inference]

camera-type eye photoreceptor cell differentiation

cell development [inference]

neuron development [inference]

inner ear receptor cell development [inference]

auditory receptor cell development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH

intracellular pH reduction [inference]

phagosome acidification

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH

intracellular pH reduction [inference]

phagosome acidification

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of intracellular pH

intracellular pH reduction [inference]

phagosome acidification

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH

intracellular pH reduction [inference]

phagosome acidification

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH

intracellular pH reduction [inference]

phagosome acidification

response to stimulus [inference]

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

organic anion transport [inference]

bicarbonate transport

transmembrane transport

biological regulation [inference]

regulation of pH [inference]

regulation of intracellular pH

intracellular pH reduction [inference]

phagosome acidification

regulation of biological quality [inference]

regulation of intracellular pH

intracellular pH reduction [inference]

phagosome acidification

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	Reference
cytoplasm	ISO	GO_REF
plasma membrane	ISO	GO_REF
plasma membrane	EXP	PMID
plasma membrane	IDA	PMID
plasma membrane	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

membrane

plasma membrane

plasma membrane region [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

stereocilium

actin-based cell projection [inference]

stereocilium

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
solute:inorganic anion antiporter activity	IEA	GO_REF
monoatomic anion transmembrane transporter activity	IEA	GO_REF
sodium:bicarbonate symporter activity	ISO	GO_REF
sodium:bicarbonate symporter activity	EXP	PMID PMID
sodium:bicarbonate symporter activity	IDA	PMID PMID PMID PMID PMID

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

sodium:bicarbonate symporter activity

monoatomic cation:bicarbonate symporter activity [inference]

sodium:bicarbonate symporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

sodium:bicarbonate symporter activity

monoatomic anion transmembrane transporter activity

bicarbonate transmembrane transporter activity [inference]

monoatomic cation:bicarbonate symporter activity [inference]

sodium:bicarbonate symporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

sodium:bicarbonate symporter activity

monoatomic cation:bicarbonate symporter activity [inference]

sodium:bicarbonate symporter activity

antiporter activity [inference]

solute:inorganic anion antiporter activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MEADGAGEQMRPLLTRGPDEEAVVDLGKTSSTVNTKFEKEELESHRAVYVGVHVPFSKESRRRHRHRGHKHHHRRRKDKDSDKEDGRESPSYDTPSQRVQFILGTEDDDEEHIPHDLFTEMDELCYRDGEEYEWKETARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRASTLDEIADMVLDNMIASGQLDDSIRENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKKHSDPHLLERNGEGLSASRHSLRTGLSASNLSLRGESPLSLLLSHLLPSSRAGTPAGSRCTTPVPTPQNSPPSSPSLSRLTSRSSQQTQPQAPEVLVSPDRDDIPRVVIHPPEEDIEALKGQEQKNEENTDFTPGILASPQSAPGNLDSSKSGEVKGNGSGGSRENSTVDFSKVDMNFMRKIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLSGLTEVPVPTRFLFLLLGPAGKAPQYHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEPPKSVPSQEKRKIPAFPNGSAPVSADPPKEADHHAGPELQRTGRLFGGLILDIKRKAPFFLSDFKDALSLQCLASILFLYCACMSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKILFKFCRDYHLSYLSLRTSIGLWTSFLCIVLVATDASSLVCYITRFTEEAFAALICIIFIYEALEKLFHLGEIYAFNMHNNLDALTSYTCVCAEPSNPSNETVELWERKNVTAASISWANLTVSECKTFHGMFVGSACGPHGPYVPDVLFWCVVLFFTTFFLSSFLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVAIDYLVGIPSPKLHVPEKFEPTDPSRGWIISPLGDNPWWTLLIAAVPALLCTILIFMDQQITAVIINRKEHKLKKGAGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSISHVNSLKVESECSAPGEQPKFLGIREQRVTGLMIFILMGLSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQFFDRIKLFGMPAKHQPDLIYLRYVPLWKVHVFTVVQLTCLVLLWVIKASAAAVVFPMMVLALVFVRKLMDLCFTKRELSWLDDLMPESKKKKEDDKKKKEKEEAERMLQGDGDTVHLPFERGSLLQIPVKTLKYSPEKPVSVTINFEDEPSKKYMDAETSL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	Source
176	N-linked (GlcNAc...) asparagine	UniProt
274	N-linked (GlcNAc...) asparagine	UniProt
410	N-linked (GlcNAc...) asparagine	UniProt
780	N-linked (GlcNAc...) asparagine	UniProt
790	N-linked (GlcNAc...) asparagine	UniProt
800	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Bicarbonate transporters	Rattus norvegicus
RHOF GTPase cycle	Rattus norvegicus
RHOH GTPase cycle	Rattus norvegicus
RHOQ GTPase cycle	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

International Collaboration

Acknowledgements