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Acid-sensing ion channel 3

Summary

UniProt ID: Q9UHC3
Gene Symbol: ACCN3 ASIC3 DRASIC SLNAC1 TNAC1
Gene ID: 9311
Organism: Homo sapiens (human)

External Links

GlyGen: Q9UHC3
PubChem: Q9UHC3
The Human Metabolome Database: HMDBP09054
Re-Glyco: Q9UHC3

Annotation

Keyword: Alternative splicing Cell membrane Cytoplasm Disulfide bond Glycoprotein Phosphoprotein Reference proteome Sodium channel Transmembrane helix

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
response to heat
response to acidic pH
sodium ion transmembrane transport	IBA	GO_REF
sodium ion transmembrane transport	IEA	GO_REF
sensory perception of sour taste	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of chemical stimulus [inference]

sensory perception of taste [inference]

sensory perception of sour taste

response to stimulus [inference]

response to stress [inference]

response to heat

response to external stimulus [inference]

detection of external stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to heat

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

response to pH [inference]

response to acidic pH

detection of abiotic stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of stimulus [inference]

detection of external stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of abiotic stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of chemical stimulus [inference]

detection of chemical stimulus involved in sensory perception [inference]

detection of chemical stimulus involved in sensory perception of pain

detection of stimulus involved in sensory perception [inference]

detection of chemical stimulus involved in sensory perception [inference]

detection of chemical stimulus involved in sensory perception of pain

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport [inference]

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

establishment of localization in cell

biological regulation [inference]

regulation of biological quality [inference]

regulation of membrane potential [inference]

membrane depolarization

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GO Term	Evidence Code	Reference
cytoplasm	ISS	GO_REF
cytoplasm	IEA	GO_REF
plasma membrane	EXP	PMID
plasma membrane	TAS	PMID Reactome Reactome Reactome Reactome
plasma membrane	IDA	PMID PMID PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

membrane [inference]

plasma membrane

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GO Term	Evidence Code	Reference
sodium channel activity	TAS	PMID
sodium channel activity	IEA	GO_REF
ligand-gated sodium channel activity	IBA	GO_REF
ligand-gated sodium channel activity	IEA	GO_REF
monoatomic ion-gated channel activity	IEA	GO_REF

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity

ligand-gated sodium channel activity

pH-gated sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

pH-gated sodium channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

pH-gated sodium channel activity

pH-gated monoatomic ion channel activity

pH-gated sodium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity

ligand-gated sodium channel activity

pH-gated sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

pH-gated sodium channel activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity

ligand-gated sodium channel activity

pH-gated sodium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity

ligand-gated sodium channel activity

pH-gated sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

pH-gated sodium channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

pH-gated sodium channel activity

pH-gated monoatomic ion channel activity

pH-gated sodium channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

pH-gated sodium channel activity

pH-gated monoatomic ion channel activity

pH-gated sodium channel activity

monoatomic ion-gated channel activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MKPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAEHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFTRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLRKDSCACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQRHSSTNLLQEGLGSHRTQVPHLSLGPRPPTPPCAVTKTLSASHRTCYLVTQL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	Source
175	N-linked (GlcNAc...) asparagine	UniProt GlyGen
398	N-linked (GlcNAc...) asparagine	UniProt GlyGen
509		GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Stimuli-sensing channels	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

Annotation

International Collaboration

Acknowledgements