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NPC intracellular cholesterol transporter 1 homolog 1b

Summary

UniProt ID: Q9VRC9
Gene Symbol: CG12092 Npc1b
Gene ID: 33072
Organism: Drosophila melanogaster (fruit fly)

External Links

Re-Glyco: Q9VRC9

Annotation

Keyword: Cell membrane Cholesterol metabolism Disulfide bond Glycoprotein Lipid transport Reference proteome Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
dorsal closure	IMP	PMID
central nervous system development	IMP	PMID
peripheral nervous system development	IMP	PMID
cholesterol metabolic process
sterol transport	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

morphogenesis of embryonic epithelium [inference]

dorsal closure

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of embryonic epithelium [inference]

dorsal closure

anatomical structure development [inference]

system development [inference]

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

lipid transport [inference]

sterol transport

cholesterol transport

organic hydroxy compound transport [inference]

sterol transport

cholesterol transport

Displaying **all 3** entries
GO Term	Evidence Code	Reference
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF
membrane	ISM	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	Reference
lipid carrier activity	NAS	PMID
cholesterol binding	IBA	GO_REF

GO Hierarchy

molecular function

binding [inference]

lipid binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

small molecule binding [inference]

alcohol binding [inference]

cholesterol binding

molecular carrier activity [inference]

lipid carrier activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MKVIFATIWLIAGAWSQSAEQLGCIWYGQSHMIGAHWVNKGDTNPARPLNSPTSEAIFAKRCPMLYKEYKGESGEDELSLCCDAAQIETMESGLSQADGVFSRCPTCTRNMALTVCAMTCAKNHTLFLTAYNDTNDAGVDYVKYIDYRLTDDTVSKIYNSCIGIQHTQTGRPAMDLGCGSYNAKTCNYRRWYEFMGDVSGDYVPFQINYKWSEDAEEGSNEIYLDLSPLKCGESYEDSYACACIDCEESCPLTDAPTGPDELWKIAGLYGVTFILALIIACALSFFIFWGAFGKTSAPSVCMPTLFGEFFYHGFRIWGTFCAKHPVIVLALCSWAIAGLSFGIRYMTITTDPVELWAGEESQTRIEKDYFDQHFGPFYRTNQMFVKAVNQTYFTHETSNGVLNFGPAFEYNFLKEVFELQDSIMKLGMADNEGLDKICYAPVLMAGETPTVDRCAIQSVYGYFQHDMDRFENSYVDSNNYTINYLNQLEDCLRVPMMEDCFGTFGGPIEPGIAVGGMPKVAVGEDPDYMLATGLVLTFLGRNYNDESKLEPNMKWEKLFVDFLRDYKSDRLDIAYMAERSIQDAIVELSEGEVSTVVISYVVMFVYVAIALGHIRSCRGFLRESRIMLAIGGIVIVLASVVCSLGFWGYLDVTTTMLAIEVIPFLVLAVGVDNIFIMVHTYQRLDHSKFKTTHEAIGEAIGQVGPSILQTAGSEMACFAIGCISDMPAVKTFAMYAAIAILLDFLLQITAFVALMAIDEKRYLDGRLDMLCCVKSGGKKINDEDGDGVDRPKEVGLLETLFKNFYSPFLLSKPVKVSVLLIFTVITCLSLMVTPSIEKGLDQEMSMPKNSHVVKYFRYMVDLLAMGAPVYWVLKPGLNYSEPLQQNLICGGVECNNNSLSVQLYTQAQYPEITSLARPASSWLDDYIDWLAISDCCKYNVTTGGFCSSNSKSEDCLPCERGFTENGLRPDAETFNKYIPYFLFDLPDAECAKAGRASYADAVIYTIDDVGMSTVQDSYFMQYSTTSTTSEEFYSQLREVRRISGEINAMFKENNVDAEIFAYCVFYIYYEQYLTIWGDAMFSLGMSLVAIFLVTLLITGLDITSTFIVLFMVICILINMLGMMWAWSINLNAISLVNLVVCVGIGVEFVAHIVRSFKRAEGTAQERARHSLNVTGSSVLSGITLTKFAGIVVLGFSNSQIFQVFYFRMYLGIVLIGAAHGLILLPVLLSLLGPPQKLARSSGAEPTASITITTN

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	Source
123	N-linked (GlcNAc...) asparagine	UniProt
132	N-linked (GlcNAc...) asparagine	UniProt
389	N-linked (GlcNAc...) asparagine	UniProt
479	N-linked (GlcNAc...) asparagine	UniProt
896	N-linked (GlcNAc...) asparagine	UniProt
939	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Intestinal lipid absorption	Drosophila melanogaster

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

International Collaboration

Acknowledgements