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Frizzled-2

Summary

UniProt ID: Q9VVX3
Gene Symbol: 2 CG9739 D-Fz2 D-fz2 DFZ2 DFz-2 DFz2 DFz2C Dfrz2 Dfz2 Dfz[[2]] Dm Dmel\CG9739 Dmel_CG9739 FZ2 Frizzled Fz2 Fz2R dFz2 dfz(2) dfz2 dfz2r frz2 fz-2 fz2
Gene ID: 40090
Organism: Drosophila melanogaster (fruit fly)

External Links

PubChem: Q9VVX3
Re-Glyco: Q9VVX3

Annotation

Keyword: Cell membrane Developmental protein Disulfide bond G-protein coupled receptor Glycoprotein Reference proteome Signal Transmembrane helix Wnt signaling pathway

Gene Ontology (GO)

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	Reference
segment polarity determination	IGI	PMID PMID PMID PMID
salivary gland morphogenesis	IMP	PMID
midgut development	IGI	PMID
motor neuron axon guidance	IMP	PMID
female gonad development	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

non-canonical Wnt signaling pathway

Frizzled Nuclear Import pathway

canonical Wnt signaling pathway

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

cellular developmental process [inference]

cell fate specification [inference]

neuron fate specification

cardiac cell fate specification [inference]

cardioblast cell fate specification

cell motility [inference]

cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance [inference]

cell junction organization [inference]

synapse organization

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

female gonad development

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

periodic partitioning [inference]

segment polarity determination

cuticle pattern formation [inference]

chitin-based larval cuticle pattern formation

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

germ-line stem-cell niche homeostasis

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

female gonad development

anatomical structure morphogenesis [inference]

post-embryonic animal morphogenesis [inference]

imaginal disc-derived wing margin morphogenesis

animal organ morphogenesis [inference]

gland morphogenesis [inference]

salivary gland morphogenesis

anatomical structure development [inference]

tube development [inference]

digestive tract development [inference]

midgut development

animal organ development [inference]

gonad development [inference]

female gonad development

reproductive structure development [inference]

gonad development [inference]

female gonad development

cellular developmental process [inference]

cell fate specification [inference]

neuron fate specification

cardiac cell fate specification [inference]

cardioblast cell fate specification

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

developmental growth involved in morphogenesis [inference]

neuron projection extension [inference]

axon extension

locomotion [inference]

taxis [inference]

chemotaxis [inference]

negative chemotaxis [inference]

synaptic target inhibition

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

germ-line stem-cell niche homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of hemocyte proliferation

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of axonogenesis

regulation of hemocyte proliferation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

non-canonical Wnt signaling pathway

Frizzled Nuclear Import pathway

canonical Wnt signaling pathway

regulation of cell population proliferation [inference]

regulation of hemocyte proliferation

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of axonogenesis

regulation of multicellular organismal process [inference]

regulation of hemocyte proliferation

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
nucleus	IDA	PMID
plasma membrane	TAS	Reactome Reactome Reactome Reactome Reactome Reactome Reactome
plasma membrane	IDA	PMID PMID PMID
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

Wnt-Frizzled-LRP5/6 complex

Wnt signalosome

cellular anatomical structure [inference]

membrane

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
G protein-coupled receptor activity
Wnt-protein binding	IDA	PMID
Wnt-protein binding	IBA	GO_REF
Wnt-protein binding	IPI	PMID PMID PMID
PDZ domain binding	IPI	PMID

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

Wnt-protein binding

protein domain specific binding [inference]

PDZ domain binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MRHNRLKVLILGLVLLLTSCRADGPLHSADHGMGGMGMGGHGLDASPAPGYGVPVIPKDPNLRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGPFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACDGLLLRESSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDWIKALACPCAQVKGPGKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRLLGAPDRTGANQALIKQRPPIPHPYAGSGMGMPVGSAAGSLLATPYTQAGGASVASTSHHHLHHHVLKQPAASHV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
78	N-linked (GlcNAc...) asparagine			UniProt
288	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
Assembly of receptor complex	Drosophila melanogaster
Asymmetric localization of PCP proteins	Drosophila melanogaster
Phosphorylation of ARR	Drosophila melanogaster
Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM	Drosophila melanogaster
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	Drosophila melanogaster

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements