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Chloride anion exchanger

Summary

UniProt ID: Q9WVC8
Gene Symbol: Slc26a3 Dra
Gene ID: 13487
Organism: Mus musculus (house mouse)

External Links

PubChem: Q9WVC8
Re-Glyco: Q9WVC8

Annotation

Keyword: 3D-structure Antiport Cell membrane Chloride Glycoprotein Reference proteome Transmembrane helix

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
sperm capacitation	IMP	PMID
intracellular pH elevation	IMP	PMID
membrane hyperpolarization	IMP	PMID
cellular response to cAMP	IDA	PMID
sulfate transmembrane transport	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

cellular process involved in reproduction in multicellular organism [inference]

sperm capacitation

cellular developmental process [inference]

cell maturation [inference]

sperm capacitation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

sulfate transmembrane transport

reproductive process [inference]

developmental process involved in reproduction [inference]

sperm capacitation

multicellular organismal reproductive process [inference]

cellular process involved in reproduction in multicellular organism [inference]

sperm capacitation

developmental process [inference]

developmental process involved in reproduction [inference]

sperm capacitation

developmental maturation [inference]

anatomical structure maturation [inference]

cell maturation [inference]

sperm capacitation

cellular developmental process [inference]

cell maturation [inference]

sperm capacitation

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH elevation

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH elevation

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of intracellular pH [inference]

intracellular pH elevation

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH elevation

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH elevation

response to stimulus [inference]

response to chemical [inference]

response to organophosphorus [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

response to nitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to nitrogen compound [inference]

cellular response to cAMP

response to oxygen-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

sulfate transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

sulfate transmembrane transport

sulfur compound transport [inference]

sulfate transmembrane transport

biological regulation [inference]

regulation of pH [inference]

regulation of intracellular pH [inference]

intracellular pH elevation

regulation of biological quality [inference]

regulation of membrane potential [inference]

membrane hyperpolarization

regulation of intracellular pH [inference]

intracellular pH elevation

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GO Term	Evidence Code	Reference
plasma membrane	ISS	PMID GO_REF
plasma membrane	ISO	GO_REF
plasma membrane	IEA	GO_REF GO_REF
membrane	IDA	PMID
membrane	IEA	GO_REF GO_REF GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

brush border membrane

sperm midpiece

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
secondary active sulfate transmembrane transporter activity	IEA	GO_REF
bicarbonate transmembrane transporter activity	IMP	PMID
chloride transmembrane transporter activity	IMP	PMID
sulfate transmembrane transporter activity	IBA	GO_REF
oxalate transmembrane transporter activity	IBA	GO_REF

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity

chloride:bicarbonate antiporter activity

bicarbonate:monoatomic anion antiporter activity [inference]

chloride:bicarbonate antiporter activity

bicarbonate transmembrane transporter activity

bicarbonate:monoatomic anion antiporter activity [inference]

chloride:bicarbonate antiporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

secondary active sulfate transmembrane transporter activity

antiporter activity [inference]

solute:inorganic anion antiporter activity [inference]

chloride:bicarbonate antiporter activity

bicarbonate:monoatomic anion antiporter activity [inference]

chloride:bicarbonate antiporter activity

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

oxalate transmembrane transporter activity

sulfur compound transmembrane transporter activity [inference]

sulfate transmembrane transporter activity

secondary active sulfate transmembrane transporter activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MIEAIGNQYVVARPVYSTKTFGEEFKKTHRHHKTFLDHLKGCCSCSSQKAKKIALSLFPIASWLPAYKIKEWLLSDIVSGISTGLVAVLQGLAFALLVNIPPAYGLYAAFFPVITYFFLGTSRHISVGPFPVLSMMVGVVVTRVVSDPNASSELSSSSTENDSFIEEKVMVAASVTVLSGIIQLLLGVLQVGFVVIYLSESLISGFTTAAAIHVLVSQLKFMLQLPVPAYSDPFSIFKVLESVFTQIQKTNIADLVTSVIILVVVFVFKEINQRYRSKLPVPIPIELIMTVIATGVSYGCNFEDRFGVAVVGNMSLGFQPPITPSVEVFQDTIGDSFGIAIVGFAVAFSVASVYSLKYDYPIDGNQELIALGVSNIFTGAFKGFAGSTALSRSGVQESTGGKTQVAGLLSAVIVLIVIVAIGFLLQPLQKSVLAALALGNLKGMLMQFAEIGRLWKKDKYDCLIWIMTFIFAIVLGLGLGLAASVAFQLLTIVFRTQFPKCSTLANVGRSNIYKNKKNYAEVYEPEGVKIFRCPSPIYFANIGFFKQKLIDAVGFSPLRILRKRNKALKKIRKLQKRGLIQMTPKGFICTSDGFKDSDEELDNNQIEELDQPINTTDLPFDIDWNGDLPLNITIPKISLHSLILDFSAVSFLDVSSMRGLRTILQEFIRIKVDVYIVGTDDDFIDKLARCEFFDDEVTDSIFFLTIHDAILHILMKKDYSTSKFNSSQEKERKFDFTINTNGGLRNRECQVPVETKF

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
149	N-linked (GlcNAc...) asparagine			UniProt
161	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Inorganic anion exchange by SLC26 transporters	Mus musculus

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060296	congenital secretory chloride diarrhea 1	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Acknowledgements