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Protein kinase C and casein kinase substrate in neurons protein 2

Summary

UniProt ID: Q9WVE8
Gene Symbol: Pacsin2
Gene ID: 23970
Organism: Mus musculus (house mouse)

External Links

GlyGen: Q9WVE8
PubChem: Q9WVE8
Re-Glyco: Q9WVE8

Annotation

Keyword: 3D-structure Acetylation Cell junction Cell membrane Cell projection Coiled coil Cytoplasmic vesicle Cytoskeleton Endocytosis Endosome Lipid-binding Phosphoprotein Reference proteome SH3 domain

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
cell migration involved in sprouting angiogenesis	IDA	PMID
cytoskeleton organization	IBA	GO_REF
signal transduction	TAS	PMID
actin cytoskeleton organization	IEA	GO_REF
regulation of endocytosis	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

signal transduction

vesicle-mediated transport [inference]

endocytosis [inference]

caveolin-mediated endocytosis

actin filament-based process [inference]

actin cytoskeleton organization

cell motility [inference]

cell migration [inference]

endothelial cell migration [inference]

blood vessel endothelial cell migration [inference]

cell migration involved in sprouting angiogenesis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

actin cytoskeleton organization

cellular component assembly [inference]

membrane assembly [inference]

membrane raft assembly [inference]

plasma membrane raft assembly [inference]

caveola assembly

cell projection organization [inference]

cell projection morphogenesis

membrane organization [inference]

plasma membrane organization [inference]

plasma membrane tubulation

membrane raft organization [inference]

membrane raft assembly [inference]

plasma membrane raft assembly [inference]

caveola assembly

plasma membrane raft organization [inference]

plasma membrane raft assembly [inference]

caveola assembly

membrane assembly [inference]

membrane raft assembly [inference]

plasma membrane raft assembly [inference]

caveola assembly

developmental process [inference]

anatomical structure morphogenesis [inference]

cell projection morphogenesis

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to organelle [inference]

protein localization to endosome

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

caveolin-mediated endocytosis

import into cell [inference]

endocytosis [inference]

caveolin-mediated endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

negative regulation of transport [inference]

negative regulation of endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis

negative regulation of endocytosis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of endocytosis

negative regulation of transport [inference]

negative regulation of endocytosis

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of endocytosis

regulation of cellular component organization [inference]

regulation of endocytosis

negative regulation of endocytosis

negative regulation of cellular component organization [inference]

negative regulation of endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis

negative regulation of endocytosis

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GO Term	Evidence Code	Reference
cytoplasm	ISO	GO_REF
cytoplasm	IDA	PMID
cytoplasm	IBA	GO_REF
cytoplasm	IEA	GO_REF
endosome	IBA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

recycling endosome membrane

bounding membrane of organelle [inference]

endosome membrane [inference]

recycling endosome membrane

plasma membrane region [inference]

cell projection membrane [inference]

ruffle membrane

plasma membrane raft [inference]

caveola

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft [inference]

caveola

cell junction [inference]

synapse [inference]

glutamatergic synapse

anchoring junction [inference]

cell-cell junction

adherens junction

leading edge membrane [inference]

ruffle membrane

centriolar satellite

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

early endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

early endosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nuclear body [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

ribonucleoprotein granule [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

early endosome

intracellular membraneless organelle [inference]

nuclear body [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

ribonucleoprotein granule [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

supramolecular complex [inference]

ribonucleoprotein granule [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

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GO Term	Evidence Code	Reference
phospholipid binding	IBA	GO_REF
cytoskeletal protein binding	IDA	PMID
lipid binding	IDA	PMID
lipid binding	IEA	GO_REF
protein-macromolecule adaptor activity	IDA	PMID

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

lipid binding

phospholipid binding

phosphatidic acid binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

phosphatidic acid binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MSVTYDDSVGVEVSSDSFWEVGNYKRTVKRIDDGHRLCGDLMNCLHERARIEKAYAQQLTEWARRWRQLVEKGPQYGTVEKAWIAVMSEAERVSELHLEVKASLMNEDFEKIKNWQKEAFHKQMMGGFKETKEAEDGFRKAQKPWAKKLKEVEAAKKAHHTACKEEKLAISREANSKADPSLNPEQLKKLQDKIEKCKQDVLKTKDKYEKSLKELDQTTPQYMENMEQVFEQCQQFEEKRLRFFREVLLEVQKHLDLSNVASYKTIYRELEQSIKAADAVEDLRWFRANHGPGMAMNWPQFEEWSADLNRTLSRREKKKAVDGVTLTGINQTGDQSGQNKPGSNLSVPSNPAQSTQLQSSYNPFEDEDDTGSSISEKEDIKAKNVSSYEKTQTYPTDWSDDESNNPFSSTDANGDSNPFDEDTTSGTEVRVRALYDYEGQEHDELSFKAGDELTKIEDEDEQGWCKGRLDSGQVGLYPANYVEAIQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites