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Endothelial lipase

Summary

UniProt ID: Q9Y5X9
Gene Symbol: LIPG UNQ387/PRO719
Gene ID: 9388
Organism: Homo sapiens (human)

External Links

GlycoProtDB

GPDB0012698

GlyGen

Q9Y5X9

PubChem

Q9Y5X9

SwissLipids

SLP:000000567

The Human Metabolome Database

HMDBP00239

RaftProt

Q9Y5X9

Re-Glyco

Q9Y5X9

Annotation

Keyword: Alternative splicing Disulfide bond Glycoprotein Heparin-binding Hydrolase Lipid degradation Proteomics identification Reference proteome Secreted Signal

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	Reference
lipid metabolic process	TAS	PMID PMID
lipid metabolic process	IEA	GO_REF
fatty acid biosynthetic process	IBA	GO_REF
response to nutrient	IEA	GO_REF
phospholipid catabolic process	NAS	PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

catabolic process [inference]

lipid catabolic process [inference]

phospholipid catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

primary metabolic process [inference]

lipid metabolic process

fatty acid metabolic process [inference]

fatty acid biosynthetic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

phospholipid metabolic process [inference]

phospholipid catabolic process

lipid biosynthetic process [inference]

fatty acid biosynthetic process

lipid catabolic process [inference]

phospholipid catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-containing complex remodeling [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

protein-lipid complex organization [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

multicellular organismal process [inference]

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

phospholipid homeostasis

sterol homeostasis [inference]

cholesterol homeostasis

response to stimulus [inference]

response to nutrient levels [inference]

response to nutrient

response to chemical [inference]

response to nutrient

localization [inference]

establishment of localization [inference]

transport [inference]

lipid transport [inference]

sterol transport [inference]

cholesterol transport [inference]

reverse cholesterol transport

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport [inference]

reverse cholesterol transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

regulation of cholesterol transport [inference]

positive regulation of cholesterol transport

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

regulation of cholesterol transport [inference]

positive regulation of cholesterol transport

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

positive regulation of biological process [inference]

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

positive regulation of multicellular organismal process [inference]

positive regulation of lipoprotein particle clearance [inference]

positive regulation of high-density lipoprotein particle clearance

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of lipoprotein metabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of lipoprotein metabolic process

regulation of multicellular organismal process [inference]

regulation of lipoprotein particle clearance [inference]

regulation of high-density lipoprotein particle clearance [inference]

positive regulation of high-density lipoprotein particle clearance

positive regulation of lipoprotein particle clearance [inference]

positive regulation of high-density lipoprotein particle clearance

positive regulation of multicellular organismal process [inference]

positive regulation of lipoprotein particle clearance [inference]

positive regulation of high-density lipoprotein particle clearance

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
extracellular region	EXP	PMID
extracellular region	TAS	Reactome
extracellular region	IDA	PMID
extracellular region	IEA	GO_REF GO_REF
obsolete extracellular space

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
lipoprotein lipase activity	IBA	GO_REF
lipoprotein lipase activity	IEA	GO_REF
glycerophospholipase activity	IDA	PMID
glycerophospholipase activity	IEA	GO_REF
triacylglycerol lipase activity	EXP	PMID PMID

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

triacylglycerol lipase activity

lipoprotein lipase activity

phospholipase activity [inference]

glycerophospholipase activity

A1-type glycerophospholipase activity [inference]

glycerophospholipid phospholipase A1 activity

carboxylic ester hydrolase activity [inference]

triacylglycerol lipase activity

lipoprotein lipase activity

A1-type glycerophospholipase activity [inference]

glycerophospholipid phospholipase A1 activity

binding [inference]

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGASQSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWFRKCRDGWRMKNETSPTVELP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 9** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
40		23584533	G57321FI	GlyGen
41		25813380	G57321FI	GlyGen
80	N-linked (GlcNAc...) asparagine			GlycoProtDB UniProt GlyGen
136	N-linked (GlcNAc...) asparagine			UniProt GlyGen
393	N-linked (GlcNAc...) asparagine	16335952 37074911	G49642SA G00912UN G18647XP G85269DF G02815KT	UniProt GlyGen
469	N-linked (GlcNAc...) asparagine			UniProt GlyGen
491	N-linked (GlcNAc...) asparagine			UniProt GlyGen
494		25813380	G57321FI	GlyGen
496		25813380	G57321FI	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
HDL remodeling	Homo sapiens

Disease

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:3393	coronary artery disease	Alliance of Genome Resources
DOID:3526	cerebral infarction	Alliance of Genome Resources
DOID:1287	cardiovascular system disease	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements