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Solute carrier organic anion transporter family member 1B1

Summary

UniProt ID: Q9Y6L6
Gene Symbol: LST1 OATP1B1 OATP2 OATPC SLC21A6 SLCO1B1
Gene ID: 10599
Organism: Homo sapiens (human)

External Links

GlyGen: Q9Y6L6
PubChem: Q9Y6L6
The Human Metabolome Database: HMDBP00454
Re-Glyco: Q9Y6L6

Annotation

Keyword: 3D-structure Cell membrane Disulfide bond Glycoprotein Ion transport Lipid transport Phosphoprotein Proteomics identification Reference proteome Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
xenobiotic metabolic process	TAS	Reactome
organic anion transport
bile acid and bile salt transport	TAS	Reactome
bile acid and bile salt transport	IBA	GO_REF
heme catabolic process	TAS	Reactome

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

xenobiotic metabolic process

catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

heme metabolic process [inference]

heme catabolic process

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

pigment metabolic process [inference]

heme metabolic process [inference]

heme catabolic process

pigment catabolic process [inference]

heme catabolic process

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

lipid transport [inference]

bile acid and bile salt transport

organic anion transport

sodium-independent organic anion transport

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

bile acid and bile salt transport

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

bile acid and bile salt transport

organic hydroxy compound transport [inference]

bile acid and bile salt transport

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GO Term	Evidence Code	Reference
plasma membrane	TAS	PMID Reactome Reactome Reactome Reactome Reactome Reactome
plasma membrane	IDA	GO_REF
basal plasma membrane	IDA	PMID
basal plasma membrane	IEA	GO_REF
membrane	TAS	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

plasma membrane region [inference]

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
obsolete organic anion transmembrane transporter activity
bile acid transmembrane transporter activity	TAS	Reactome Reactome
bile acid transmembrane transporter activity	IBA	GO_REF
prostaglandin transmembrane transporter activity	IDA	PMID
obsolete sodium-independent organic anion transmembrane transporter activity

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

thyroid hormone transmembrane transporter activity

carboxylic acid transmembrane transporter activity [inference]

monocarboxylic acid transmembrane transporter activity [inference]

bile acid transmembrane transporter activity

lipid transmembrane transporter activity [inference]

bile acid transmembrane transporter activity

icosanoid transmembrane transporter activity [inference]

prostaglandin transmembrane transporter activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGYYRYSKETNINSSENSTSTLSTCLINQILSLNRASPEIVGKGCLKESGSYMWIYVFMGNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQTPNKPQKERKASLSLHVLETNDEKDQTANLTNQGKNITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYFFILCENKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCKSSSGNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTNNCGTRGSCRTYNSTSFSRVYLGLSSMLRVSSLVLYIILIYAMKKKYQEKDINASENGSVMDEANLESLNKNKHFVPSAGADSETHC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 8** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
8		37074911	G34989PA G00912UN G90659AW	GlyGen
130	N-linked (GlcNAc...) asparagine			UniProt GlyGen
134	N-linked (GlcNAc...) asparagine	23285087		UniProt GlyGen
250				GlyGen
432	N-linked (GlcNAc...) asparagine			UniProt GlyGen
503	N-linked (GlcNAc...) asparagine	23285087		UniProt GlyGen
516	N-linked (GlcNAc...) asparagine	23285087		UniProt GlyGen
617	N-linked (GlcNAc...) asparagine			UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
Atorvastatin ADME	Homo sapiens
Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)	Homo sapiens
Heme degradation	Homo sapiens
Recycling of bile acids and salts	Homo sapiens
Transport of organic anions	Homo sapiens

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:2741	bilirubin metabolic disorder	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Acknowledgements