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Tolloid-like protein 2

Summary

UniProt ID: Q9Y6L7
Gene Symbol: KIAA0932 TLL2
Gene ID: 7093
Organism: Homo sapiens (human)

External Links

GlyConnect

Tolloid-like protein 2

GlyGen

Q9Y6L7

PubChem

Q9Y6L7

Re-Glyco

Q9Y6L7

Annotation

Keyword: Calcium Cleavage on pair of basic residues Developmental protein Differentiation Direct protein sequencing Disulfide bond EGF-like domain Glycoprotein Metal-binding Metalloprotease Methylation Proteomics identification Reference proteome Repeat Secreted Signal Zinc Zymogen

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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2

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GO Term	Evidence Code	Reference
dorsal/ventral pattern formation	IBA	GO_REF
protein processing	IBA	GO_REF
cell differentiation
collagen fibril organization	TAS	Reactome
collagen fibril organization	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein maturation [inference]

protein processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein maturation [inference]

protein processing

cellular developmental process [inference]

cell differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

dorsal/ventral pattern formation

developmental process [inference]

cellular developmental process [inference]

cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of growth [inference]

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of skeletal muscle tissue growth

regulation of developmental growth [inference]

regulation of skeletal muscle tissue growth [inference]

negative regulation of skeletal muscle tissue growth

negative regulation of developmental growth [inference]

negative regulation of skeletal muscle tissue growth

negative regulation of biological process [inference]

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of skeletal muscle tissue growth

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of skeletal muscle tissue growth

regulation of developmental process [inference]

regulation of developmental growth [inference]

regulation of skeletal muscle tissue growth [inference]

negative regulation of skeletal muscle tissue growth

negative regulation of developmental growth [inference]

negative regulation of skeletal muscle tissue growth

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of skeletal muscle tissue growth

Displaying **all 3** entries
GO Term	Evidence Code	Reference
extracellular region	TAS	Reactome Reactome
extracellular region	IEA	GO_REF
obsolete extracellular space

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
metalloendopeptidase activity	IBA	GO_REF
metalloendopeptidase activity	IEA	GO_REF
serine-type endopeptidase activity	TAS	Reactome
serine-type endopeptidase activity	IEA	GO_REF
calcium ion binding	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MPRATALGALVSLLLLLPLPRGAGGLGERPDATADYSELDGEEGTEQQLEHYHDPCKAAVFWGDIALDEDDLKLFHIDKARDWTKQTVGATGHSTGGLEEQASESSPDTTAMDTGTKEAGKDGRENTTLLHSPGTLHAAAKTFSPRVRRATTSRTERIWPGGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDEESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRQDDNGVRPTIGQRVRLSQGDIAQARKLYKCPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARYTSTKFQDALHMKK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 10** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
126			G80920RR	GlyGen
171	N-linked (GlcNAc...) asparagine	29741879	G82830MN	UniProt GlyGen GlyConnect
319		23584533	G57321FI	GlyGen
327		23584533	G57321FI	GlyGen
361	N-linked (GlcNAc...) asparagine			UniProt GlyGen
384				GlyGen
392	N-linked (GlcNAc...) asparagine			UniProt GlyGen
529				GlyGen
628	N-linked (GlcNAc...) asparagine			UniProt GlyGen
805	N-linked (GlcNAc...) asparagine			UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Anchoring fibril formation	Homo sapiens
Collagen biosynthesis and modifying enzymes	Homo sapiens
Crosslinking of collagen fibrils	Homo sapiens
Degradation of the extracellular matrix	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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External Links

Annotation

International Collaboration

Acknowledgements