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Xylosyl- and glucuronyltransferase LARGE1

Summary

UniProt ID: Q9Z1M7
Gene Symbol: Kiaa0609 Large Large1
Gene ID: 16795
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0007843
PubChem: Q9Z1M7
Re-Glyco: Q9Z1M7

Annotation

Keyword: Coiled coil Glycoprotein Glycosyltransferase Golgi apparatus Manganese Metal-binding Multifunctional enzyme Reference proteome Signal-anchor Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 95 in total

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GO Term	Evidence Code	Reference
blood vessel development	IMP	PMID
behavioral fear response	IMP	PMID
neuron migration	IMP	PMID PMID PMID
protein O-linked glycosylation	IMP	PMID
protein targeting to membrane	IDA	PMID

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

neuromuscular synaptic transmission

signal transduction [inference]

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway

ensheathment of neurons [inference]

axon ensheathment [inference]

myelination

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

protein O-linked glycosylation

protein O-linked glycosylation via mannose

gene expression

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

protein O-linked glycosylation

protein O-linked glycosylation via mannose

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

protein O-linked glycosylation

protein O-linked glycosylation via mannose

gene expression

protein metabolic process [inference]

glycoprotein metabolic process

glycoprotein biosynthetic process

protein O-linked glycosylation

protein O-linked glycosylation via mannose

protein modification process [inference]

post-translational protein modification

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process

glycoprotein biosynthetic process

protein O-linked glycosylation

protein O-linked glycosylation via mannose

protein modification process [inference]

post-translational protein modification

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process

glycoprotein biosynthetic process

protein O-linked glycosylation

protein O-linked glycosylation via mannose

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

protein O-linked glycosylation

protein O-linked glycosylation via mannose

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation

mononuclear cell differentiation [inference]

macrophage differentiation

glial cell differentiation [inference]

astrocyte differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation

skeletal muscle cell differentiation [inference]

skeletal muscle fiber differentiation

muscle cell differentiation [inference]

striated muscle cell differentiation [inference]

myotube differentiation

skeletal muscle fiber differentiation

cell development [inference]

muscle cell development [inference]

striated muscle cell development

myotube cell development [inference]

skeletal muscle fiber development

cardiac muscle cell development

cardiac cell development [inference]

cardiac muscle cell development

cell motility [inference]

cell migration [inference]

neuron migration

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

localization within membrane [inference]

protein localization to membrane

protein localization to plasma membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane

localization of cell

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly [inference]

synaptic assembly at neuromuscular junction

protein-containing complex assembly

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly [inference]

synaptic assembly at neuromuscular junction

synapse organization

synapse assembly [inference]

synaptic assembly at neuromuscular junction

neuromuscular junction development

synaptic assembly at neuromuscular junction

extracellular structure organization [inference]

extracellular matrix organization [inference]

basement membrane organization

protein-containing complex organization [inference]

protein-containing complex assembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

basement membrane organization

membrane organization [inference]

plasma membrane organization

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

striated muscle contraction

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

cognition [inference]

learning or memory [inference]

memory

neuromuscular process

neuromuscular process controlling posture

behavior [inference]

behavioral defense response [inference]

behavioral fear response

learning or memory [inference]

memory

locomotory behavior [inference]

walking behavior

determination of adult lifespan

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

multicellular organism growth

developmental process [inference]

anatomical structure morphogenesis [inference]

post-embryonic animal morphogenesis [inference]

post-embryonic appendage morphogenesis [inference]

post-embryonic limb morphogenesis [inference]

post-embryonic hindlimb morphogenesis

appendage morphogenesis [inference]

limb morphogenesis [inference]

post-embryonic limb morphogenesis [inference]

post-embryonic hindlimb morphogenesis

hindlimb morphogenesis [inference]

post-embryonic hindlimb morphogenesis

post-embryonic appendage morphogenesis [inference]

post-embryonic limb morphogenesis [inference]

post-embryonic hindlimb morphogenesis

anatomical structure formation involved in morphogenesis [inference]

retina layer formation

anatomical structure development [inference]

blood vessel development

tissue development [inference]

muscle tissue development [inference]

striated muscle tissue development [inference]

cardiac muscle tissue development

connective tissue development

regeneration [inference]

tissue regeneration [inference]

skeletal muscle tissue regeneration

cell development [inference]

muscle cell development [inference]

striated muscle cell development

myotube cell development [inference]

skeletal muscle fiber development

cardiac muscle cell development

cardiac cell development [inference]

cardiac muscle cell development

animal organ development [inference]

muscle organ development

skeletal muscle organ development

bone development

system development [inference]

vasculature development [inference]

retina vasculature development in camera-type eye

appendage development [inference]

limb development

neural nucleus development [inference]

trigeminal sensory nucleus development [inference]

principal sensory nucleus of trigeminal nerve development

retina development in camera-type eye

muscle structure development [inference]

muscle organ development

skeletal muscle organ development

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation

mononuclear cell differentiation [inference]

macrophage differentiation

glial cell differentiation [inference]

astrocyte differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation

skeletal muscle cell differentiation [inference]

skeletal muscle fiber differentiation

muscle cell differentiation [inference]

striated muscle cell differentiation [inference]

myotube differentiation

skeletal muscle fiber differentiation

cell development [inference]

muscle cell development [inference]

striated muscle cell development

myotube cell development [inference]

skeletal muscle fiber development

cardiac muscle cell development

cardiac cell development [inference]

cardiac muscle cell development

growth [inference]

developmental growth [inference]

multicellular organism growth

tissue regeneration [inference]

skeletal muscle tissue regeneration

synaptic assembly at neuromuscular junction

homeostatic process [inference]

cellular homeostasis [inference]

muscle cell cellular homeostasis

response to stimulus [inference]

response to stress [inference]

defense response [inference]

behavioral defense response [inference]

behavioral fear response

inflammatory response [inference]

neuroinflammatory response [inference]

reactive gliosis

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

response to external stimulus [inference]

response to mechanical stimulus

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus

response to mechanical stimulus

localization [inference]

macromolecule localization [inference]

intracellular protein localization

protein transport [inference]

intracellular protein transport

protein localization to membrane

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

protein transport [inference]

intracellular protein transport

fluid transport [inference]

water transport

intracellular transport [inference]

intracellular protein transport

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

protein transport [inference]

intracellular protein transport

establishment of protein localization to membrane [inference]

protein targeting to membrane

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

localization within membrane [inference]

protein localization to membrane

protein localization to plasma membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane

localization of cell

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

neuromuscular synaptic transmission

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of cellular process [inference]

signal transduction [inference]

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of biological quality [inference]

regulation of synaptic plasticity

long-term synaptic potentiation

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	Reference
Golgi membrane	ISS	GO_REF
Golgi membrane	ISO	GO_REF
Golgi membrane	IDA	PMID
Golgi membrane	IEA	GO_REF
Golgi apparatus	ISS	GO_REF

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

cell junction [inference]

synapse [inference]

neuromuscular junction

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	Reference
glucuronosyltransferase activity	ISO	GO_REF
glucuronosyltransferase activity	IDA	PMID PMID PMID PMID
glucuronosyltransferase activity	IBA	GO_REF
glucuronosyltransferase activity	IEA	GO_REF GO_REF
glycosyltransferase activity	NAS	PMID

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity

UDP-glycosyltransferase activity [inference]

glucuronosyltransferase activity

hexosyltransferase activity

glucuronosyltransferase activity

pentosyltransferase activity [inference]

xylosyltransferase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

manganese ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MLGICRGRRKFLAASLTLLCIPAITWIYLFAGSFEDGKPVSLSPLESQAHSPRYTASSQRERESLEVRVREVEEENRALRRQLSLAQGQSPAHHRGNHSKTYSMEEGTGDSENLRAGIVAGNSSECGQQPAVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSETDVNNENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEFEPSADNTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMSRQNVGYHIVYKEGQFYPVNLLRNVAMKHISTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYQVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDAQEYEFTVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	Source
97	N-linked (GlcNAc...) asparagine	GlycoProtDB UniProt
122	N-linked (GlcNAc...) asparagine	GlycoProtDB UniProt
148	N-linked (GlcNAc...) asparagine	UniProt
272	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Matriglycan biosynthesis on DAG1	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements